STRINGSTRING
VIL1 VIL1 LOC102744304 LOC102744304 CLDN5 CLDN5 LOC102743697 LOC102743697 LOC102730129 LOC102730129 LOC102731864 LOC102731864 LOC102726881 LOC102726881 LOC102744413 LOC102744413 EMD EMD LOC102736146 LOC102736146 LOC102731352 LOC102731352 LOC102735151 LOC102735151 AKT1S1 AKT1S1 LOC102750604 LOC102750604 LOC102739274 LOC102739274 ZCCHC18 ZCCHC18 LOC102740569 LOC102740569 LOC102744822 LOC102744822 FGF22 FGF22 ADAMTS12 ADAMTS12 CILP CILP RUNX3 RUNX3 LOC102741867 LOC102741867 STAT3 STAT3 DDIT3 DDIT3 MARS MARS SHCBP1 SHCBP1 MTMR4 MTMR4 NTF4 NTF4 BMP2 BMP2 RAMP2 RAMP2 FGF2 FGF2 LOC102745745 LOC102745745 LOC102730108 LOC102730108 LOC102742360 LOC102742360 LOC102730318 LOC102730318 LOC102738856 LOC102738856 FGF23 FGF23 FGF6 FGF6 LOC102740057 LOC102740057 LOC102750017 LOC102750017 LOC102740157 LOC102740157 LOC102727681 LOC102727681 LOC102743250 LOC102743250 LOC102740547 LOC102740547 LOC102743045 LOC102743045 LOC102749531 LOC102749531 CITED2 CITED2 ABL1 ABL1 NTRK1 NTRK1 LOC102750402 LOC102750402 GDF1 GDF1 COMP COMP MEGF8 MEGF8 NOTCH2 NOTCH2 ZYX ZYX TGFB3 TGFB3 TGFB1 TGFB1 FGF21 FGF21 PDGFRA PDGFRA HFE2 HFE2 LOC102735329 LOC102735329 NDNF NDNF MED1 MED1 LOC102737030 LOC102737030 GDF5 GDF5 TMEM108 TMEM108 FGFRL1 FGFRL1 SFRP1 SFRP1 LRRC32 LRRC32 CLEC3B CLEC3B MAP2K3 MAP2K3 GNB2L1 GNB2L1 GDF15 GDF15 VEGFB VEGFB FOXH1 FOXH1 LOC102737831 LOC102737831 PIK3CA PIK3CA LOC102733219 LOC102733219 PGF PGF FOS FOS NODAL NODAL PIK3CD PIK3CD BMP6 BMP6 LTBP4 LTBP4 FGF18 FGF18 FGF4 FGF4 SEMA6A SEMA6A FGF3 FGF3 LOC102737823 LOC102737823 LOC102727345 LOC102727345 KIDINS220 KIDINS220 MEF2C MEF2C FGF17 FGF17 CRKL CRKL FLCN FLCN GLG1 GLG1 LOC102747801 LOC102747801 SMAD1 SMAD1 GAREM GAREM MSX1 MSX1 LOC102728858 LOC102728858 CORO1B CORO1B MAPK1 MAPK1 ZFP36 ZFP36 ACVRL1 ACVRL1 ZNF259 ZNF259 CXCL13 CXCL13 LOC102744866 LOC102744866 WNT10A WNT10A ETV2 ETV2 BMP7 BMP7 ZFP36L2 ZFP36L2 DLL4 DLL4 KNSTRN KNSTRN TWSG1 TWSG1 LOC102745999 LOC102745999 LEFTY1 LEFTY1 ATF2 ATF2 AMHR2 AMHR2 NRROS NRROS MYO1C MYO1C BAG4 BAG4 INPP5K INPP5K LOC102749080 LOC102749080 GATA3 GATA3 EGR3 EGR3 VILL VILL PML PML PHOX2B PHOX2B WFIKKN2 WFIKKN2 CITED1 CITED1 USP15 USP15 DSG4 DSG4 BMPR1A BMPR1A RPS6KB1 RPS6KB1 RAF1 RAF1 LTBP3 LTBP3 FIBP FIBP VEGFC VEGFC RAPGEF2 RAPGEF2 CTGF CTGF KDM5B KDM5B LOC102741200 LOC102741200 JUN JUN ZFP36L1 ZFP36L1 SIRT2 SIRT2 HAS2 HAS2 LOC102741496 LOC102741496 RGMA RGMA NTRK2 NTRK2 NGF NGF FST FST LOC102740904 LOC102740904 TP53 TP53 PDCD5 PDCD5 FGFR2 FGFR2 SOST SOST LOC102730764 LOC102730764 CHURC1 CHURC1 GAS6 GAS6 STAT5B STAT5B LOC102745161 LOC102745161 NKPD1 NKPD1 NANOG NANOG ZFYVE27 ZFYVE27 TGFB2 TGFB2 GDF3 GDF3 ANKRD1 ANKRD1 BMP8B BMP8B ITGB1BP1 ITGB1BP1 FGF5 FGF5 LOC102745156 LOC102745156 EGR1 EGR1 ONECUT2 ONECUT2 LOC102738400 LOC102738400 LOC102728321 LOC102728321 FGFR3 FGFR3 LOC102726900 LOC102726900 CEP57 CEP57 LOC102732879 LOC102732879 RAB14 RAB14 LOC102747185 LOC102747185 SOSTDC1 SOSTDC1 ZCCHC12 ZCCHC12 NTF3 NTF3 HIPK2 HIPK2 PTPN11 PTPN11 TRIM71 TRIM71 FGF7 FGF7 FERMT2 FERMT2 FLRT3 FLRT3 CCDC142 CCDC142 HTRA2 HTRA2 ZMIZ1 ZMIZ1 GAB1 GAB1 ACVR1 ACVR1 ACVR1C ACVR1C SHC1 SHC1 SMAD4 SMAD4 LOC102733670 LOC102733670 BMPR2 BMPR2 NUS1 NUS1 DDR2 DDR2 ITGB3 ITGB3 IL10 IL10 SMAD9 SMAD9 CORO1A CORO1A TGFBR2 TGFBR2 HSPB1 HSPB1 LOC102748159 LOC102748159 TGFBR3L TGFBR3L SRC SRC BMPR1B BMPR1B ACVR2B ACVR2B CREB1 CREB1 LOC102736562 LOC102736562 FGF12 FGF12 FGFR4 FGFR4 LOC102734862 LOC102734862 GATA6 GATA6 TBC1D7 TBC1D7 LOC102725595 LOC102725595 KLB KLB PTPN12 PTPN12 MAPK7 MAPK7 PRDM14 PRDM14 DLX1 DLX1 NLK NLK SPG20 SPG20 DDIT4 DDIT4 FGF8 FGF8 TPR TPR LOC102734040 LOC102734040 COL1A2 COL1A2 PDE2A PDE2A SMPD3 SMPD3 NOG NOG TMEM100 TMEM100 VSTM2A VSTM2A IL8 IL8 FGF10 FGF10 LOC102745004 LOC102745004 WASF1 WASF1 LOC102747536 LOC102747536 HPGD HPGD SLC33A1 SLC33A1 FRS3 FRS3 COL2A1 COL2A1 CAV1 CAV1 KL KL BMPER BMPER EEF1A1 EEF1A1 LPXN LPXN BMP5 BMP5 SOX5 SOX5 FGF9 FGF9 RGMB RGMB ACVR2A ACVR2A SNAI2 SNAI2 PDGFRL PDGFRL FGF20 FGF20 SFRP2 SFRP2 LEF1 LEF1 HGF HGF IBSP IBSP MSTN MSTN FGF16 FGF16 LOC102740025 LOC102740025
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VIL1Villin-1. (330 aa)
LOC102744304EP300-interacting inhibitor of differentiation 2-like. (122 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
LOC102743697Probable ubiquitin carboxyl-terminal hydrolase FAF-X-like. (164 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
LOC102744413Left-right determination factor 2-like. (165 aa)
EMDEmerin. (260 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
LOC102750604E3 ubiquitin-protein ligase TRIM71-like. (536 aa)
LOC102739274Zinc finger protein 8-like. (479 aa)
