STRINGSTRING
PKD2 PKD2 CFTR CFTR AHR AHR PDE2A PDE2A HCN4 HCN4 HCN3 HCN3 CRHBP CRHBP AQP9 AQP9 KCNQ1 KCNQ1 ZFP36L1 ZFP36L1 RAPGEF2 RAPGEF2 RAP1B RAP1B HCN2 HCN2 INPP5K INPP5K KCNE1 KCNE1 DMTN DMTN IGFBP5 IGFBP5 LOC102749897 LOC102749897 AQP1 AQP1 WT1 WT1 GPD1 GPD1 WNT10B WNT10B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKD2Polycystin-2. (935 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
AHRAryl hydrocarbon receptor. (843 aa)
PDE2APhosphodiesterase. (943 aa)
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (1039 aa)
HCN3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3. (782 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
AQP9Aquaporin-9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1 isoform X1. (338 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1499 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
HCN2Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. (597 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1 isoform X2. (124 aa)
DMTNDematin isoform X1. (405 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)
LOC102749897A-kinase anchor protein 7 isoforms alpha and beta-like. (104 aa)
AQP1Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
WT1Wilms tumor protein-like. (413 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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