STRINGSTRING
PGP PGP LOC102731486 LOC102731486 AKT3 AKT3 IFNG IFNG LOC102746290 LOC102746290 ABCD1 ABCD1 FOXK2 FOXK2 PIBF1 PIBF1 MIDN MIDN FAM173B FAM173B HDAC4 HDAC4 CD74 CD74 BEND3 BEND3 LOC102749081 LOC102749081 AVPR1B AVPR1B SEC14L2 SEC14L2 SEC14L4 SEC14L4 PANK2 PANK2 PRKAG2 PRKAG2 MID1IP1 MID1IP1 LONP2 LONP2 GUCA2A GUCA2A POU1F1 POU1F1 SLC7A11 SLC7A11 DNM1L DNM1L SNAI2 SNAI2 ABCD2 ABCD2 FAM3C FAM3C BMP5 BMP5 RANBP2 RANBP2 CAV1 CAV1 GUCA1A GUCA1A TREM2 TREM2 LOC102741936 LOC102741936 GUCA1B GUCA1B BCKDK BCKDK EP300 EP300 KAT2B KAT2B NR1H3 NR1H3 METTL20 METTL20 P2RY6 P2RY6 LACC1 LACC1 PDK4 PDK4 PDK3 PDK3 DDIT4 DDIT4 CRY1 CRY1 IGF1 IGF1 PMAIP1 PMAIP1 LOC102751010 LOC102751010 SNAI1 SNAI1 TTC39A TTC39A FAM132A FAM132A TSPO TSPO FGFR4 FGFR4 MAS1 MAS1 ACMSD ACMSD PLA2G3 PLA2G3 GUCA2B GUCA2B ADIPOR1 ADIPOR1 LOC102727300 LOC102727300 LHCGR LHCGR GCKR GCKR LOC102744936 LOC102744936 LOC102750030 LOC102750030 LOC102750518 LOC102750518 LOC102740880 LOC102740880 CBFA2T3 CBFA2T3 LOC102746559 LOC102746559 JMJD8 JMJD8 GPD1 GPD1 LOC102727494 LOC102727494 LOC102744822 LOC102744822 C1QTNF6 C1QTNF6 IGFBP4 IGFBP4 FOXO1 FOXO1 LOC102738763 LOC102738763 STAT3 STAT3 TREX1 TREX1 BMP2 BMP2 LOC102739775 LOC102739775 INS INS LOC102746954 LOC102746954 LOC102746352 LOC102746352 PPARA PPARA TYSND1 TYSND1 LOC102726862 LOC102726862 OGT OGT DKKL1 DKKL1 LOC102729806 LOC102729806 GPER1 GPER1 NR1H2 NR1H2 LOC102751087 LOC102751087 SEC14L5 SEC14L5 PDK2 PDK2 RD3 RD3 LOC102748816 LOC102748816 LOC102738536 LOC102738536 TFF3 TFF3 LOC102742922 LOC102742922 ARV1 ARV1 DKK3 DKK3 PARK7 PARK7 DGKQ DGKQ SIRT5 SIRT5 DYRK2 DYRK2 NR1D1 NR1D1 SIRT7 SIRT7 HTR2A HTR2A SERPINA12 SERPINA12 PTPN2 PTPN2 DNAJC30 DNAJC30 FBP1 FBP1 SLC2A6 SLC2A6 PARP1 PARP1 LOC102746417 LOC102746417 LDLR LDLR LOC102747801 LOC102747801 MST1 MST1 FLCN FLCN LOC102737520 LOC102737520 LOC102727345 LOC102727345 LOC102737823 LOC102737823 SIRT4 SIRT4 SPHK2 SPHK2 ELOVL5 ELOVL5 SEC14L3 SEC14L3 FIS1 FIS1 NUPR1 NUPR1 ZBTB20 ZBTB20 LOC102731157 LOC102731157 H6PD H6PD PID1 PID1 NCOR1 NCOR1 FMO4 FMO4 C1QTNF1 C1QTNF1 BMP6 BMP6 PTH PTH PPARGC1A PPARGC1A LOC102739094 LOC102739094 GCK GCK GNMT GNMT LOC102738400 LOC102738400 P2RX7 P2RX7 PPTC7 PPTC7 ARL2 ARL2 SLC45A3 SLC45A3 PPARD PPARD EGR1 EGR1 ZMPSTE24 ZMPSTE24 MFSD2A MFSD2A PRMT3 PRMT3 LPCAT3 LPCAT3 AKT1 AKT1 TNF TNF HIF1A HIF1A KAT2A KAT2A LOC102745161 LOC102745161 SIRT6 SIRT6 DUSP12 DUSP12 SLC4A1 SLC4A1 AAED1 AAED1 ATCAY ATCAY TP53 TP53 ACADVL ACADVL GPLD1 GPLD1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGPPhosphoglycolate phosphatase-like; Belongs to the HAD-like hydrolase superfamily. (289 aa)
LOC102731486Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC10274629025-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (508 aa)
ABCD1ATP-binding cassette sub-family D member 1. (825 aa)
FOXK2Forkhead box protein K2. (540 aa)
PIBF1Progesterone-induced-blocking factor 1. (757 aa)
MIDNMidnolin. (489 aa)
FAM173BProtein FAM173B. (148 aa)
HDAC4Histone deacetylase 4-like. (667 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
BEND3BEN domain-containing protein 3. (828 aa)
LOC102749081Nuclear receptor corepressor 2-like. (252 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
SEC14L2SEC14-like protein 2 isoform X1. (403 aa)
SEC14L4SEC14-like protein 4 isoform X1. (406 aa)
PANK2Pantothenate kinase 2, mitochondrial isoform X1. (449 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
LONP2Lon protease homolog 2, peroxisomal. (660 aa)
GUCA2AGuanylin. (111 aa)
POU1F1POU domain protein. (317 aa)
SLC7A11Cystine/glutamate transporter-like isoform X2. (503 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ABCD2ATP-binding cassette sub-family D member 2 isoform X2. (742 aa)
FAM3CProtein FAM3C. (227 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (3100 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GUCA1AGuanylyl cyclase-activating protein 1. (205 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
GUCA1BGuanylyl cyclase-activating protein 2. (201 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
EP300Histone acetyltransferase p300. (2425 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
METTL20Methyltransferase-like protein 20. (266 aa)
P2RY6P2Y purinoceptor 6. (328 aa)
LACC1Laccase domain-containing protein 1. (118 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
PDK3Protein-serine/threonine kinase. (252 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
CRY1Cryptochrome-1. (587 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
