STRINGSTRING
PPM1F PPM1F PYCARD PYCARD CAV1 CAV1 POT1 POT1 PTPRJ PTPRJ CBLB CBLB CD300A CD300A TEN1 TEN1 LATS2 LATS2 LOC102746922 LOC102746922 CDK5RAP1 CDK5RAP1 PKIA PKIA SFRP2 SFRP2 FABP4 FABP4 MSTN MSTN LOC102740025 LOC102740025 KAT2B KAT2B SH3BP5L SH3BP5L LOC102749335 LOC102749335 PLK1 PLK1 LAX1 LAX1 PARP3 PARP3 CDKN2C CDKN2C PRKAR2B PRKAR2B PTPRB PTPRB DVL1 DVL1 PTEN PTEN LRP6 LRP6 CDKN1B CDKN1B PRKAR2A PRKAR2A CORO1C CORO1C RGS14 RGS14 WWTR1 WWTR1 PIK3IP1 PIK3IP1 SRC SRC DNAJC3 DNAJC3 PTPRO PTPRO HHEX HHEX HSPB1 HSPB1 LOC102739980 LOC102739980 FBXO5 FBXO5 DDR2 DDR2 ADAR ADAR GBA GBA TNFAIP3 TNFAIP3 PTPRQ PTPRQ PPM1E PPM1E HMGCR HMGCR PKIG PKIG GADD45A GADD45A LATS1 LATS1 HEXIM1 HEXIM1 BAG2 BAG2 LOC102732879 LOC102732879 SOCS4 SOCS4 LOC102726900 LOC102726900 CAV3 CAV3 SPRY3 SPRY3 LOC102751229 LOC102751229 PRKAR1B PRKAR1B ITGB1BP1 ITGB1BP1 MVP MVP PKN1 PKN1 CAMK2N1 CAMK2N1 LOC102737090 LOC102737090 SMYD3 SMYD3 TP53 TP53 SPRY4 SPRY4 TRIB1 TRIB1 CBL CBL THY1 THY1 IFNG IFNG PIP4K2C PIP4K2C LOC102736999 LOC102736999 RB1 RB1 MIDN MIDN CDKN2D CDKN2D SPRY1 SPRY1 GCKR GCKR LOC102738981 LOC102738981 LOC102733070 LOC102733070 LOC102750518 LOC102750518 LOC102736765 LOC102736765 LOC102735453 LOC102735453 CAMK2N2 CAMK2N2 LOC102736146 LOC102736146 LOC102735151 LOC102735151 LOC102748833 LOC102748833 CDKN1A CDKN1A AKT1S1 AKT1S1 NPRL2 NPRL2 LOC102738369 LOC102738369 VPS25 VPS25 HNRNPU HNRNPU DBNDD1 DBNDD1 BMP2 BMP2 AGT AGT PHPT1 PHPT1 GSK3A GSK3A LOC102726984 LOC102726984 QARS QARS NF1 NF1 SMCR8 SMCR8 LOC102744093 LOC102744093 BUB1B BUB1B LOC102740547 LOC102740547 LOC102743045 LOC102743045 ABL1 ABL1 BAG5 BAG5 UBASH3B UBASH3B CBLC CBLC LOC102739346 LOC102739346 EPHA1 EPHA1 LOC102729692 LOC102729692 SOCS5 SOCS5 GGNBP2 GGNBP2 SMPD1 SMPD1 LOC102730087 LOC102730087 PARK7 PARK7 ERRFI1 ERRFI1 CEP85 CEP85 SFRP1 SFRP1 TSG101 TSG101 LOC102729387 LOC102729387 GNB2L1 GNB2L1 CDKN2A CDKN2A CDKN2B CDKN2B DEPTOR DEPTOR PAQR3 PAQR3 LOC102741824 LOC102741824 LOC102729166 LOC102729166 LOC102737520 LOC102737520 TFAP4 TFAP4 NUP62 NUP62 USP44 USP44 PTPN2 PTPN2 LOC102749493 LOC102749493 ZFP36 ZFP36 PIP4K2B PIP4K2B INCA1 INCA1 DTX3L DTX3L PRKAG2 PRKAG2 BMP7 BMP7 PRKAR1A PRKAR1A FAM72A FAM72A INPP5K INPP5K
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPM1FProtein phosphatase 1F. (287 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
POT1Protection of telomeres protein 1-like. (516 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1218 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
CD300ACMRF35-like molecule 8. (309 aa)
TEN1CST complex subunit TEN1. (136 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
LOC102746922Mitotic checkpoint protein BUB3-like. (142 aa)
CDK5RAP1CDK5 regulatory subunit-associated protein 1 isoform X1. (583 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
SH3BP5LSH3 domain-binding protein 5-like. (385 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (432 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (417 aa)
PTPRBReceptor-type tyrosine-protein phosphatase beta. (1997 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (391 aa)
CORO1Ccoronin-1C. (303 aa)
RGS14Regulator of G-protein signaling 14. (85 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (268 aa)
SRCTyrosine-protein kinase. (536 aa)
DNAJC3dnaJ homolog subfamily C member 3. (504 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (270 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
LOC102739980F-box only protein 5-like. (228 aa)
FBXO5F-box only protein 5-like. (446 aa)
DDR2Discoidin domain-containing receptor 2-like. (367 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1145 aa)
GBAGlucosylceramidase. (536 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
PTPRQPhosphatidylinositol phosphatase PTPRQ. (2300 aa)
PPM1EProtein phosphatase 1E. (756 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (887 aa)
