(13 nodes) Neuroepithelial cell differentiation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	MAP1B	Microtubule-associated protein 1B-like isoform X1. (2348 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	LHX3	LIM/homeobox protein Lhx3 isoform X1. (403 aa)
	OTP	Homeobox protein orthopedia. (325 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	TMEM231	Transmembrane protein 231. (316 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	BCCIP	BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (315 aa)
	B9D1	B9 domain-containing protein 1. (204 aa)
	EMX1	Homeobox protein EMX1. (295 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9D1	TMEM231	A0A2U3XK55	A0A2U3YI50	B9 domain-containing protein 1.	Transmembrane protein 231.	0.873
BMP2	FGF2	A0A2U3Z3S1	A0A2U3Z312	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.722
DLL1	JAG1	A0A2U3YLU9	A0A2U3XZY3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.490
FGF2	BMP2	A0A2U3Z312	A0A2U3Z3S1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2-like.	0.722
FGF2	JAG1	A0A2U3Z312	A0A2U3XZY3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
JAG1	DLL1	A0A2U3XZY3	A0A2U3YLU9	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.490
JAG1	FGF2	A0A2U3XZY3	A0A2U3Z312	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.486
TMEM231	B9D1	A0A2U3YI50	A0A2U3XK55	Transmembrane protein 231.	B9 domain-containing protein 1.	0.873