(19 nodes) Lung epithelial cell differentiation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KRAS	GTPase KRas isoform X2. (188 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (473 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	RBBP9	Putative hydrolase RBBP9. (186 aa)
	SAV1	Protein salvador homolog 1. (384 aa)
	TMEM38B	Trimeric intracellular cation channel type B. (291 aa)
	HOXA5	Homeobox protein Hox-A5. (270 aa)
	GATA6	Transcription factor GATA-6. (287 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (273 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	AGR2	Anterior gradient protein 2 homolog isoform X1. (175 aa)
	SPDEF	SAM pointed domain-containing Ets transcription factor. (335 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (252 aa)
	LOC102749599	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B. (1155 aa)
	AIMP2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1. (320 aa)
	YAP1	Yorkie homolog. (326 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	A0A2U3XXS6	A0A2U3XEU1	Anterior gradient protein 2 homolog isoform X1.	Hepatocyte nuclear factor 3-alpha.	0.448
AGR2	SPDEF	A0A2U3XXS6	A0A2U3Y066	Anterior gradient protein 2 homolog isoform X1.	SAM pointed domain-containing Ets transcription factor.	0.580
FGF10	KRAS	A0A2U3XE64	A0A2U3X8L4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X2.	0.616
FGF10	LOC102727345	A0A2U3XE64	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.509
FGF10	NKX2-1	A0A2U3XE64	A0A2U3YB70	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1.	0.489
FOXA1	AGR2	A0A2U3XEU1	A0A2U3XXS6	Hepatocyte nuclear factor 3-alpha.	Anterior gradient protein 2 homolog isoform X1.	0.448
FOXA1	GATA6	A0A2U3XEU1	A0A2U3XNQ5	Hepatocyte nuclear factor 3-alpha.	Transcription factor GATA-6.	0.794
FOXA1	NKX2-1	A0A2U3XEU1	A0A2U3YB70	Hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.1.	0.581
FOXA1	NKX2-2	A0A2U3XEU1	A0A2U3XNW3	Hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.2.	0.442
FOXA1	SPDEF	A0A2U3XEU1	A0A2U3Y066	Hepatocyte nuclear factor 3-alpha.	SAM pointed domain-containing Ets transcription factor.	0.407
GATA6	FOXA1	A0A2U3XNQ5	A0A2U3XEU1	Transcription factor GATA-6.	Hepatocyte nuclear factor 3-alpha.	0.794
GATA6	LOC102727345	A0A2U3XNQ5	A0A2U3YND0	Transcription factor GATA-6.	Transcription factor SOX-9-like.	0.512
GATA6	NKX2-1	A0A2U3XNQ5	A0A2U3YB70	Transcription factor GATA-6.	Homeobox protein Nkx-2.1.	0.454
KRAS	FGF10	A0A2U3X8L4	A0A2U3XE64	GTPase KRas isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.616
KRAS	YAP1	A0A2U3X8L4	A0A2U3YVG8	GTPase KRas isoform X2.	Yorkie homolog.	0.486
LOC102727345	FGF10	A0A2U3YND0	A0A2U3XE64	Transcription factor SOX-9-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.509
LOC102727345	GATA6	A0A2U3YND0	A0A2U3XNQ5	Transcription factor SOX-9-like.	Transcription factor GATA-6.	0.512
LOC102727345	NKX2-1	A0A2U3YND0	A0A2U3YB70	Transcription factor SOX-9-like.	Homeobox protein Nkx-2.1.	0.499
NKX2-1	FGF10	A0A2U3YB70	A0A2U3XE64	Homeobox protein Nkx-2.1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.489
NKX2-1	FOXA1	A0A2U3YB70	A0A2U3XEU1	Homeobox protein Nkx-2.1.	Hepatocyte nuclear factor 3-alpha.	0.581