ZCCHC18Putative zinc finger CCHC domain-containing protein 18. (403 aa)
LOC102740569Transmembrane protease serine 6-like. (215 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
ADAMTS12A disintegrin and metalloproteinase with thrombospondin motifs 12-like. (1047 aa)
CILPLOW QUALITY PROTEIN: cartilage intermediate layer protein 1. (1160 aa)
RUNX3Runt-related transcription factor 3-like. (283 aa)
LOC102741867Villin-1-like. (505 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
MARSmethionine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa)
SHCBP1SHC SH2 domain-binding protein 1. (324 aa)
MTMR4Myotubularin-related protein 4-like. (585 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
RAMP2Receptor activity-modifying protein 2. (118 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102745745Tyrosine-protein kinase receptor. (302 aa)
LOC102730108Neuropilin-1-like. (465 aa)
LOC102742360A disintegrin and metalloproteinase with thrombospondin motifs 7-like. (718 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102738856Villin-like protein-like. (205 aa)
FGF23Fibroblast growth factor 23. (177 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC102750017Mothers against decapentaplegic homolog 6-like. (181 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
LOC102727681Exostosin-2-like. (142 aa)
LOC102743250Transcription factor GATA-5-like. (300 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
LOC102750402E3 ubiquitin-protein ligase SMURF1-like. (321 aa)
GDF1Embryonic growth/differentiation factor 1. (227 aa)
COMPCartilage oligomeric matrix protein. (728 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2068 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
ZYXZyxin. (579 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
HFE2Hemojuvelin-like isoform X1. (428 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
NDNFProtein NDNF. (568 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
GDF5Growth/differentiation factor 5. (499 aa)
TMEM108Transmembrane protein 108. (581 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (508 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
LRRC32Leucine-rich repeat-containing protein 32. (663 aa)
CLEC3BTetranectin isoform X1. (202 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
GDF15Growth/differentiation factor 15. (308 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FOXH1Forkhead box protein H1. (360 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102733219Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
NODALNodal homolog. (348 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1519 aa)
FGF18Fibroblast growth factor 18. (116 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X2. (1753 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CRKLCrk-like protein. (303 aa)
FLCNFolliculin. (579 aa)
GLG1LOW QUALITY PROTEIN: Golgi apparatus protein 1. (641 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GAREMGRB2-associated and regulator of MAPK protein. (753 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LOC102728858Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family. (251 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (489 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ZFP36Tristetraprolin. (325 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ZNF259Zinc finger protein ZPR1. (460 aa)
CXCL13c-X-C motif chemokine 13. (110 aa)
LOC102744866GDNF family receptor alpha; Belongs to the GDNFR family. (462 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
ETV2ETS translocation variant 2 isoform X1. (340 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
ZFP36L2Zinc finger protein 36, C3H1 type-like 2-like. (491 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
KNSTRNSmall kinetochore-associated protein isoform X1. (316 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
LOC102745999Left-right determination factor 1-like. (203 aa)
LEFTY1Left-right determination factor. (366 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
BAG4BAG family molecular chaperone regulator 4. (421 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
LOC102749080Mothers against decapentaplegic homolog 5-like. (245 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
VILLVillin-like protein-like. (375 aa)
PMLProtein PML. (880 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (573 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
DSG4Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1043 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
