(102 nodes) Positive regulation of cytoskeleton organization network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	LOC102729725	Cdc42 effector protein 5-like. (75 aa)
	LOC102734471	Dynactin subunit 1-like. (1117 aa)
	LOC102746252	Tyrosine-protein kinase Fes/Fps-like. (444 aa)
	PPP1R35	Protein phosphatase 1 regulatory subunit 35. (264 aa)
	NAV3	Neuron navigator 3-like. (497 aa)
	LOC102736866	Cytoplasmic dynein 1 heavy chain 1-like. (856 aa)
	LOC102737664	Gelsolin-like. (513 aa)
	LOC102738369	Merlin-like. (110 aa)
	LOC102731348	CDK5 regulatory subunit-associated protein 2-like. (233 aa)
	LOC102741867	Villin-1-like. (505 aa)
	FCHSD1	FCH and double SH3 domains protein 1. (691 aa)
	LOC102730108	Neuropilin-1-like. (465 aa)
	LOC102738856	Villin-like protein-like. (205 aa)
	SLAIN1	SLAIN motif-containing protein 1. (300 aa)
	LOC102738455	Destrin-like; Belongs to the actin-binding proteins ADF family. (165 aa)
	LOC102731633	Rho guanine nucleotide exchange factor 10-like. (410 aa)
	VIL1	Villin-1. (330 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	LOC102747142	Tyrosine-protein kinase. (395 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	EPHA1	Ephrin type-A receptor 1. (976 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	TESK1	Dual specificity testis-specific protein kinase 1. (628 aa)
	PFDN2	Prefoldin subunit 2. (154 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	BAIAP2L1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1. (478 aa)
	LOC102747320	Katanin p80 WD40 repeat-containing subunit B1-like. (245 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
	MAPK15	Mitogen-activated protein kinase. (559 aa)
	NUP62	Nuclear pore glycoprotein p62. (525 aa)
	PPM1F	Protein phosphatase 1F. (287 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	CEP120	Centrosomal protein of 120 kDa. (910 aa)
	NPHS1	Nephrin. (1242 aa)
	RICTOR	Rapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
	WASF3	wiskott-Aldrich syndrome protein family member 3-like. (328 aa)
	CLIP1	CAP-Gly domain-containing linker protein 1 isoform X1. (1438 aa)
	CENPJ	Centromere protein J. (1354 aa)
	MTSS1	Metastasis suppressor protein 1 isoform X3. (529 aa)
	PSRC1	Proline/serine-rich coiled-coil protein 1. (303 aa)
	BAG4	BAG family molecular chaperone regulator 4. (421 aa)
	SERPINF2	Alpha-2-antiplasmin; Belongs to the serpin family. (415 aa)
	VILL	Villin-like protein-like. (375 aa)
	SLAIN2	SLAIN motif-containing protein 2 isoform X1. (582 aa)
	CDC42EP1	Cdc42 effector protein 1. (374 aa)
	SYNPO2	Synaptopodin-2. (1343 aa)
	LOC102736082	Sorting nexin-9-like. (218 aa)
	CDC42EP3	Cdc42 effector protein 3. (249 aa)
	CTGF	Connective tissue growth factor. (211 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PLXNA3	plexin-A3. (1452 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (499 aa)
	CCL21	c-C motif chemokine 21. (137 aa)
	OCLN	Occludin. (271 aa)
	VASP	Vasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
	LOC102734190	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
	HSPA1L	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
	WAS	wiskott-Aldrich syndrome protein. (501 aa)
	ACTN2	Alpha-actinin-2 isoform X1. (894 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (842 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1 isoform X1. (200 aa)
	CDC42EP2	Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
	ARL2	ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	TEK	Angiopoietin-1 receptor isoform X1. (1125 aa)
	LOC102751229	Zinc finger protein RFP-like isoform X1. (513 aa)
	CTTN	Src substrate cortactin. (545 aa)
	MYOC	Myocilin. (490 aa)
	GSN	Gelsolin. (189 aa)
	CCDC88A	Girdin isoform X2. (1846 aa)
	FERMT2	Fermitin family homolog 2 isoform X1. (687 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	F2RL1	Proteinase-activated receptor 2. (415 aa)
	PPM1E	Protein phosphatase 1E. (756 aa)
