STRINGSTRING
GZF1 GZF1 LOC102740025 LOC102740025 PKD2 PKD2 LEF1 LEF1 SEC24B SEC24B SFRP2 SFRP2 LGR4 LGR4 KRAS KRAS LRRC1 LRRC1 RET RET ALCAM ALCAM ARL13B ARL13B GLMN GLMN STARD13 STARD13 WNT1 WNT1 VDR VDR NKX3-1 NKX3-1 FGF10 FGF10 NOG NOG FOXA1 FOXA1 LOC102741253 LOC102741253 PPP3R1 PPP3R1 ESRP2 ESRP2 STK3 STK3 GREM1 GREM1 LOC102731945 LOC102731945 ST14 ST14 LOC102731342 LOC102731342 HOXA11 HOXA11 LIAS LIAS DVL1 DVL1 IRX3 IRX3 LHX1 LHX1 ILK ILK HOXA5 HOXA5 SALL4 SALL4 SRC SRC SEMA4C SEMA4C TBX6 TBX6 LOC102726488 LOC102726488 TBX20 TBX20 DLG2 DLG2 SMAD4 SMAD4 LOC102747957 LOC102747957 FZD3 FZD3 STK4 STK4 MTHFR MTHFR MSC MSC TRIM71 TRIM71 OSR1 OSR1 FZD2 FZD2 LOC102731974 LOC102731974 SOSTDC1 SOSTDC1 CCM2 CCM2 RALA RALA TRAF6 TRAF6 SRF SRF PTK7 PTK7 FKBP14 FKBP14 PRKACB PRKACB CLIC4 CLIC4 RDH10 RDH10 NRARP NRARP HESX1 HESX1 LOC102745156 LOC102745156 MED12 MED12 PHB2 PHB2 PRKX PRKX DVL3 DVL3 PTCH1 PTCH1 LY6G5B LY6G5B CSNK2B CSNK2B HIF1A HIF1A KAT2A KAT2A PLEKHH1 PLEKHH1 VASP VASP DVL2 DVL2 IRX1 IRX1 SOX8 SOX8 TBX3 TBX3 HS2ST1 HS2ST1 TACSTD2 TACSTD2 PAK1 PAK1 LOC102741200 LOC102741200 KDM5B KDM5B DNAAF1 DNAAF1 PHACTR4 PHACTR4 TCF21 TCF21 CITED1 CITED1 NKX2-1 NKX2-1 BCL10 BCL10 PML PML TIMELESS TIMELESS GATA3 GATA3 SPRY1 SPRY1 RARG RARG CC2D2A CC2D2A ZIC3 ZIC3 SOX17 SOX17 MTSS1 MTSS1 SPINT1 SPINT1 DLL4 DLL4 LOC102746898 LOC102746898 CTSZ CTSZ WNT6 WNT6 LOC102746003 LOC102746003 WNT11 WNT11 ACVRL1 ACVRL1 EPHA4 EPHA4 EYA1 EYA1 WNT9B WNT9B HHIP HHIP HAND1 HAND1 FUZ FUZ FOXF1 FOXF1 LGR5 LGR5 MST1 MST1 DAG1 DAG1 DLL1 DLL1 COMMD5 COMMD5 MEF2C MEF2C GRHL3 GRHL3 LHX2 LHX2 LOC102727345 LOC102727345 DDR1 DDR1 CTNNBIP1 CTNNBIP1 NODAL NODAL CSF1 CSF1 CTSH CTSH KIF26B KIF26B ARHGAP35 ARHGAP35 FOXH1 FOXH1 LOC102729478 LOC102729478 MMP14 MMP14 SFRP1 SFRP1 MED1 MED1 TCAP TCAP MICAL2 MICAL2 TMEM59L TMEM59L YAP1 YAP1 LOC102729692 LOC102729692 IFT57 IFT57 ASB2 ASB2 NTN1 NTN1 NOTCH2 NOTCH2 MEGF8 MEGF8 LOC102730307 LOC102730307 MKS1 MKS1 ABL1 ABL1 CITED2 CITED2 KDM2B KDM2B LOC102749531 LOC102749531 LOC102745732 LOC102745732 LOC102740547 LOC102740547 WT1 WT1 CTHRC1 CTHRC1 LOC102737253 LOC102737253 GBX2 GBX2 LOC102730318 LOC102730318 FGF2 FGF2 LOC102746959 LOC102746959 SPINT2 SPINT2 LOC102733342 LOC102733342 BMP2 BMP2 LOC102737660 LOC102737660 LOC102744822 LOC102744822 TIE1 TIE1 LOC102750604 LOC102750604 LOC102727186 LOC102727186 SHH SHH LOC102732559 LOC102732559 LOC102745028 LOC102745028
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GZF1GDNF-inducible zinc finger protein 1. (719 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
PKD2Polycystin-2. (935 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1258 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
KRASGTPase KRas isoform X2. (188 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
ALCAMCD166 antigen isoform X3. (133 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (430 aa)
GLMNGlomulin. (521 aa)
STARD13stAR-related lipid transfer protein 13. (1123 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
VDRVitamin D3 receptor. (427 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
LOC102741253Amphiregulin-like. (253 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
GREM1Gremlin. (184 aa)
LOC102731945Suppressor of fused homolog. (106 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (827 aa)
LOC102731342Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
HOXA11Homeobox protein Hox-A11. (321 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (538 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
SALL4Sal-like protein 4. (1052 aa)
SRCTyrosine-protein kinase. (536 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
TBX6T-box transcription factor TBX6. (436 aa)
LOC102726488Iroquois-class homeodomain protein IRX-2-like. (414 aa)
TBX20T-box transcription factor TBX20. (447 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC102747957Meckel syndrome type 1 protein-like. (318 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
MSCMusculin. (198 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (369 aa)
OSR1Protein odd-skipped-related 1 isoform X1. (267 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
LOC102731974Coiled-coil domain-containing protein 103-like. (242 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
CCM2Malcavernin. (447 aa)
RALARas-related protein Ral-A. (206 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SRFSerum response factor. (508 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
