(35 nodes) Cellular response to amino acid stimulus network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RRAGC	Ras-related GTP-binding protein C isoform X1. (399 aa)
	SESN2	Sestrin-2. (481 aa)
	GATSL3	GATS-like protein 3. (329 aa)
	NEURL1	Neuralized-like protein 1A. (574 aa)
	LOC102741496	BDNF/NT-3 growth factors receptor-like. (97 aa)
	NTRK2	BDNF/NT-3 growth factors receptor-like. (420 aa)
	AMIGO2	Amphoterin-induced protein 2. (521 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2 isoform X1. (125 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3. (111 aa)
	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B isoform X1. (259 aa)
	LOC102732272	Ragulator complex protein LAMTOR1-like. (152 aa)
	IPO5	Importin-5 isoform X1. (1097 aa)
	CPEB3	Cytoplasmic polyadenylation element-binding protein 3. (704 aa)
	LAMTOR4	Ragulator complex protein LAMTOR4. (99 aa)
	RRAGD	Ras-related GTP-binding protein D. (396 aa)
	RRAGB	Ras-related GTP-binding protein B isoform X1. (374 aa)
	LARS	leucine--tRNA ligase, cytoplasmic isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa)
	DNMT3A	DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (835 aa)
	LAMTOR5	Ragulator complex protein LAMTOR5. (91 aa)
	CEBPB	CCAAT/enhancer-binding protein. (345 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1753 aa)
	COL1A2	Collagen alpha-2(I) chain. (1365 aa)
	SESN1	Sestrin-1 isoform X1. (551 aa)
	LOC102742552	Platelet-derived growth factor D-like isoform X1. (370 aa)
	PDGFC	Platelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	CAPN8	LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
	LOC102740078	Ragulator complex protein LAMTOR1-like. (98 aa)
	GLRA4	Glycine receptor subunit alpha-4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1613 aa)
	COL6A1	Collagen alpha-1(VI) chain. (1027 aa)
	SESN3	Sestrin-3 isoform X1. (492 aa)
	RRAGA	Ras-related GTP-binding protein A. (313 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEBPB	TNF	A0A2U3XKB7	A0A2U3Y499	CCAAT/enhancer-binding protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.528
COL1A2	COL6A1	A0A2U3XGW4	A0A2U3YQN6	Collagen alpha-2(I) chain.	Collagen alpha-1(VI) chain.	0.968
COL1A2	PDGFRA	A0A2U3XGW4	A0A2U3YV07	Collagen alpha-2(I) chain.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.499
COL6A1	COL1A2	A0A2U3YQN6	A0A2U3XGW4	Collagen alpha-1(VI) chain.	Collagen alpha-2(I) chain.	0.968
DNMT1	DNMT3A	A0A2U3YSF5	A0A2U3XNL4	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.987
DNMT3A	DNMT1	A0A2U3XNL4	A0A2U3YSF5	DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.987
GATSL3	SESN1	A0A2U3Y7M2	A0A2U3XDH2	GATS-like protein 3.	Sestrin-1 isoform X1.	0.497
GATSL3	SESN2	A0A2U3Y7M2	A0A2U3Y886	GATS-like protein 3.	Sestrin-2.	0.659
LAMTOR2	LAMTOR3	A0A2U3XZ78	A0A2U3XUR6	Ragulator complex protein LAMTOR2 isoform X1.	Ragulator complex protein LAMTOR3.	0.999
LAMTOR2	LAMTOR4	A0A2U3XZ78	A0A2U3XQU2	Ragulator complex protein LAMTOR2 isoform X1.	Ragulator complex protein LAMTOR4.	0.999
LAMTOR2	LAMTOR5	A0A2U3XZ78	A0A2U3XN45	Ragulator complex protein LAMTOR2 isoform X1.	Ragulator complex protein LAMTOR5.	0.999
LAMTOR2	LOC102732272	A0A2U3XZ78	A0A2U3XSV4	Ragulator complex protein LAMTOR2 isoform X1.	Ragulator complex protein LAMTOR1-like.	0.992
LAMTOR2	LOC102740078	A0A2U3XZ78	A0A2U3Z7C8	Ragulator complex protein LAMTOR2 isoform X1.	Ragulator complex protein LAMTOR1-like.	0.992
LAMTOR2	MTOR	A0A2U3XZ78	A0A2U3XVT2	Ragulator complex protein LAMTOR2 isoform X1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.952
LAMTOR2	RRAGA	A0A2U3XZ78	A0A2U3YDU5	Ragulator complex protein LAMTOR2 isoform X1.	Ras-related GTP-binding protein A.	0.956
LAMTOR2	RRAGB	A0A2U3XZ78	A0A2U3XQB1	Ragulator complex protein LAMTOR2 isoform X1.	Ras-related GTP-binding protein B isoform X1.	0.956
LAMTOR2	RRAGC	A0A2U3XZ78	A0A2U3YFX9	Ragulator complex protein LAMTOR2 isoform X1.	Ras-related GTP-binding protein C isoform X1.	0.996
LAMTOR2	RRAGD	A0A2U3XZ78	A0A2U3XQM8	Ragulator complex protein LAMTOR2 isoform X1.	Ras-related GTP-binding protein D.	0.954
LAMTOR2	SESN1	A0A2U3XZ78	A0A2U3XDH2	Ragulator complex protein LAMTOR2 isoform X1.	Sestrin-1 isoform X1.	0.556
LAMTOR2	SESN2	A0A2U3XZ78	A0A2U3Y886	Ragulator complex protein LAMTOR2 isoform X1.	Sestrin-2.	0.556