(12 nodes) Growth hormone receptor signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	LOC102749847	Tyrosine-protein kinase JAK1-like. (444 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	JAK3	Tyrosine-protein kinase. (1139 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	JAK2	Tyrosine-protein kinase. (952 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JAK2	JAK3	A0A2U3Y110	A0A2U3Z0Y0	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.919
JAK2	LOC102731864	A0A2U3Y110	A0A2U3Z7Y1	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5B-like.	0.931
JAK2	LOC102736516	A0A2U3Y110	A0A2U3YU20	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like.	0.929
JAK2	LOC102745161	A0A2U3Y110	A0A2U3Y4I5	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3-like.	0.970
JAK2	LOC102749847	A0A2U3Y110	A0A2U3Z702	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK1-like.	0.982
JAK2	LOC102751021	A0A2U3Y110	A0A2U3Z893	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1.	0.652
JAK2	SOCS2	A0A2U3Y110	A0A2U3XVP8	Tyrosine-protein kinase.	Suppressor of cytokine signaling 2.	0.964
JAK2	STAT3	A0A2U3Y110	A0A2U3Z463	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3-like.	0.979
JAK2	STAT5A	A0A2U3Y110	A0A2U3Z446	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5A.	0.987
JAK2	STAT5B	A0A2U3Y110	A0A2U3Y4J7	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5B.	0.931
JAK2	TYK2	A0A2U3Y110	A0A2U3YSI1	Tyrosine-protein kinase.	Non-receptor tyrosine-protein kinase TYK2-like.	0.985
JAK3	JAK2	A0A2U3Z0Y0	A0A2U3Y110	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.919
JAK3	LOC102731864	A0A2U3Z0Y0	A0A2U3Z7Y1	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5B-like.	0.922
JAK3	LOC102736516	A0A2U3Z0Y0	A0A2U3YU20	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like.	0.906
JAK3	LOC102745161	A0A2U3Z0Y0	A0A2U3Y4I5	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3-like.	0.941
JAK3	LOC102749847	A0A2U3Z0Y0	A0A2U3Z702	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK1-like.	0.982
JAK3	LOC102751021	A0A2U3Z0Y0	A0A2U3Z893	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1.	0.564
JAK3	SOCS2	A0A2U3Z0Y0	A0A2U3XVP8	Tyrosine-protein kinase.	Suppressor of cytokine signaling 2.	0.858
JAK3	STAT3	A0A2U3Z0Y0	A0A2U3Z463	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3-like.	0.941
JAK3	STAT5A	A0A2U3Z0Y0	A0A2U3Z446	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5A.	0.947