	LOC102731157	ARF GTPase-activating protein GIT1-like. (191 aa)
	DLG2	Disks large homolog 2 isoform X1. (905 aa)
	CCL26	C-C motif chemokine. (94 aa)
	CCL24	c-C motif chemokine 24. (119 aa)
	LPAR1	Lysophosphatidic acid receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	PFN2	Profilin; Belongs to the profilin family. (140 aa)
	PFN3	Profilin; Belongs to the profilin family. (137 aa)
	SASS6	Spindle assembly abnormal protein 6 homolog. (657 aa)
	CFL2	Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
	SPAG5	Sperm-associated antigen 5. (1196 aa)
	SYNPO2L	Synaptopodin 2-like protein. (970 aa)
	KIAA1211	Uncharacterized protein KIAA1211 homolog. (1224 aa)
	SCIN	Adseverin. (686 aa)
	LOC102726679	Protein S100-A10-like; Belongs to the S-100 family. (97 aa)
	FCHSD2	FCH and double SH3 domains protein 2 isoform X1. (763 aa)
	PDE4DIP	Myomegalin-like isoform X2. (1116 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	ARF6	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	WASF1	wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
	STAP1	Signal-transducing adaptor protein 1. (332 aa)
	NCKAP1L	Nck-associated protein 1-like. (1134 aa)
	SWAP70	Switch-associated protein 70 isoform X1. (585 aa)
	S100A10	Protein S100-A10; Belongs to the S-100 family. (97 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	WASL	Neural Wiskott-Aldrich syndrome protein. (487 aa)
	PLK4	Serine/threonine-protein kinase PLK4 isoform X1. (970 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BAIAP2L1	A0A2U3YZ15	A0A2U3YQY5	Tyrosine-protein kinase ABL1-like.	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1.	0.538
ABL1	CDKN1B	A0A2U3YZ15	A0A2U3XNU5	Tyrosine-protein kinase ABL1-like.	Cyclin-dependent kinase inhibitor 1B.	0.508
ABL1	EPHA1	A0A2U3YZ15	A0A2U3YW48	Tyrosine-protein kinase ABL1-like.	Ephrin type-A receptor 1.	0.905
ABL1	LOC102746252	A0A2U3YZ15	A0A2U3Z6Y8	Tyrosine-protein kinase ABL1-like.	Tyrosine-protein kinase Fes/Fps-like.	0.807
ABL1	LOC102750030	A0A2U3YZ15	A0A2U3Z8N4	Tyrosine-protein kinase ABL1-like.	Protein-tyrosine kinase 2-beta-like.	0.692
ABL1	MAPK15	A0A2U3YZ15	A0A2U3YP18	Tyrosine-protein kinase ABL1-like.	Mitogen-activated protein kinase.	0.482
ABL1	NCK1	A0A2U3YZ15	A0A2U3X949	Tyrosine-protein kinase ABL1-like.	Cytoplasmic protein.	0.605
ABL1	NCK2	A0A2U3YZ15	A0A2U3YX25	Tyrosine-protein kinase ABL1-like.	Cytoplasmic protein.	0.423
ABL1	NCKAP1L	A0A2U3YZ15	A0A2U3XBB9	Tyrosine-protein kinase ABL1-like.	Nck-associated protein 1-like.	0.748
ABL1	VASP	A0A2U3YZ15	A0A2U3Y4N8	Tyrosine-protein kinase ABL1-like.	Vasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.	0.805
ABL1	WASF1	A0A2U3YZ15	A0A2U3XDK1	Tyrosine-protein kinase ABL1-like.	wiskott-Aldrich syndrome protein family member 1 isoform X1.	0.586
ABL1	WASF3	A0A2U3YZ15	A0A2U3YFV4	Tyrosine-protein kinase ABL1-like.	wiskott-Aldrich syndrome protein family member 3-like.	0.560
ARF6	ARL2	A0A2U3XDZ6	A0A2U3Y0C8	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family.	0.487
ARF6	CTTN	A0A2U3XDZ6	A0A2U3XZI1	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Src substrate cortactin.	0.454
ARF6	LOC102731157	A0A2U3XDZ6	A0A2U3XT20	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	ARF GTPase-activating protein GIT1-like.	0.578
ARF6	WASL	A0A2U3XDZ6	A0A2U3X8S1	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Neural Wiskott-Aldrich syndrome protein.	0.423
ARHGEF15	EPHA1	A0A2U3Y3H5	A0A2U3YW48	Rho guanine nucleotide exchange factor 15.	Ephrin type-A receptor 1.	0.556
ARL2	ARF6	A0A2U3Y0C8	A0A2U3XDZ6	ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family.	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.487
BAG4	HSPA1L	A0A2U3YCN8	A0A2U3Y468	BAG family molecular chaperone regulator 4.	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family.	0.486
BAG4	LOC102734190	A0A2U3YCN8	A0A2U3Y4I2	BAG family molecular chaperone regulator 4.	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family.	0.486