STRINGSTRING
PDGFRA PDGFRA LEF1 LEF1 INTU INTU GDF11 GDF11 COL2A1 COL2A1 TIPARP TIPARP CHD7 CHD7 OSR2 OSR2 MEOX2 MEOX2 SNAI1 SNAI1 FOXF2 FOXF2 CSRNP1 CSRNP1 BCOR BCOR DLG2 DLG2 SMAD4 SMAD4 PYGO2 PYGO2 LOXL3 LOXL3 OSR1 OSR1 FZD2 FZD2 LOC102729738 LOC102729738 LOC102747185 LOC102747185 WNT8A WNT8A EPHB3 EPHB3 TMEM107 TMEM107 SATB2 SATB2 WFIKKN1 WFIKKN1 TBX3 TBX3 PAK1IP1 PAK1IP1 BMPR1A BMPR1A TCF21 TCF21 WFIKKN2 WFIKKN2 ANP32B ANP32B MMP25 MMP25 WNT11 WNT11 WNT9B WNT9B MSX1 MSX1 LRRC32 LRRC32 SGPL1 SGPL1 INHBA INHBA LOC102736120 LOC102736120 ALX4 ALX4 LOC102727981 LOC102727981 LOC102727186 LOC102727186 LOC102744116 LOC102744116 LOC102729222 LOC102729222
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
INTUProtein inturned. (943 aa)
GDF11Growth/differentiation factor 11. (372 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
TIPARPTCDD-inducible poly [ADP-ribose] polymerase. (657 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2429 aa)
OSR2Protein odd-skipped-related 2 isoform X1. (312 aa)
MEOX2Homeobox protein MOX-2. (303 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
FOXF2Forkhead box protein F2. (263 aa)
CSRNP1Cysteine/serine-rich nuclear protein 1. (582 aa)
BCORBCL-6 corepressor isoform X1. (1757 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PYGO2Pygopus homolog 2. (369 aa)
LOXL3Lysyl oxidase homolog 3-like isoform X1. (392 aa)
OSR1Protein odd-skipped-related 1 isoform X1. (267 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
LOC102729738Lysyl oxidase homolog 3-like. (231 aa)
LOC102747185Homeobox protein DLX-5-like. (214 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EPHB3Ephrin type-B receptor 3. (883 aa)
TMEM107Transmembrane protein 107 isoform X1. (140 aa)
SATB2DNA-binding protein SATB. (342 aa)
WFIKKN1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (548 aa)
TBX3T-box transcription factor TBX3. (675 aa)
PAK1IP1P21-activated protein kinase-interacting protein 1. (391 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TCF21Transcription factor 21. (179 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (573 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (259 aa)
MMP25Matrix metalloproteinase-25. (559 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LRRC32Leucine-rich repeat-containing protein 32. (663 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
INHBAInhibin beta A chain. (424 aa)
LOC102736120Transcription factor AP-2-alpha-like. (431 aa)
ALX4Homeobox protein aristaless-like 4. (201 aa)
LOC102727981Homeobox protein aristaless-like 4-like. (278 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
LOC102744116Interferon regulatory factor 6-like. (227 aa)
LOC102729222Schwannomin-interacting protein 1-like. (146 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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