FIBPAcidic fibroblast growth factor intracellular-binding protein isoform X1. (364 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1499 aa)
CTGFConnective tissue growth factor. (211 aa)
KDM5BLysine-specific demethylase 5B. (872 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1 isoform X1. (338 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
HAS2Hyaluronan synthase 2-like. (552 aa)
LOC102741496BDNF/NT-3 growth factors receptor-like. (97 aa)
RGMARepulsive guidance molecule A. (346 aa)
NTRK2BDNF/NT-3 growth factors receptor-like. (420 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
FSTFollistatin isoform X1. (344 aa)
LOC102740904Unconventional prefoldin RPB5 interactor-like. (458 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PDCD5Programmed cell death protein 5. (125 aa)
FGFR2Fibroblast growth factor receptor 2. (658 aa)
SOSTSclerostin. (213 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
CHURC1Protein Churchill isoform X1. (139 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1. (822 aa)
NANOGHomeobox protein NANOG. (226 aa)
ZFYVE27Protrudin. (411 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GDF3Growth/differentiation factor 3. (365 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
BMP8BBone morphogenetic protein 8B. (169 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
ONECUT2One cut domain family member. (430 aa)
LOC102738400Annexin. (345 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
CEP57Centrosomal protein of 57 kDa isoform X1. (500 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
RAB14Ras-related protein Rab-14. (215 aa)
LOC102747185Homeobox protein DLX-5-like. (214 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
ZCCHC12Zinc finger CCHC domain-containing protein 12. (402 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (369 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FERMT2Fermitin family homolog 2 isoform X1. (687 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3 isoform X1. (649 aa)
CCDC142Coiled-coil domain-containing protein 142. (766 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform X1. (458 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (957 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC102733670Probable helicase senataxin-like. (227 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
NUS1nogo-B receptor-like. (293 aa)
DDR2Discoidin domain-containing receptor 2-like. (367 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
IL10Interleukin-10. (178 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
LOC102748159Leucine-rich repeat transmembrane protein FLRT2-like. (660 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (292 aa)
SRCTyrosine-protein kinase. (536 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (434 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC102736562A disintegrin and metalloproteinase with thrombospondin motifs 12-like. (115 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GATA6Transcription factor GATA-6. (287 aa)
TBC1D7TBC1 domain family member 7 isoform X1. (293 aa)
LOC102725595Fibroblast growth factor receptor substrate 2-like. (316 aa)
KLBBeta-klotho. (1037 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12 isoform X3. (782 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
SPG20Spartin isoform X1. (691 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
TPRNucleoprotein TPR-like isoform X1. (2439 aa)
LOC102734040Zinc finger FYVE domain-containing protein 9-like. (577 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
PDE2APhosphodiesterase. (943 aa)
SMPD3Sphingomyelin phosphodiesterase 3 isoform X1. (653 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMEM100Transmembrane protein 100. (134 aa)
VSTM2AV-set and transmembrane domain-containing protein 2A. (236 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
LOC102745004SHC SH2 domain-binding protein 1-like. (497 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
LOC102747536Necdin-like. (325 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SLC33A1Acetyl-coenzyme A transporter 1. (549 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
KLKlotho. (1081 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
SOX5Transcription factor SOX-5 isoform X2. (763 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RGMBRGM domain family member B. (482 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
PDGFRLPlatelet-derived growth factor receptor-like protein. (387 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
IBSPBone sialoprotein 2. (318 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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