(51 nodes) SMAD protein signal transduction network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	LOC102732823	Vimentin-like isoform X1; Belongs to the intermediate filament family. (466 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)
	GDF11	Growth/differentiation factor 11. (372 aa)
	SLC33A1	Acetyl-coenzyme A transporter 1. (549 aa)
	AFP	Alpha-fetoprotein. (609 aa)
	JADE2	Protein Jade-2 isoform X2. (784 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1 isoform X2. (408 aa)
	SMAD9	Mothers against decapentaplegic homolog. (469 aa)
	HNF4A	Hepatocyte nuclear factor 4-alpha. (399 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1. (957 aa)
	HIPK2	Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
	INHBB	Inhibin beta B chain. (320 aa)
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)
	SUB1	Activated RNA polymerase II transcriptional coactivator p15 isoform X1. (126 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
	BMP8B	Bone morphogenetic protein 8B. (169 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha. (631 aa)
	ATOH8	Protein atonal homolog 8. (318 aa)
	GDF3	Growth/differentiation factor 3. (365 aa)
	LOC102730764	Mothers against decapentaplegic homolog 2-like. (227 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	CITED1	Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
	LOC102749080	Mothers against decapentaplegic homolog 5-like. (245 aa)
	LEFTY1	Left-right determination factor. (366 aa)
	LOC102745999	Left-right determination factor 1-like. (203 aa)
	BMP7	Bone morphogenetic protein 7-like. (312 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	BMP6	Bone morphogenetic protein 6. (189 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (662 aa)
	NODAL	Nodal homolog. (348 aa)
	FOS	Proto-oncogene c-Fos isoform X1. (380 aa)
	GDF15	Growth/differentiation factor 15. (308 aa)
	GDF5	Growth/differentiation factor 5. (499 aa)
	INHBA	Inhibin beta A chain. (424 aa)
	RBM14	RNA-binding protein 14 isoform X1. (669 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	GDF1	Embryonic growth/differentiation factor 1. (227 aa)
	LOC102749531	Growth/differentiation factor 2-like. (260 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (371 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	LOC102738254	Vimentin-like; Belongs to the intermediate filament family. (209 aa)
	LOC102750017	Mothers against decapentaplegic homolog 6-like. (181 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	INHBC	Inhibin beta C chain. (352 aa)
	INHBE	Inhibin beta E chain. (351 aa)
	LOC102735151	Bone morphogenetic protein 7-like. (139 aa)
	LOC102744413	Left-right determination factor 2-like. (165 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFP	HNF4A	A0A2U3XEG8	A0A2U3XSW6	Alpha-fetoprotein.	Hepatocyte nuclear factor 4-alpha.	0.769
AFP	LOC102740547	A0A2U3XEG8	A0A2U3Z034	Alpha-fetoprotein.	Bone morphogenetic protein 4-like isoform X1.	0.498
BMP2	BMP5	A0A2U3Z3S1	A0A2U3XA39	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 5 isoform X2.	0.497
BMP2	BMP6	A0A2U3Z3S1	A0A2U3YPC2	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 6.	0.924
BMP2	BMP7	A0A2U3Z3S1	A0A2U3YG58	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.592
BMP2	BMP8B	A0A2U3Z3S1	A0A2U3Y1R3	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 8B.	0.488
BMP2	GDF5	A0A2U3Z3S1	A0A2U3YTC5	Bone morphogenetic protein 2-like.	Growth/differentiation factor 5.	0.598
BMP2	LOC102726900	A0A2U3Z3S1	A0A2U3XYM0	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 7-like.	0.709
BMP2	LOC102730318	A0A2U3Z3S1	A0A2U3Z2G6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.621
BMP2	LOC102730764	A0A2U3Z3S1	A0A2U3Y552	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 2-like.	0.676
BMP2	LOC102735151	A0A2U3Z3S1	A0A2U3Z6A5	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.582
BMP2	LOC102740547	A0A2U3Z3S1	A0A2U3Z034	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 4-like isoform X1.	0.898
BMP2	LOC102749080	A0A2U3Z3S1	A0A2U3YCH5	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 5-like.	0.482
BMP2	LOC102750017	A0A2U3Z3S1	A0A2U3Z1Z6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 6-like.	0.743
BMP2	NODAL	A0A2U3Z3S1	A0A2U3YPZ3	Bone morphogenetic protein 2-like.	Nodal homolog.	0.407
BMP2	SMAD1	A0A2U3Z3S1	A0A2U3YKB3	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.800
BMP2	SMAD4	A0A2U3Z3S1	A0A2U3XTK1	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.820
BMP2	SMAD9	A0A2U3Z3S1	A0A2U3XRL8	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.638
BMP2	TGFB2	A0A2U3Z3S1	A0A2U3Y3M9	Bone morphogenetic protein 2-like.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.414
BMP3	SMAD4	A0A2U3Y1G5	A0A2U3XTK1	Bone morphogenetic protein 3; Belongs to the TGF-beta family.	Mothers against decapentaplegic homolog.	0.560