STRINGSTRING
PIDD PIDD LOC102740466 LOC102740466 SHH SHH SPRTN SPRTN LOC102736150 LOC102736150 LOC102751105 LOC102751105 PRSS48 PRSS48 NAT6 NAT6 CASP6 CASP6 TLL1 TLL1 CPE CPE LOC102730290 LOC102730290 HM13 HM13 DUOXA2 DUOXA2 MEP1A MEP1A MIPEP MIPEP ASPRV1 ASPRV1 APH1A APH1A IMMP1L IMMP1L PHEX PHEX RAP1GDS1 RAP1GDS1 TSPAN33 TSPAN33 DHH DHH APOH APOH PYCARD PYCARD NFU1 NFU1 XPNPEP3 XPNPEP3 EP300 EP300 KAT2B KAT2B NDNL2 NDNL2 SCG5 SCG5 MYRF MYRF LOC102737759 LOC102737759 DHPS DHPS NDUFAB1 NDUFAB1 CIAO1 CIAO1 NLRC4 NLRC4 PMPCB PMPCB LOC102742375 LOC102742375 CPXM1 CPXM1 LIAS LIAS MYRFL MYRFL LOC102725978 LOC102725978 PCSK1 PCSK1 PISD PISD MMP16 MMP16 SRCRB4D SRCRB4D LOC102734269 LOC102734269 LIPT1 LIPT1 YIPF5 YIPF5 SEC11C SEC11C PAWR PAWR TSPAN14 TSPAN14 NAA35 NAA35 TMPRSS12 TMPRSS12 LMF2 LMF2 TLL2 TLL2 LOC102750923 LOC102750923 APH1B APH1B FADD FADD P2RX7 P2RX7 CNTN2 CNTN2 LOC102749275 LOC102749275 IL1R2 IL1R2 ZMPSTE24 ZMPSTE24 LOC102732685 LOC102732685 NAA20 NAA20 SPPL3 SPPL3 C1RL C1RL C1R C1R NAA15 NAA15 BAK1 BAK1 ECE2 ECE2 PTCH1 PTCH1 PCSK1N PCSK1N LOC102737090 LOC102737090 CIDEB CIDEB LOC102747776 LOC102747776 LOC102727326 LOC102727326 STOML2 STOML2 NAA50 NAA50 SEC11A SEC11A NAA10 NAA10 TBC1D10A TBC1D10A SMIM13 SMIM13 KLK13 KLK13 ADAMTS3 ADAMTS3 CPN1 CPN1 NAA16 NAA16 TMEM208 TMEM208 FAM96B FAM96B LOC102735800 LOC102735800 NLRP6 NLRP6 KLKB1 KLKB1 METAP1 METAP1 SDE2 SDE2 HP HP PSEN2 PSEN2 CBWD1 CBWD1 F9 F9 PSENEN PSENEN LONP2 LONP2 NAA11 NAA11 CISD3 CISD3 YAE1D1 YAE1D1 LOC102735209 LOC102735209 LOC102736707 LOC102736707 LOC102730370 LOC102730370 PRSS12 PRSS12 SPCS1 SPCS1 PLAT PLAT PCSK2 PCSK2 GLG1 GLG1 CASP7 CASP7 SERPINH1 SERPINH1 SPG7 SPG7 ISCA2 ISCA2 LOC102725545 LOC102725545 TASP1 TASP1 CBWD3 CBWD3 LOC102749794 LOC102749794 PCSK4 PCSK4 CTSH CTSH LOC102732625 LOC102732625 MMEL1 MMEL1 SPON1 SPON1 SPCS2 SPCS2 MMP14 MMP14 CREBBP CREBBP LOC102747329 LOC102747329 LOC102726841 LOC102726841 HFE2 HFE2 LOC102742241 LOC102742241 RCE1 RCE1 CASP2 CASP2 SNAPIN SNAPIN GCSH GCSH COMP COMP LIPT2 LIPT2 CHCHD4 CHCHD4 LOC102734830 LOC102734830 CASP9 CASP9 DDI2 DDI2 LOC102733731 LOC102733731 CASP8 CASP8 OGT OGT TYSND1 TYSND1 PRSS37 PRSS37 LOC102730319 LOC102730319 ECEL1 ECEL1 LOC102746352 LOC102746352 AFG3L2 AFG3L2 LOC102740269 LOC102740269 NCSTN NCSTN LOC102745544 LOC102745544 LOC102739675 LOC102739675 LOC102751009 LOC102751009 MMS19 MMS19 PITRM1 PITRM1 LOC102743801 LOC102743801 FURIN FURIN REN REN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIDDP53-induced protein with a death domain. (916 aa)
LOC102740466Polypeptide N-acetylgalactosaminyltransferase 2-like. (258 aa)
SHHSonic hedgehog protein-like. (286 aa)
SPRTNsprT-like domain-containing protein Spartan. (484 aa)
LOC102736150Paraplegin-like. (200 aa)
LOC102751105Kallikrein-1-like; Belongs to the peptidase S1 family. (261 aa)
PRSS48LOW QUALITY PROTEIN: protease, serine, 48; Belongs to the peptidase S1 family. (528 aa)
NAT6LOW QUALITY PROTEIN: N-acetyltransferase 6 (GCN5-related). (297 aa)
CASP6Caspase-6 isoform X1; Belongs to the peptidase C14A family. (293 aa)
TLL1Metalloendopeptidase. (935 aa)
CPECarboxypeptidase E. (440 aa)
LOC102730290Macrophage scavenger receptor types I and II-like. (454 aa)
HM13Minor histocompatibility antigen H13 isoform X1. (427 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
MEP1AMeprin A subunit. (720 aa)
MIPEPMitochondrial intermediate peptidase. (674 aa)
ASPRV1LOW QUALITY PROTEIN: retroviral-like aspartic protease 1. (456 aa)
APH1AGamma-secretase subunit APH-1A isoform X1. (265 aa)
IMMP1LMitochondrial inner membrane protease subunit. (166 aa)
PHEXPhosphate-regulating neutral endopeptidase. (729 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 isoform X1. (607 aa)
TSPAN33Tetraspanin. (283 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
