(50 nodes) Kidney morphogenesis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WWTR1	WW domain-containing transcription regulator protein 1. (144 aa)
	DLG2	Disks large homolog 2 isoform X1. (905 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	OSR1	Protein odd-skipped-related 1 isoform X1. (267 aa)
	SIX2	Homeobox protein SIX2. (294 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
	PTCH1	Protein patched homolog 1. (1301 aa)
	IRX1	Iroquois-class homeodomain protein IRX-1-like. (391 aa)
	SOX8	Transcription factor SOX-8. (412 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (302 aa)
	TACSTD2	Tumor-associated calcium signal transducer 2. (323 aa)
	TCF21	Transcription factor 21. (179 aa)
	GCNT3	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3. (440 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	LOC102746898	Protein GREB1-like. (1593 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
	COMMD5	COMM domain-containing protein 5. (224 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (81 aa)
	KIF26B	Kinesin-like protein KIF26B-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa)
	SALL1	Sal-like protein 1-like. (1314 aa)
	TMEM59L	Transmembrane protein 59-like. (350 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	WT1	Wilms tumor protein-like. (413 aa)
	LOC102744093	WW domain-containing transcription regulator protein 1-like. (286 aa)
	LOC102737253	Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	GZF1	GDNF-inducible zinc finger protein 1. (719 aa)
	LOC102726488	Iroquois-class homeodomain protein IRX-2-like. (414 aa)
	ILK	Integrin-linked protein kinase isoform X1. (452 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	IRX3	Iroquois-class homeodomain protein IRX-3. (538 aa)
	HOXA11	Homeobox protein Hox-A11. (321 aa)
	LOC102731342	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
	GREM1	Gremlin. (184 aa)
	PKD2	Polycystin-2. (935 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
	FOXJ1	Forkhead box protein J1. (421 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	CALB1	Calbindin. (261 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	FGF10	A0A2U3Z3S1	A0A2U3XE64	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.557
BMP2	FGF2	A0A2U3Z3S1	A0A2U3Z312	Bone morphogenetic protein 2-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.722
BMP2	GREM1	A0A2U3Z3S1	A0A2U3XFV2	Bone morphogenetic protein 2-like.	Gremlin.	0.820
BMP2	LOC102727345	A0A2U3Z3S1	A0A2U3YND0	Bone morphogenetic protein 2-like.	Transcription factor SOX-9-like.	0.549
BMP2	LOC102740547	A0A2U3Z3S1	A0A2U3Z034	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 4-like isoform X1.	0.898
BMP2	LOC102744822	A0A2U3Z3S1	A0A2U3Z5B6	Bone morphogenetic protein 2-like.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.476
BMP2	NOG	A0A2U3Z3S1	A0A2U3XEL8	Bone morphogenetic protein 2-like.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.971
BMP2	SMAD4	A0A2U3Z3S1	A0A2U3XTK1	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.820
CALB1	LHX1	A0A2U3XDD1	A0A2U3XMR7	Calbindin.	LIM/homeobox protein Lhx1.	0.448
CALB1	LOC102727345	A0A2U3XDD1	A0A2U3YND0	Calbindin.	Transcription factor SOX-9-like.	0.482
EYA1	GATA3	A0A2U3YJ16	A0A2U3YCA3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.430
EYA1	LHX1	A0A2U3YJ16	A0A2U3XMR7	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	LIM/homeobox protein Lhx1.	0.429
EYA1	LOC102737253	A0A2U3YJ16	A0A2U3Z218	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Glial cell line-derived neurotrophic factor-like isoform X1.	0.682
EYA1	LOC102740547	A0A2U3YJ16	A0A2U3Z034	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Bone morphogenetic protein 4-like isoform X1.	0.400
EYA1	SALL1	A0A2U3YJ16	A0A2U3YRN3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Sal-like protein 1-like.	0.495
EYA1	SIX1	A0A2U3YJ16	A0A2U3XF53	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX1.	0.740
EYA1	SIX2	A0A2U3YJ16	A0A2U3XZ28	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX2.	0.740
EYA1	WNT9B	A0A2U3YJ16	A0A2U3YJ26	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.545
EYA1	WT1	A0A2U3YJ16	A0A2U3Z0G8	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Wilms tumor protein-like.	0.484
FGF10	BMP2	A0A2U3XE64	A0A2U3Z3S1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2-like.	0.557