(28 nodes) Cardiac muscle cell development network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRF	Serum response factor. (508 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LOC102743063	Delta-sarcoglycan-like. (113 aa)
	LRRC10	Leucine-rich repeat-containing protein 10. (279 aa)
	SGCD	Delta-sarcoglycan. (122 aa)
	LRRC10B	Leucine-rich repeat-containing protein 10B. (279 aa)
	NKX2-6	Homeobox protein Nkx-2.6. (302 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (487 aa)
	TCAP	Telethonin isoform X2. (167 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	LOC102749615	Four and a half LIM domains protein 2-like. (110 aa)
	NEBL	LIM zinc-binding domain-containing Nebulette isoform X1. (1013 aa)
	LOC102742062	T-box transcription factor TBX5-like. (308 aa)
	MYLK3	Myosin light chain kinase 3. (99 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	LOC102744509	Autophagy protein 5-like. (78 aa)
	LMNA	prelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
	ASB2	Ankyrin repeat and SOCS box protein 2. (630 aa)
	NRAP	Nebulin-related-anchoring protein isoform X1. (1728 aa)
	CXADR	Coxsackievirus and adenovirus receptor homolog isoform X1. (365 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	MAML1	Mastermind-like protein 1. (948 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	TBX3	T-box transcription factor TBX3. (675 aa)
	ADPRHL1	[Protein ADP-ribosylarginine] hydrolase-like protein 1. (272 aa)
	ACTN2	Alpha-actinin-2 isoform X1. (894 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	LOC102742062	A0A2U3Y3N1	A0A2U3Z3X1	Alpha-actinin-2 isoform X1.	T-box transcription factor TBX5-like.	0.502
ACTN2	MYLK3	A0A2U3Y3N1	A0A2U3Z429	Alpha-actinin-2 isoform X1.	Myosin light chain kinase 3.	0.564
ACTN2	NEBL	A0A2U3Y3N1	A0A2U3YGV1	Alpha-actinin-2 isoform X1.	LIM zinc-binding domain-containing Nebulette isoform X1.	0.530
ACTN2	NRAP	A0A2U3Y3N1	A0A2U3YLD8	Alpha-actinin-2 isoform X1.	Nebulin-related-anchoring protein isoform X1.	0.527
ACTN2	TCAP	A0A2U3Y3N1	A0A2U3YTG0	Alpha-actinin-2 isoform X1.	Telethonin isoform X2.	0.633
ATG5	LOC102744509	A0A2U3Y6R5	A0A2U3Z6M9	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy protein 5-like.	0.900
ATG5	MTOR	A0A2U3Y6R5	A0A2U3XVT2	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.504
CAV3	SGCD	A0A2U3XYT3	A0A2U3XGT9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Delta-sarcoglycan.	0.441
LMNA	SGCD	A0A2U3Z6T9	A0A2U3XGT9	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Delta-sarcoglycan.	0.545
LMNA	TCAP	A0A2U3Z6T9	A0A2U3YTG0	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Telethonin isoform X2.	0.457
LMNA	ZMPSTE24	A0A2U3Z6T9	A0A2U3Y1L9	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.611
LOC102742062	ACTN2	A0A2U3Z3X1	A0A2U3Y3N1	T-box transcription factor TBX5-like.	Alpha-actinin-2 isoform X1.	0.502
LOC102743063	SGCD	A0A2U3XMM4	A0A2U3XGT9	Delta-sarcoglycan-like.	Delta-sarcoglycan.	0.957
LOC102744509	ATG5	A0A2U3Z6M9	A0A2U3Y6R5	Autophagy protein 5-like.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.900
MTOR	ATG5	A0A2U3XVT2	A0A2U3Y6R5	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.504
MYLK3	ACTN2	A0A2U3Z429	A0A2U3Y3N1	Myosin light chain kinase 3.	Alpha-actinin-2 isoform X1.	0.564
NEBL	ACTN2	A0A2U3YGV1	A0A2U3Y3N1	LIM zinc-binding domain-containing Nebulette isoform X1.	Alpha-actinin-2 isoform X1.	0.530
NEBL	TCAP	A0A2U3YGV1	A0A2U3YTG0	LIM zinc-binding domain-containing Nebulette isoform X1.	Telethonin isoform X2.	0.406
NRAP	ACTN2	A0A2U3YLD8	A0A2U3Y3N1	Nebulin-related-anchoring protein isoform X1.	Alpha-actinin-2 isoform X1.	0.527
NRAP	TCAP	A0A2U3YLD8	A0A2U3YTG0	Nebulin-related-anchoring protein isoform X1.	Telethonin isoform X2.	0.462