NFU1NFU1 iron-sulfur cluster scaffold homolog, mitochondrial. (196 aa)
XPNPEP3Probable Xaa-Pro aminopeptidase 3 isoform X1. (507 aa)
EP300Histone acetyltransferase p300. (2425 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
NDNL2Melanoma-associated antigen G1. (284 aa)
SCG5Neuroendocrine protein 7B2. (212 aa)
MYRFMyelin regulatory factor. (604 aa)
LOC102737759Cytoplasmic FMR1-interacting protein 2-like. (113 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (154 aa)
CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (339 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (908 aa)
PMPCBMitochondrial-processing peptidase subunit beta; Belongs to the peptidase M16 family. (487 aa)
LOC102742375MIP18 family protein FAM96A-like isoform X1. (160 aa)
CPXM1Probable carboxypeptidase X1 isoform X1. (736 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
MYRFLMyelin regulatory factor-like protein. (909 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
PCSK1Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (399 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
MMP16Matrix metalloproteinase-16. (613 aa)
SRCRB4DScavenger receptor cysteine-rich domain-containing group B protein. (522 aa)
LOC102734269bolA-like protein 2-like; Belongs to the BolA/IbaG family. (86 aa)
LIPT1Lipoyltransferase 1, mitochondrial. (373 aa)
YIPF5Protein YIPF. (164 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (154 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
TSPAN14Tetraspanin-14; Belongs to the tetraspanin (TM4SF) family. (147 aa)
NAA35N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1. (725 aa)
TMPRSS12Transmembrane protease serine 12; Belongs to the peptidase S1 family. (395 aa)
LMF2Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (697 aa)
TLL2Metalloendopeptidase. (1182 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
CNTN2Contactin-2. (903 aa)
LOC102749275Presenilins-associated rhomboid-like protein, mitochondrial-like. (159 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
LOC102732685Glutaredoxin-3-like; Belongs to the universal ribosomal protein uL11 family. (355 aa)
NAA20N-alpha-acetyltransferase 20 isoform X2. (178 aa)
SPPL3Signal peptide peptidase-like 3. (384 aa)
C1RLComplement C1r subcomponent-like protein; Belongs to the peptidase S1 family. (490 aa)
C1RComplement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (705 aa)
NAA15N-alpha-acetyltransferase 15, NatA auxiliary subunit. (866 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
ECE2Endothelin-converting enzyme 2-like isoform X2. (765 aa)
PTCH1Protein patched homolog 1. (1301 aa)
PCSK1NproSAAS. (143 aa)
LOC102737090Sortilin-related receptor-like. (446 aa)
CIDEBCell death activator CIDE-B. (221 aa)
LOC102747776Deoxyhypusine hydroxylase-like. (224 aa)
LOC102727326Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (334 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
NAA50N-alpha-acetyltransferase 50 isoform X1. (169 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
NAA10N-alpha-acetyltransferase 10 isoform X1. (235 aa)
TBC1D10ATBC1 domain family member 10A. (376 aa)
SMIM13Small integral membrane protein 13. (87 aa)
KLK13Kallikrein-13; Belongs to the peptidase S1 family. (278 aa)
ADAMTS3A disintegrin and metalloproteinase with thrombospondin motifs 3. (1202 aa)
CPN1Carboxypeptidase N catalytic chain. (441 aa)
NAA16N-alpha-acetyltransferase 16, NatA auxiliary subunit. (832 aa)
TMEM208Transmembrane protein 208. (173 aa)
FAM96BMitotic spindle-associated MMXD complex subunit MIP18. (164 aa)
LOC102735800Methionine aminopeptidase 2-like. (86 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (893 aa)
KLKB1Plasma kallikrein; Belongs to the peptidase S1 family. (634 aa)