PKIGcAMP-dependent protein kinase inhibitor gamma. (75 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
HEXIM1Protein HEXIM1. (359 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
LOC102751229Zinc finger protein RFP-like isoform X1. (513 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (145 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
MVPMajor vault protein. (890 aa)
PKN1Serine/threonine-protein kinase N1. (796 aa)
CAMK2N1Calcium/calmodulin-dependent protein kinase II inhibitor 1. (78 aa)
LOC102737090Sortilin-related receptor-like. (446 aa)
SMYD3Histone-lysine N-methyltransferase SMYD3. (190 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
TRIB1Tribbles homolog 1. (292 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (220 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
RB1Retinoblastoma-associated protein. (846 aa)
MIDNMidnolin. (489 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D isoform X2. (166 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
GCKRLOW QUALITY PROTEIN: glucokinase (Hexokinase 4) regulator. (482 aa)
LOC102738981Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (143 aa)
LOC102733070Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (117 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102736765Interleukin-1 receptor-associated kinase 3-like. (125 aa)
LOC102735453LIM domain-containing protein ajuba-like. (345 aa)
CAMK2N2Calcium/calmodulin-dependent protein kinase II inhibitor 2. (79 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
LOC102738369Merlin-like. (110 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (176 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
DBNDD1Dysbindin domain-containing protein 1. (158 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PHPT114 kDa phosphohistidine phosphatase isoform X1. (125 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
LOC102726984Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like. (135 aa)
QARSglutamine--tRNA ligase isoform X2; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
NF1Neurofibromin-like. (1269 aa)
SMCR8smith-Magenis syndrome chromosomal region candidate gene 8 protein. (937 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (986 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
BAG5BAG family molecular chaperone regulator 5. (448 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (592 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (496 aa)
LOC102739346Dysbindin-like. (159 aa)
EPHA1Ephrin type-A receptor 1. (976 aa)
LOC102729692Ras-interacting protein 1-like. (208 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
GGNBP2Gametogenetin-binding protein 2 isoform X1. (740 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
LOC102730087Ceramide synthase 1-like. (99 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (460 aa)
CEP85Centrosomal protein of 85 kDa. (768 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (391 aa)
LOC102729387F-box only protein 7-like. (300 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (305 aa)
PAQR3Progestin and adipoQ receptor family member 3 isoform X2. (311 aa)
LOC102741824Dysbindin-like. (250 aa)
LOC102729166Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (134 aa)
LOC102737520Cytochrome c oxidase assembly protein COX11, mitochondrial-like isoform X1. (275 aa)
TFAP4Transcription factor AP-4. (337 aa)
NUP62Nuclear pore glycoprotein p62. (525 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (697 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
LOC102749493Zinc finger CCCH-type with G patch domain-containing protein-like. (194 aa)
ZFP36Tristetraprolin. (325 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
INCA1Protein INCA1. (251 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (692 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
FAM72AProtein FAM72A. (149 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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