STRINGSTRING
LEP LEP IL34 IL34 LOC102734445 LOC102734445 NCK2 NCK2 CRTAM CRTAM LGALS9 LGALS9 TNFSF9 TNFSF9 LOC102745732 LOC102745732 LOC102740547 LOC102740547 LOC102731636 LOC102731636 LOC102740348 LOC102740348 PLA2G2F PLA2G2F NF1 NF1 MYD88 MYD88 IGF2 IGF2 STAT5A STAT5A TWF2 TWF2 MAPK8IP1 MAPK8IP1 IL4I1 IL4I1 CDKN1A CDKN1A CSF2 CSF2 LOC102748833 LOC102748833 LOC102738176 LOC102738176 SLC7A1 SLC7A1 SHH SHH LOC102742177 LOC102742177 LOC102731864 LOC102731864 HHLA2 HHLA2 NMB NMB TWSG1 TWSG1 RAC2 RAC2 CSF2RB CSF2RB PRKAR1A PRKAR1A BST1 BST1 TFRC TFRC CSF1R CSF1R IL12B IL12B LOC102739213 LOC102739213 CD74 CD74 IL23A IL23A LOC102739819 LOC102739819 SIGLEC10 SIGLEC10 NDFIP1 NDFIP1 KITLG KITLG ARG2 ARG2 STAT5B STAT5B AIF1 AIF1 IL21 IL21 IL2 IL2 LOC102750166 LOC102750166 PKN1 PKN1 BTK BTK PDCD1LG2 PDCD1LG2 BCL6 BCL6 LOC102738400 LOC102738400 FADD FADD KIAA0922 KIAA0922 VAV3 VAV3 TRAF6 TRAF6 LGALS3 LGALS3 AGER AGER BTNL2 BTNL2 LOC102745567 LOC102745567 SASH3 SASH3 MARCH7 MARCH7 PAWR PAWR TNFSF4 TNFSF4 LOC102741183 LOC102741183 PRKCQ PRKCQ IRF1 IRF1 DLG2 DLG2 IL10 IL10 ZP3 ZP3 CORO1A CORO1A HHEX HHEX CD320 CD320 CLEC4G CLEC4G IL18 IL18 VSIG4 VSIG4 ZP4 ZP4 PTEN PTEN IDO1 IDO1 CEBPB CEBPB IGF1 IGF1 MZB1 MZB1 CD22 CD22 LOC102749335 LOC102749335 CD80 CD80 DHPS DHPS GREM1 GREM1 SH3RF1 SH3RF1 CARD11 CARD11 PYCARD PYCARD BMI1 BMI1 FGF10 FGF10 AHR AHR GPNMB GPNMB NMBR NMBR GLMN GLMN NCKAP1L NCKAP1L PTPN22 PTPN22 RASSF5 RASSF5 CBLB CBLB LRRC1 LRRC1 CD300A CD300A FOXJ1 FOXJ1 NCK1 NCK1 TNFRSF21 TNFRSF21 IL7 IL7 TMEM147 TMEM147 TYROBP TYROBP LOC102743741 LOC102743741 FOXP3 FOXP3 LOC102726821 LOC102726821 SLAMF1 SLAMF1 MAPK1 MAPK1 CLCF1 CLCF1 ATM ATM PRNP PRNP MEF2C MEF2C CD40LG CD40LG BLK BLK CCDC88B CCDC88B PTH PTH CSF1 CSF1 LOC102725943 LOC102725943 TNFRSF14 TNFRSF14 TYK2 TYK2 LRRC32 LRRC32 LOC102727257 LOC102727257 CD28 CD28 CTLA4 CTLA4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
IL34Interleukin-34. (236 aa)
LOC102734445Phospholipase A(2). (145 aa)
NCK2Cytoplasmic protein. (380 aa)
CRTAMCytotoxic and regulatory T-cell molecule. (366 aa)
LGALS9Galectin. (364 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (177 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102731636Zinc finger protein Aiolos-like isoform X1. (262 aa)
LOC102740348Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
PLA2G2FPhospholipase A(2). (210 aa)
NF1Neurofibromin-like. (1269 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IGF2Insulin-like growth factor II. (138 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
MAPK8IP1c-Jun-amino-terminal kinase-interacting protein 1. (669 aa)
IL4I1L-amino-acid oxidase. (386 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102738176Spectrin alpha chain, erythrocytic 1-like. (1276 aa)
SLC7A1High affinity cationic amino acid transporter 1. (229 aa)
SHHSonic hedgehog protein-like. (286 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
HHLA2LOW QUALITY PROTEIN: HERV-H LTR-associating 2. (282 aa)
NMBneuromedin-B isoform X2. (153 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
BST1ADP-ribosyl cyclase 2. (312 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
LOC102739819Spectrin alpha chain, erythrocytic 1-like. (1472 aa)
SIGLEC10Sialic acid-binding Ig-like lectin 10. (692 aa)
NDFIP1NEDD4 family-interacting protein 1 isoform X1. (221 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ARG2Arginase. (354 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
PKN1Serine/threonine-protein kinase N1. (796 aa)
BTKTyrosine-protein kinase. (659 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
LOC102738400Annexin. (345 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
KIAA0922Transmembrane protein 131-like. (1601 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LGALS3Galectin. (285 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
BTNL2Butyrophilin-like protein 2. (455 aa)
LOC102745567Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (309 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7. (695 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
LOC102741183Roquin-1-like. (688 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IRF1Interferon regulatory factor. (322 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
IL10Interleukin-10. (178 aa)
ZP3Zona pellucida sperm-binding protein 3. (427 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (270 aa)
CD320CD320 antigen. (258 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4 isoform X1. (399 aa)
ZP4Zona pellucida sperm-binding protein 4 isoform X1. (574 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (394 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
MZB1Marginal zone B- and B1-cell-specific protein. (189 aa)
CD22B-cell receptor CD22 isoform X1. (844 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
CD80LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
GREM1Gremlin. (184 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (872 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
AHRAryl hydrocarbon receptor. (843 aa)
GPNMBTransmembrane glycoprotein NMB isoform X2. (554 aa)
NMBRneuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (402 aa)
GLMNGlomulin. (521 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (805 aa)
RASSF5Ras association domain-containing protein 5. (194 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
CD300ACMRF35-like molecule 8. (309 aa)
FOXJ1Forkhead box protein J1. (421 aa)
NCK1Cytoplasmic protein. (377 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X1. (651 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
TMEM147Transmembrane protein 147 isoform X1. (224 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (111 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
LOC102726821Galectin. (139 aa)
SLAMF1Signaling lymphocytic activation molecule. (312 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
BLKTyrosine-protein kinase. (500 aa)
CCDC88BCoiled-coil domain-containing protein 88B. (1465 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14. (272 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
LRRC32Leucine-rich repeat-containing protein 32. (663 aa)
LOC102727257Tumor necrosis factor receptor superfamily member 13B-like. (270 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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