METAP1Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (386 aa)
SDE2Protein SDE2 homolog. (452 aa)
HPHaptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (347 aa)
PSEN2Presenilin-2. (115 aa)
CBWD1COBW domain-containing protein 1. (113 aa)
F9Coagulation factor IX isoform X1. (459 aa)
PSENENGamma-secretase subunit PEN-2 isoform X1. (101 aa)
LONP2Lon protease homolog 2, peroxisomal. (660 aa)
NAA11N-alpha-acetyltransferase 11. (229 aa)
CISD3CDGSH iron-sulfur domain-containing protein 3, mitochondrial. (130 aa)
YAE1D1Yae1 domain-containing protein 1. (226 aa)
LOC102735209Delta(24)-sterol reductase-like. (195 aa)
LOC102736707Delta(24)-sterol reductase-like. (136 aa)
LOC102730370Carboxypeptidase M-like. (395 aa)
PRSS12Neurotrypsin; Belongs to the peptidase S1 family. (875 aa)
SPCS1Signal peptidase complex subunit 1. (162 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
PCSK2Neuroendocrine convertase 2 isoform X1; Belongs to the peptidase S8 family. (638 aa)
GLG1LOW QUALITY PROTEIN: Golgi apparatus protein 1. (641 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
SERPINH1Serpin H1 isoform X3; Belongs to the serpin family. (418 aa)
SPG7Paraplegin. (607 aa)
ISCA2Iron-sulfur cluster assembly 2 homolog, mitochondrial. (154 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
TASP1Threonine aspartase 1. (301 aa)
CBWD3Putative COBW domain-containing protein 7. (174 aa)
LOC102749794Glutaredoxin-3-like. (288 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (752 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
LOC102732625Metalloendopeptidase OMA1, mitochondrial-like. (525 aa)
MMEL1Membrane metallo-endopeptidase-like 1. (780 aa)
SPON1Spondin-1. (552 aa)
SPCS2Signal peptidase complex subunit 2. (123 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
CREBBPCREB-binding protein-like. (1411 aa)
LOC102747329dnaJ homolog subfamily B member 11-like isoform X1. (358 aa)
LOC102726841A disintegrin and metalloproteinase with thrombospondin motifs 2-like. (348 aa)
HFE2Hemojuvelin-like isoform X1. (428 aa)
LOC102742241Proprotein convertase subtilisin/kexin type 7-like. (269 aa)
RCE1CAAX prenyl protease 2-like isoform X1. (329 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (312 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
GCSHGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
COMPCartilage oligomeric matrix protein. (728 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
CHCHD4Mitochondrial intermembrane space import and assembly protein 40. (141 aa)
LOC102734830Endothelin-converting enzyme 1-like. (211 aa)
CASP9Caspase-9. (171 aa)
DDI2Regulatory solute carrier protein family 1 member 1-like isoform X2. (399 aa)
LOC102733731Atrial natriuretic peptide-converting enzyme-like. (579 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
TYSND1Peroxisomal leader peptide-processing protease. (356 aa)
PRSS37Probable inactive serine protease 37. (235 aa)
LOC102730319Melanoma-associated antigen F1-like. (323 aa)
ECEL1Endothelin-converting enzyme-like 1. (775 aa)
LOC102746352Lon protease homolog 2, peroxisomal-like; Belongs to the peptidase S16 family. (206 aa)
AFG3L2AFG3-like protein 2. (806 aa)
LOC102740269Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (179 aa)
NCSTNNicastrin. (602 aa)
LOC102745544Glutaredoxin-related protein 5, mitochondrial-like. (157 aa)
LOC102739675Threonine aspartase 1-like. (100 aa)
LOC102751009Neuroendocrine convertase 1-like. (354 aa)
MMS19MMS19 nucleotide excision repair protein homolog. (665 aa)
PITRM1Presequence protease, mitochondrial-like. (428 aa)
LOC102743801Delta(24)-sterol reductase-like. (269 aa)
FURINFurin; Belongs to the peptidase S8 family. (693 aa)
RENRenin isoform X1; Belongs to the peptidase A1 family. (411 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (16%) [HD]