STRINGSTRING
CACNG5 CACNG5 CACNG1 CACNG1 CACNG4 CACNG4 SLC24A1 SLC24A1 ORAI3 ORAI3 GPR98 GPR98 CATSPER3 CATSPER3 TRPC1 TRPC1 ANXA2 ANXA2 MCUR1 MCUR1 CACNB2 CACNB2 SLC35G1 SLC35G1 TRPA1 TRPA1 F2R F2R TMEM37 TMEM37 FAM155B FAM155B PAWR PAWR LOC102745146 LOC102745146 GRIN2A GRIN2A SLC8A3 SLC8A3 HTR2B HTR2B OPRM1 OPRM1 TRPC4 TRPC4 ORAI2 ORAI2 LOC102741278 LOC102741278 SCN11A SCN11A TRPM8 TRPM8 TMEM38B TMEM38B TMC2 TMC2 LOC102729524 LOC102729524 LOC102739875 LOC102739875 LOC102745028 LOC102745028 LOC102733455 LOC102733455 LOC102746964 LOC102746964 P2RX7 P2RX7 LOC102727336 LOC102727336 CCR5 CCR5 LOC102746549 LOC102746549 DDIT3 DDIT3 LOC102731343 LOC102731343 TMEM38A TMEM38A FGF2 FGF2 TRPC6 TRPC6 ANXA6 ANXA6 ANO6 ANO6 SLC25A23 SLC25A23 LOC102746542 LOC102746542 ORAI1 ORAI1 LOC102748816 LOC102748816 LOC102735431 LOC102735431 CATSPER4 CATSPER4 PKD1L2 PKD1L2 CNR1 CNR1 LOC102742727 LOC102742727 ATP2A3 ATP2A3 TRPV3 TRPV3 LOC102729478 LOC102729478 LOC102732520 LOC102732520 CACNG2 CACNG2 GRIN2D GRIN2D ATP2C1 ATP2C1 FKBP1B FKBP1B LOC102735415 LOC102735415 SLC25A25 SLC25A25 ITPR3 ITPR3 TRPV6 TRPV6 CACNB1 CACNB1 LOC102727240 LOC102727240 STIM2 STIM2 CACNB3 CACNB3 HTR2A HTR2A CACNA2D4 CACNA2D4 TRPV4 TRPV4 ITPR1 ITPR1 LOC102728759 LOC102728759 LOC102731583 LOC102731583 NOL3 NOL3 PANX1 PANX1 SLC24A4 SLC24A4 XCR1 XCR1 TRPM7 TRPM7 MCOLN3 MCOLN3 CACNA1G CACNA1G TRPC3 TRPC3 ATP2C2 ATP2C2 CALHM1 CALHM1 CCL19 CCL19 CCL21 CCL21 STOML2 STOML2 GAS6 GAS6 CACNA1F CACNA1F LOC102744643 LOC102744643 BAK1 BAK1 ITPR2 ITPR2 FASLG FASLG PKD2L2 PKD2L2 CACNG6 CACNG6 ANXA9 ANXA9 SLC8A1 SLC8A1 MICU2 MICU2 GRIN3A GRIN3A CCDC109B CCDC109B CACNA2D1 CACNA2D1 PKD2 PKD2 LRRIQ1 LRRIQ1 CACNG7 CACNG7 P2RX4 P2RX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
SLC24A1Sodium/potassium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1109 aa)
ORAI3Protein orai-3. (296 aa)
GPR98G-protein coupled receptor 98-like; Belongs to the G-protein coupled receptor 2 family. (6261 aa)
CATSPER3Cation channel sperm-associated protein 3. (415 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
ANXA2Annexin. (339 aa)
MCUR1Mitochondrial calcium uniporter regulator 1. (172 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (613 aa)
SLC35G1Solute carrier family 35 member G1 isoform X1. (365 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1120 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TMEM37Voltage-dependent calcium channel gamma-like subunit. (197 aa)
FAM155BTransmembrane protein FAM155B. (472 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1308 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
HTR2B5-hydroxytryptamine receptor 2B. (526 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (403 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
ORAI2Protein orai-2 isoform X1. (254 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1147 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
TMC2Transmembrane channel-like protein 2. (414 aa)
LOC102729524Transient receptor potential cation channel subfamily M member 7-like. (129 aa)
LOC102739875Plasma membrane calcium-transporting ATPase 3-like. (115 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102733455Sodium/potassium/calcium exchanger 3-like; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (269 aa)
LOC102746964Sodium/potassium/calcium exchanger 6, mitochondrial-like. (200 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
LOC102727336Voltage-dependent calcium channel subunit alpha-2/delta-3-like. (239 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC102746549Glutamate receptor ionotropic, NMDA 2C-like. (348 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC102731343Calcium homeostasis endoplasmic reticulum protein-like. (455 aa)
TMEM38ATrimeric intracellular cation channel type A. (252 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
TRPC6Short transient receptor potential channel 6-like isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
ANXA6Annexin. (673 aa)
ANO6Anoctamin. (800 aa)
SLC25A23Calcium-binding mitochondrial carrier protein SCaMC-3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
LOC102746542Transient receptor potential cation channel subfamily M member 2-like. (677 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
LOC102735431C-C motif chemokine. (93 aa)
CATSPER4Cation channel sperm-associated protein 4. (337 aa)
PKD1L2LOW QUALITY PROTEIN: polycystic kidney disease protein 1-like 2. (2241 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
LOC102742727Transient receptor potential cation channel subfamily V member 1-like. (267 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (605 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
LOC102732520Calcium-transporting ATPase type 2C member 1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (395 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (252 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (840 aa)
ATP2C1Calcium-transporting ATPase type 2C member 1-like isoform X1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (563 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
SLC25A25Calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (501 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (724 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (643 aa)
LOC102727240Uncharacterized protein C2orf47 homolog, mitochondrial. (288 aa)
STIM2Stromal interaction molecule 2-like. (794 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
HTR2A5-hydroxytryptamine receptor 2A. (263 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1102 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
LOC102728759Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (188 aa)
LOC102731583Voltage-dependent calcium channel gamma-3 subunit-like. (315 aa)
NOL3Nucleolar protein 3. (212 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
SLC24A4Sodium/potassium/calcium exchanger 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (513 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (331 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1731 aa)
MCOLN3Mucolipin-3 isoform X1. (553 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
TRPC3Short transient receptor potential channel 3-like. (592 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
CALHM1Calcium homeostasis modulator protein 1. (357 aa)
CCL19C-C motif chemokine. (100 aa)
CCL21c-C motif chemokine 21. (137 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
LOC102744643Short transient receptor potential channel 3-like. (453 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
PKD2L2Polycystic kidney disease 2-like 2 protein. (611 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
ANXA9Annexin. (345 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
MICU2Calcium uptake protein 2, mitochondrial isoform X1. (433 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A. (1115 aa)
CCDC109BMitochondrial calcium uniporter regulatory subunit MCUb. (84 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1091 aa)
PKD2Polycystin-2. (935 aa)
LRRIQ1Leucine-rich repeat and IQ domain-containing protein 1. (1644 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.