(34 nodes) Negative regulation of response to cytokine stimulus network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	OTUD4	OTU domain-containing protein 4. (1110 aa)
	YTHDF3	YTH domain family protein 3-like isoform X1. (531 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	LOC102734343	Single Ig IL-1-related receptor-like. (229 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (468 aa)
	IL1RN	Interleukin-1. (176 aa)
	OTOP1	Otopetrin-1. (418 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7 isoform X1. (285 aa)
	LOC102739627	Interleukin-1. (155 aa)
	RFFL	E3 ubiquitin-protein ligase rififylin. (298 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
	NOL3	Nucleolar protein 3. (212 aa)
	STAT2	Signal transducer and activator of transcription. (854 aa)
	GPS2	G protein pathway suppressor 2 isoform X1. (327 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (503 aa)
	CACTIN	Cactin. (749 aa)
	GAS6	Growth arrest-specific protein 6. (646 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	BIRC7	Baculoviral IAP repeat-containing protein 7. (287 aa)
	IL1R2	Interleukin-1 receptor type 2. (414 aa)
	TRAIP	TRAF-interacting protein. (469 aa)
	F2RL1	Proteinase-activated receptor 2. (415 aa)
	ADAR	Double-stranded RNA-specific adenosine deaminase. (1145 aa)
	SAMHD1	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (627 aa)
	ISG15	Ubiquitin-like protein ISG15. (169 aa)
	TTLL12	Tubulin--tyrosine ligase-like protein 12. (645 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	RABGEF1	Rab5 GDP/GTP exchange factor. (491 aa)
	STAP1	Signal-transducing adaptor protein 1. (332 aa)
	LOC102741936	Trem-like transcript 1 protein-like. (128 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ECM1	LOW QUALITY PROTEIN: extracellular matrix protein 1. (550 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	ISG15	A0A2U3XTV3	A0A2U3XMC4	Double-stranded RNA-specific adenosine deaminase.	Ubiquitin-like protein ISG15.	0.496
ADAR	SAMHD1	A0A2U3XTV3	A0A2U3XQH3	Double-stranded RNA-specific adenosine deaminase.	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1.	0.525
ADAR	STAT2	A0A2U3XTV3	A0A2U3YBI2	Double-stranded RNA-specific adenosine deaminase.	Signal transducer and activator of transcription.	0.481
BIRC7	XIAP	A0A2U3Y2P0	A0A2U3YG34	Baculoviral IAP repeat-containing protein 7.	E3 ubiquitin-protein ligase XIAP-like isoform X1.	0.910
CACTIN	TTLL12	A0A2U3Y4X9	A0A2U3XLT8	Cactin.	Tubulin--tyrosine ligase-like protein 12.	0.482
CNOT7	YTHDF3	A0A2U3YMF5	A0A2U3Z955	CCR4-NOT transcription complex subunit 7 isoform X1.	YTH domain family protein 3-like isoform X1.	0.662
GAS6	LOC102741936	A0A2U3Y4W6	A0A2U3XCU2	Growth arrest-specific protein 6.	Trem-like transcript 1 protein-like.	0.481
GAS6	TREM2	A0A2U3Y4W6	A0A2U3XCQ7	Growth arrest-specific protein 6.	Triggering receptor expressed on myeloid cells 2.	0.481
IL1R2	IL1RN	A0A2U3Y1F0	A0A2U3YYW9	Interleukin-1 receptor type 2.	Interleukin-1.	0.945
IL1R2	LOC102739627	A0A2U3Y1F0	A0A2U3YM53	Interleukin-1 receptor type 2.	Interleukin-1.	0.657
IL1RN	IL1R2	A0A2U3YYW9	A0A2U3Y1F0	Interleukin-1.	Interleukin-1 receptor type 2.	0.945
IL1RN	LOC102739627	A0A2U3YYW9	A0A2U3YM53	Interleukin-1.	Interleukin-1.	0.474
ISG15	ADAR	A0A2U3XMC4	A0A2U3XTV3	Ubiquitin-like protein ISG15.	Double-stranded RNA-specific adenosine deaminase.	0.496
ISG15	RABGEF1	A0A2U3XMC4	A0A2U3XEP3	Ubiquitin-like protein ISG15.	Rab5 GDP/GTP exchange factor.	0.933
ISG15	SAMHD1	A0A2U3XMC4	A0A2U3XQH3	Ubiquitin-like protein ISG15.	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1.	0.527
ISG15	STAT2	A0A2U3XMC4	A0A2U3YBI2	Ubiquitin-like protein ISG15.	Signal transducer and activator of transcription.	0.758
LOC102739627	IL1R2	A0A2U3YM53	A0A2U3Y1F0	Interleukin-1.	Interleukin-1 receptor type 2.	0.657
LOC102739627	IL1RN	A0A2U3YM53	A0A2U3YYW9	Interleukin-1.	Interleukin-1.	0.474
LOC102741936	GAS6	A0A2U3XCU2	A0A2U3Y4W6	Trem-like transcript 1 protein-like.	Growth arrest-specific protein 6.	0.481
LOC102741936	TREM2	A0A2U3XCU2	A0A2U3XCQ7	Trem-like transcript 1 protein-like.	Triggering receptor expressed on myeloid cells 2.	0.742