TTC39ATetratricopeptide repeat protein 39A isoform X3. (550 aa)
FAM132AProtein FAM132A. (310 aa)
TSPOTranslocator protein. (170 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
MAS1Proto-oncogene Mas isoform X1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (265 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
GUCA2BGuanylate cyclase activator 2B. (110 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
LOC102727300Battenin-like. (109 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
GCKRLOW QUALITY PROTEIN: glucokinase (Hexokinase 4) regulator. (482 aa)
LOC102744936Fatty acid-binding protein, epidermal-like. (81 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
CBFA2T3Protein CBFA2T3-like. (343 aa)
LOC102746559Apolipoprotein B-100-like. (322 aa)
JMJD8jmjC domain-containing protein 8. (296 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
LOC102727494Nuclear receptor corepressor 2-like. (227 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (265 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
LOC102738763Nicotinamide N-methyltransferase-like. (264 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102746954Fructose-2,6-bisphosphatase TIGAR. (270 aa)
LOC102746352Lon protease homolog 2, peroxisomal-like; Belongs to the peptidase S16 family. (206 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
TYSND1Peroxisomal leader peptide-processing protease. (356 aa)
LOC102726862UDP-xylose and UDP-N-acetylglucosamine transporter-like. (262 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
DKKL1Dickkopf-like protein 1 isoform X3. (237 aa)
LOC102729806WD repeat-containing protein 5-like. (334 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NR1H2Oxysterols receptor LXR-beta. (457 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
SEC14L5SEC14-like protein 5-like. (448 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
RD3Protein RD3. (196 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
LOC102738536Insulin-like growth factor-binding protein 3-like. (120 aa)
TFF3Trefoil factor 3. (80 aa)
LOC102742922SEC14-like protein 5-like. (268 aa)
ARV1Protein ARV1. (281 aa)
DKK3Dickkopf-related protein 3. (286 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
DGKQDiacylglycerol kinase. (913 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial. (202 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2-like. (528 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (251 aa)
HTR2A5-hydroxytryptamine receptor 2A. (263 aa)
SERPINA12Serpin A12; Belongs to the serpin family. (416 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
DNAJC30dnaJ homolog subfamily C member 30. (226 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
SLC2A6Solute carrier family 2, facilitated glucose transporter member 6 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PARP1Poly [ADP-ribose] polymerase. (686 aa)
LOC102746417Long-chain fatty acid transport protein 4-like. (346 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
FLCNFolliculin. (579 aa)
LOC102737520Cytochrome c oxidase assembly protein COX11, mitochondrial-like isoform X1. (275 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
SEC14L3SEC14-like protein 3-like isoform X1. (400 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X2. (668 aa)
LOC102731157ARF GTPase-activating protein GIT1-like. (191 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein. (789 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein. (203 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2435 aa)
FMO4Flavin-containing monooxygenase. (177 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (279 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
LOC102739094Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
GCKPhosphotransferase. (391 aa)
GNMTGlycine N-methyltransferase. (295 aa)
LOC102738400Annexin. (345 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (304 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MFSD2AMajor facilitator superfamily domain-containing protein 2A isoform X1. (529 aa)
PRMT3Protein arginine N-methyltransferase 3 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (529 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
DUSP12Dual specificity protein phosphatase 12. (340 aa)
SLC4A1Anion exchange protein. (899 aa)
AAED1Thioredoxin-like protein AAED1. (232 aa)
ATCAYCaytaxin. (371 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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