(53 nodes) Chemokine-mediated signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCL7	LOW QUALITY PROTEIN: c-C motif chemokine 7. (99 aa)
	CCL1	c-C motif chemokine 1. (94 aa)
	DARC	Duffy antigen/chemokine receptor isoform X1. (331 aa)
	LOC102747594	c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CCL24	c-C motif chemokine 24. (119 aa)
	CX3CR1	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC102726694	C-C motif chemokine. (121 aa)
	LOC102725792	C-C motif chemokine. (92 aa)
	CXCL6	C-X-C motif chemokine. (113 aa)
	PF4	C-X-C motif chemokine. (106 aa)
	PPBP	LOW QUALITY PROTEIN: platelet basic protein. (119 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	LOC102741936	Trem-like transcript 1 protein-like. (128 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	CXCL12	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	GPR75	Probable G-protein coupled receptor 75. (540 aa)
	XCL1	Lymphotactin. (112 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	CXCL13	c-X-C motif chemokine 13. (110 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	LOC102740920	C-C motif chemokine. (91 aa)
	LOC102747754	Fractalkine-like. (221 aa)
	CXCR6	c-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	CCR9	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	LOC102733354	c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC102748833	Tyrosine-protein kinase. (375 aa)
	LOC102745236	Chemokine C-C motif receptor-like 2-like; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	MPL	Thrombopoietin receptor. (543 aa)
	CCR5	c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CCR1	c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	CCL20	C-C motif chemokine. (89 aa)
	CCR6	c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	CCR3	c-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	CCL14	c-C motif chemokine 14. (96 aa)
	CXCR3	c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	CX3CL1	Fractalkine. (181 aa)
	CCL17	c-C motif chemokine 17. (99 aa)
	LOC102735431	C-C motif chemokine. (93 aa)
	LOC102734017	c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	CXCL11	c-X-C motif chemokine 11. (100 aa)
	CCR7	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	CCL26	C-C motif chemokine. (94 aa)
	CCR4	c-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	ACKR4	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	THPO	LOW QUALITY PROTEIN: thrombopoietin. (352 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	CCL21	c-C motif chemokine 21. (137 aa)
	CCL16	c-C motif chemokine 16. (108 aa)
	CCL19	C-C motif chemokine. (100 aa)
	XCR1	Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	CXCR5	c-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	CCL13	C-C motif chemokine. (98 aa)
	CCL8	c-C motif chemokine 8. (99 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR3	CCL16	A0A2U3Y5X3	A0A2U3Z2Y3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-C motif chemokine 16.	0.554
ACKR3	CCL19	A0A2U3Y5X3	A0A2U3Y6I7	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.515
ACKR3	CCL20	A0A2U3Y5X3	A0A2U3Z480	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.407
ACKR3	CCL21	A0A2U3Y5X3	A0A2U3Y6G1	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-C motif chemokine 21.	0.706
ACKR3	CCR7	A0A2U3Y5X3	A0A2U3YRB2	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.537
ACKR3	CXCL10	A0A2U3Y5X3	A0A2U3YK42	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.633
ACKR3	CXCL11	A0A2U3Y5X3	A0A2U3YKH5	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-X-C motif chemokine 11.	0.916
ACKR3	CXCL12	A0A2U3Y5X3	A0A2U3X9U4	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family.	0.997
ACKR3	CXCL13	A0A2U3Y5X3	A0A2U3YIF7	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-X-C motif chemokine 13.	0.568
ACKR3	CXCL6	A0A2U3Y5X3	A0A2U3XEV9	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.547
ACKR3	CXCR5	A0A2U3Y5X3	A0A2U3YD64	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family.	0.542
ACKR3	DARC	A0A2U3Y5X3	A0A2U3YE57	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Duffy antigen/chemokine receptor isoform X1.	0.568
ACKR3	LOC102740920	A0A2U3Y5X3	A0A2U3YKC3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.480
ACKR3	LOC102747594	A0A2U3Y5X3	A0A2U3YFN5	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family.	0.965
ACKR3	PPBP	A0A2U3Y5X3	A0A2U3XEG4	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: platelet basic protein.	0.473
ACKR4	CCL1	A0A2U3XZR0	A0A2U3YDB1	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	c-C motif chemokine 1.	0.904
ACKR4	CCL13	A0A2U3XZR0	A0A2U3YD71	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.913
ACKR4	CCL14	A0A2U3XZR0	A0A2U3Z278	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	c-C motif chemokine 14.	0.537
ACKR4	CCL17	A0A2U3XZR0	A0A2U3YY27	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	c-C motif chemokine 17.	0.625
ACKR4	CCL19	A0A2U3XZR0	A0A2U3Y6I7	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.676