STRINGSTRING
FBXW7 FBXW7 SEC24B SEC24B LEF1 LEF1 SLC7A11 SLC7A11 LOC102740025 LOC102740025 SMCHD1 SMCHD1 FGF9 FGF9 JMJD6 JMJD6 KRAS KRAS LOC102735455 LOC102735455 CHI3L1 CHI3L1 LOC102743807 LOC102743807 LOC102742272 LOC102742272 LOC102744822 LOC102744822 FBXW9 FBXW9 LOC102742062 LOC102742062 FGF2 FGF2 LOC102749540 LOC102749540 LOC102740547 LOC102740547 RCN3 RCN3 SP3 SP3 LOC102741543 LOC102741543 CIC CIC LOC102726658 LOC102726658 HS6ST1 HS6ST1 YAP1 YAP1 PDGFRA PDGFRA AIMP2 AIMP2 ERRFI1 ERRFI1 LOC102726841 LOC102726841 MMP14 MMP14 RAB3A RAB3A CTSH CTSH FNDC3B FNDC3B NODAL NODAL FGF18 FGF18 NKIRAS1 NKIRAS1 LOC102727345 LOC102727345 GNG8 GNG8 DAG1 DAG1 LOC102749599 LOC102749599 NKIRAS2 NKIRAS2 FOXF1 FOXF1 ALDH1A2 ALDH1A2 ADAMTSL2 ADAMTSL2 HHIP HHIP MAPK1 MAPK1 WNT11 WNT11 CTSZ CTSZ ATXN1L ATXN1L ZIC3 ZIC3 RARG RARG ALDH1A3 ALDH1A3 SPRY1 SPRY1 NKX2-8 NKX2-8 TIMELESS TIMELESS NKX2-1 NKX2-1 PHOX2B PHOX2B EPAS1 EPAS1 TCF21 TCF21 BMPR1A BMPR1A LTBP3 LTBP3 GLI1 GLI1 DNAAF1 DNAAF1 CTGF CTGF LOC102741200 LOC102741200 BAG6 BAG6 HSPB11 HSPB11 HESX1 HESX1 RDH10 RDH10 SPDEF SPDEF PTK7 PTK7 SRF SRF STK40 STK40 LOC102747185 LOC102747185 LOC102729442 LOC102729442 AGR2 AGR2 LOC102729738 LOC102729738 FGF7 FGF7 MSC MSC LOXL3 LOXL3 EDA EDA LOC102735385 LOC102735385 BMPR2 BMPR2 PLOD3 PLOD3 HSD11B1 HSD11B1 CREB1 CREB1 NKX2-2 NKX2-2 GATA6 GATA6 HOXA5 HOXA5 TMEM38B TMEM38B RPGRIP1L RPGRIP1L SAV1 SAV1 RBBP9 RBBP9 SLC23A1 SLC23A1 SMPD3 SMPD3 SIX4 SIX4 ESRP2 ESRP2 EP300 EP300 PPP3R1 PPP3R1 FOXA1 FOXA1 NOG NOG FGF10 FGF10 CHD7 CHD7 LOX LOX FOXJ1 FOXJ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1258 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
SLC7A11Cystine/glutamate transporter-like isoform X2. (503 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1. (414 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102735455alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (215 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (384 aa)
LOC102743807Corticosteroid 11-beta-dehydrogenase isozyme 1-like. (118 aa)
LOC102742272Aldehyde dehydrogenase family 1 member A3-like. (127 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
LOC102742062T-box transcription factor TBX5-like. (308 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102749540Protein capicua homolog. (1444 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
RCN3Reticulocalbin-3. (328 aa)
SP3Transcription factor Sp3-like. (751 aa)
LOC102741543Zinc finger protein ZFPM2-like. (827 aa)
CICProtein capicua homolog. (134 aa)
LOC102726658Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (176 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (202 aa)
YAP1Yorkie homolog. (326 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
AIMP2Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1. (320 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (460 aa)
LOC102726841A disintegrin and metalloproteinase with thrombospondin motifs 2-like. (348 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1155 aa)
NODALNodal homolog. (348 aa)
FGF18Fibroblast growth factor 18. (116 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DAG1Dystroglycan isoform X1. (891 aa)
LOC102749599Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X2. (191 aa)
FOXF1Forkhead box protein F1. (427 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
ADAMTSL2ADAMTS-like protein 2. (955 aa)
HHIPHedgehog-interacting protein-like. (662 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
ATXN1LAtaxin-1-like isoform X1. (688 aa)
ZIC3Zinc finger protein ZIC 3. (465 aa)
RARGRetinoic acid receptor gamma isoform X1. (486 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (261 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
NKX2-8Homeobox protein Nkx-2.8. (239 aa)
TIMELESSProtein timeless homolog. (1212 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
EPAS1Endothelial PAS domain-containing protein 1. (865 aa)
TCF21Transcription factor 21. (179 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
DNAAF1Dynein assembly factor 1, axonemal. (625 aa)
CTGFConnective tissue growth factor. (211 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1163 aa)
HSPB11Intraflagellar transport protein 25 homolog. (143 aa)
HESX1Homeobox expressed in ES cells 1. (185 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SPDEFSAM pointed domain-containing Ets transcription factor. (335 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRFSerum response factor. (508 aa)
STK40Serine/threonine-protein kinase 40 isoform X2. (440 aa)
LOC102747185Homeobox protein DLX-5-like. (214 aa)
LOC102729442Protein Hikeshi. (197 aa)
AGR2Anterior gradient protein 2 homolog isoform X1. (175 aa)
LOC102729738Lysyl oxidase homolog 3-like. (231 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MSCMusculin. (198 aa)
LOXL3Lysyl oxidase homolog 3-like isoform X1. (392 aa)
EDAectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (390 aa)
LOC102735385ATP-binding cassette sub-family A member 12-like. (1103 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (741 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1. (216 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
GATA6Transcription factor GATA-6. (287 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
RPGRIP1LProtein fantom isoform X2. (1244 aa)
SAV1Protein salvador homolog 1. (384 aa)
RBBP9Putative hydrolase RBBP9. (186 aa)
SLC23A1Solute carrier family 23 member 1. (605 aa)
SMPD3Sphingomyelin phosphodiesterase 3 isoform X1. (653 aa)
SIX4Homeobox protein SIX4. (778 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
EP300Histone acetyltransferase p300. (2425 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2429 aa)
LOXProtein-lysine 6-oxidase isoform X1. (415 aa)
FOXJ1Forkhead box protein J1. (421 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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