FKBP14Peptidylprolyl isomerase. (211 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CLIC4Chloride intracellular channel protein 4. (135 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
HESX1Homeobox expressed in ES cells 1. (185 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (812 aa)
PHB2Prohibitin. (299 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
PTCH1Protein patched homolog 1. (1301 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
PLEKHH1Pleckstrin homology domain-containing family H member 1. (1365 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
IRX1Iroquois-class homeodomain protein IRX-1-like. (391 aa)
SOX8Transcription factor SOX-8. (412 aa)
TBX3T-box transcription factor TBX3. (675 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (302 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
KDM5BLysine-specific demethylase 5B. (872 aa)
DNAAF1Dynein assembly factor 1, axonemal. (625 aa)
PHACTR4Phosphatase and actin regulator. (715 aa)
TCF21Transcription factor 21. (179 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
PMLProtein PML. (880 aa)
TIMELESSProtein timeless homolog. (1212 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
RARGRetinoic acid receptor gamma isoform X1. (486 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A. (1617 aa)
ZIC3Zinc finger protein ZIC 3. (465 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
MTSS1Metastasis suppressor protein 1 isoform X3. (529 aa)
SPINT1Kunitz-type protease inhibitor 1. (511 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
LOC102746898Protein GREB1-like. (1593 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
LOC102746003Clusterin-associated protein 1-like. (216 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
HHIPHedgehog-interacting protein-like. (662 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
FUZProtein fuzzy homolog isoform X1. (418 aa)
FOXF1Forkhead box protein F1. (427 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (598 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
DAG1Dystroglycan isoform X1. (891 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
COMMD5COMM domain-containing protein 5. (224 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
GRHL3Grainyhead-like protein 3 homolog. (602 aa)
LHX2LIM/homeobox protein Lhx2-like isoform X1. (406 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
DDR1Epithelial discoidin domain-containing receptor 1 isoform X1. (921 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
NODALNodal homolog. (348 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
KIF26BKinesin-like protein KIF26B-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
FOXH1Forkhead box protein H1. (360 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
TCAPTelethonin isoform X2. (167 aa)
MICAL2Protein-methionine sulfoxide oxidase MICAL2. (88 aa)
TMEM59LTransmembrane protein 59-like. (350 aa)
YAP1Yorkie homolog. (326 aa)
LOC102729692Ras-interacting protein 1-like. (208 aa)
IFT57Intraflagellar transport protein 57 homolog. (429 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (630 aa)
NTN1Netrin-1-like. (402 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2068 aa)
LOC102730307CUB and sushi domain-containing protein 1-like. (828 aa)
MKS1Meckel syndrome type 1 protein. (262 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
KDM2BLysine-specific demethylase 2B. (637 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
WT1Wilms tumor protein-like. (413 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
LOC102737253Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
GBX2Homeobox protein GBX-2. (251 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102746959LIM domain transcription factor LMO4-like isoform X1. (165 aa)
SPINT2Kunitz-type protease inhibitor 2. (252 aa)
LOC102733342Bromodomain-containing protein 2-like isoform X1. (803 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102737660Leucine-rich repeat-containing G-protein coupled receptor 5-like. (315 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (1015 aa)
LOC102750604E3 ubiquitin-protein ligase TRIM71-like. (536 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
SHHSonic hedgehog protein-like. (286 aa)
LOC102732559Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (20%) [HD]