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TRPC3 TRPC3 LOC102745857 LOC102745857 LOC102732559 LOC102732559 LOC102736146 LOC102736146 LOC102744509 LOC102744509 LOC102748833 LOC102748833 RAB44 RAB44 LOC102746964 LOC102746964 CAPN9 CAPN9 TMEM38A TMEM38A WFS1 WFS1 TRPC6 TRPC6 CXCR3 CXCR3 GPER1 GPER1 ORAI1 ORAI1 LOC102745728 LOC102745728 ABL1 ABL1 DRD3 DRD3 SLC30A1 SLC30A1 HOMER3 HOMER3 LOC102735431 LOC102735431 UBASH3B UBASH3B LOC102729293 LOC102729293 STAC STAC KIAA1199 KIAA1199 DHRS7C DHRS7C PDGFB PDGFB STIM1 STIM1 TMEM66 TMEM66 SPHK2 SPHK2 CALM3 CALM3 FKBP1B FKBP1B LOC102735415 LOC102735415 PRNP PRNP CXCL11 CXCL11 CXCL10 CXCL10 CXCL9 CXCL9 TMEM110 TMEM110 JSRP1 JSRP1 UCN UCN CABP2 CABP2 CABP4 CABP4 CASQ1 CASQ1 CASR CASR CACNB1 CACNB1 FFAR1 FFAR1 PSEN2 PSEN2 EFCAB4A EFCAB4A INPP5K INPP5K PLN PLN PML PML LOC102750030 LOC102750030 VMP1 VMP1 STAC3 STAC3 TSPAN31 TSPAN31 ATP2C2 ATP2C2 THY1 THY1 SLC9A1 SLC9A1 CABP5 CABP5 LOC102746494 LOC102746494 ATG5 ATG5 JPH4 JPH4 HSPA2 HSPA2 LOC102744643 LOC102744643 BAK1 BAK1 CD4 CD4 R3HDM1 R3HDM1 CABP1 CABP1 LOC102745156 LOC102745156 CACNG6 CACNG6 PPAPDC1A PPAPDC1A P2RX4 P2RX4 LOC102751229 LOC102751229 P2RX7 P2RX7 LOC102745974 LOC102745974 CAV3 CAV3 LGALS3 LGALS3 RAMP3 RAMP3 CACNB2 CACNB2 PDE4B PDE4B TSPAN13 TSPAN13 F2R F2R SESTD1 SESTD1 PAWR PAWR LOC102748960 LOC102748960 CD19 CD19 CORO1A CORO1A GNB5 GNB5 TMEM38B TMEM38B DRD1 DRD1 TMC2 TMC2 BEST3 BEST3 LOC102738071 LOC102738071 RRAD RRAD HOMER1 HOMER1 TRPC1 TRPC1 LOC102736535 LOC102736535 WNK3 WNK3 GEM GEM SRI SRI CACNG1 CACNG1 STIM2 STIM2 CHD7 CHD7 CACNB3 CACNB3 CAV1 CAV1 PPP3R2 PPP3R2 REM1 REM1 CACNA2D1 CACNA2D1 PKD2 PKD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPC3Short transient receptor potential channel 3-like. (592 aa)
LOC102745857Phosphodiesterase. (503 aa)
LOC102732559Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
RAB44Ras-related protein Rab-44. (795 aa)
LOC102746964Sodium/potassium/calcium exchanger 6, mitochondrial-like. (200 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (492 aa)
TMEM38ATrimeric intracellular cation channel type A. (252 aa)
WFS1Wolframin-like. (882 aa)
TRPC6Short transient receptor potential channel 6-like isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
CXCR3c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102745728Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like. (202 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SLC30A1Zinc transporter 1. (505 aa)
HOMER3Homer protein homolog 3 isoform X1. (359 aa)
LOC102735431C-C motif chemokine. (93 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (592 aa)
LOC102729293Transmembrane protein 110-like. (118 aa)
STACSH3 and cysteine-rich domain-containing protein. (353 aa)
KIAA1199Protein KIAA1199 homolog. (1361 aa)
DHRS7CDehydrogenase/reductase SDR family member 7C isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
STIM1Stromal interaction molecule 1. (215 aa)
TMEM66Store-operated calcium entry-associated regulatory factor. (334 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
CXCL11c-X-C motif chemokine 11. (100 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL9C-X-C motif chemokine. (126 aa)
TMEM110Transmembrane protein 110. (211 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (338 aa)
UCNUrocortin. (126 aa)
CABP2Calcium-binding protein 2. (234 aa)
CABP4Calcium-binding protein 4. (278 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (393 aa)
CASRExtracellular calcium-sensing receptor. (1074 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (643 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
PSEN2Presenilin-2. (115 aa)
EFCAB4AEF-hand calcium-binding domain-containing protein 4A. (398 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PMLProtein PML. (880 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
VMP1Vacuole membrane protein 1. (377 aa)
STAC3SH3 and cysteine-rich domain-containing protein 3 isoform X1. (364 aa)
TSPAN31Tetraspanin-31; Belongs to the tetraspanin (TM4SF) family. (210 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
CABP5Calcium-binding protein 5. (173 aa)
LOC102746494Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (226 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
LOC102744643Short transient receptor potential channel 3-like. (453 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
R3HDM1R3H domain-containing protein 1 isoform X1. (1100 aa)
CABP1Calcium-binding protein 1. (199 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
PPAPDC1APhosphatidate phosphatase PPAPDC1A isoform X2. (82 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
LOC102751229Zinc finger protein RFP-like isoform X1. (513 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
LOC102745974Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (239 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LGALS3Galectin. (285 aa)
RAMP3Receptor activity-modifying protein 3. (116 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (613 aa)
PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4B. (284 aa)
TSPAN13Tetraspanin-13; Belongs to the tetraspanin (TM4SF) family. (204 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SESTD1SEC14 domain and spectrin repeat-containing protein 1 isoform X1. (696 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
LOC102748960Cytochrome b-245 light chain-like. (196 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (345 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
TMC2Transmembrane channel-like protein 2. (414 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (679 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
HOMER1Homer protein homolog 1 isoform X1. (354 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
LOC102736535Protein 4.1-like isoform X1. (248 aa)
WNK3Serine/threonine-protein kinase WNK3 isoform X2. (1747 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
SRISorcin. (198 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
STIM2Stromal interaction molecule 2-like. (794 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2429 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1091 aa)
PKD2Polycystin-2. (935 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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