(26 nodes) Lung morphogenesis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRF	Serum response factor. (508 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	LOC102741200	Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
	TCF21	Transcription factor 21. (179 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (252 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (319 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (302 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	HHIP	Hedgehog-interacting protein-like. (662 aa)
	FOXF1	Forkhead box protein F1. (427 aa)
	DAG1	Dystroglycan isoform X1. (891 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	NODAL	Nodal homolog. (348 aa)
	CTSH	Pro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
	YAP1	Yorkie homolog. (326 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	LOC102740025	Protein sprouty homolog 2-like isoform X1. (315 aa)
	SEC24B	Protein transport protein Sec24B isoform X1. (1258 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (473 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (717 aa)
	HOXA5	Homeobox protein Hox-A5. (270 aa)
	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (741 aa)
	STK40	Serine/threonine-protein kinase 40 isoform X2. (440 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSH	CTSZ	A0A2U3YQN7	A0A2U3YGK5	Pro-cathepsin H; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.663
CTSZ	CTSH	A0A2U3YGK5	A0A2U3YQN7	Cathepsin Z; Belongs to the peptidase C1 family.	Pro-cathepsin H; Belongs to the peptidase C1 family.	0.663
FGF10	KRAS	A0A2U3XE64	A0A2U3X8L4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X2.	0.616
FGF10	LOC102727345	A0A2U3XE64	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.509
FGF10	LOC102740547	A0A2U3XE64	A0A2U3Z034	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4-like isoform X1.	0.769
FGF10	NKX2-1	A0A2U3XE64	A0A2U3YB70	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1.	0.489
FGF10	NOG	A0A2U3XE64	A0A2U3XEL8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.791
FOXA1	NKX2-1	A0A2U3XEU1	A0A2U3YB70	Hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.1.	0.581
FOXF1	LOC102727345	A0A2U3YL06	A0A2U3YND0	Forkhead box protein F1.	Transcription factor SOX-9-like.	0.411
FOXF1	LOC102740547	A0A2U3YL06	A0A2U3Z034	Forkhead box protein F1.	Bone morphogenetic protein 4-like isoform X1.	0.458
FOXF1	SRF	A0A2U3YL06	A0A2U3XZ49	Forkhead box protein F1.	Serum response factor.	0.536
FOXF1	TCF21	A0A2U3YL06	A0A2U3Y9R6	Forkhead box protein F1.	Transcription factor 21.	0.402
KRAS	FGF10	A0A2U3X8L4	A0A2U3XE64	GTPase KRas isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.616
KRAS	MAPK1	A0A2U3X8L4	A0A2U3YIW0	GTPase KRas isoform X2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.938
KRAS	YAP1	A0A2U3X8L4	A0A2U3YVG8	GTPase KRas isoform X2.	Yorkie homolog.	0.486
LOC102727345	FGF10	A0A2U3YND0	A0A2U3XE64	Transcription factor SOX-9-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.509
LOC102727345	FOXF1	A0A2U3YND0	A0A2U3YL06	Transcription factor SOX-9-like.	Forkhead box protein F1.	0.411
LOC102727345	LOC102740547	A0A2U3YND0	A0A2U3Z034	Transcription factor SOX-9-like.	Bone morphogenetic protein 4-like isoform X1.	0.577
LOC102727345	NKX2-1	A0A2U3YND0	A0A2U3YB70	Transcription factor SOX-9-like.	Homeobox protein Nkx-2.1.	0.499
LOC102727345	NOG	A0A2U3YND0	A0A2U3XEL8	Transcription factor SOX-9-like.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.650