STRINGSTRING
DLG2 DLG2 NPHS2 NPHS2 PTPRO PTPRO ILK ILK LHX1 LHX1 IRX3 IRX3 HOXA11 HOXA11 LOC102731342 LOC102731342 GREM1 GREM1 SIX1 SIX1 NOG NOG CALB1 CALB1 WNT1 WNT1 BMPER BMPER GDF11 GDF11 RET RET FOXJ1 FOXJ1 LGR4 LGR4 PKD2 PKD2 GZF1 GZF1 LOC102745028 LOC102745028 LOC102735151 LOC102735151 LOC102744822 LOC102744822 FGF2 FGF2 BMP2 BMP2 LOC102726488 LOC102726488 LOC102731463 LOC102731463 SMAD1 SMAD1 KANK2 KANK2 CER1 CER1 DLL1 DLL1 COMMD5 COMMD5 MEF2C MEF2C LOC102727345 LOC102727345 CTNNBIP1 CTNNBIP1 KIF26B KIF26B SALL1 SALL1 LOC102729478 LOC102729478 SFRP1 SFRP1 TMEM59L TMEM59L CRLF1 CRLF1 AQP1 AQP1 NOTCH2 NOTCH2 LOC102740547 LOC102740547 WT1 WT1 LOC102750017 LOC102750017 LOC102737253 LOC102737253 LOC102730318 LOC102730318 LAMB2 LAMB2 WNT9B WNT9B EYA1 EYA1 EPHA4 EPHA4 WNT11 WNT11 WNT6 WNT6 NPHS1 NPHS1 LOC102746898 LOC102746898 BMP7 BMP7 MTSS1 MTSS1 SPRY1 SPRY1 GATA3 GATA3 LOC102737096 LOC102737096 TCF21 TCF21 LOC102741200 LOC102741200 AQP11 AQP11 TACSTD2 TACSTD2 HS2ST1 HS2ST1 SOX8 SOX8 IRX1 IRX1 ARG2 ARG2 PTCH1 PTCH1 JAG1 JAG1 SIX2 SIX2 LOC102726900 LOC102726900 RARB RARB OSR1 OSR1 SMAD4 SMAD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLG2Disks large homolog 2 isoform X1. (905 aa)
NPHS2Podocin. (377 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (538 aa)
HOXA11Homeobox protein Hox-A11. (321 aa)
LOC102731342Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
GREM1Gremlin. (184 aa)
SIX1Homeobox protein SIX1. (284 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CALB1Calbindin. (261 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
GDF11Growth/differentiation factor 11. (372 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
FOXJ1Forkhead box protein J1. (421 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
PKD2Polycystin-2. (935 aa)
GZF1GDNF-inducible zinc finger protein 1. (719 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102726488Iroquois-class homeodomain protein IRX-2-like. (414 aa)
LOC102731463Transcription factor AP-2-beta-like. (180 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (419 aa)
CER1Cerberus. (274 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
COMMD5COMM domain-containing protein 5. (224 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
KIF26BKinesin-like protein KIF26B-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa)
SALL1Sal-like protein 1-like. (1314 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
TMEM59LTransmembrane protein 59-like. (350 aa)
CRLF1Cytokine receptor-like factor 1. (527 aa)
AQP1Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
WT1Wilms tumor protein-like. (413 aa)
LOC102750017Mothers against decapentaplegic homolog 6-like. (181 aa)
LOC102737253Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
NPHS1Nephrin. (1242 aa)
LOC102746898Protein GREB1-like. (1593 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
MTSS1Metastasis suppressor protein 1 isoform X3. (529 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LOC102737096Retinoic acid receptor beta-like. (262 aa)
TCF21Transcription factor 21. (179 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (302 aa)
SOX8Transcription factor SOX-8. (412 aa)
IRX1Iroquois-class homeodomain protein IRX-1-like. (391 aa)
ARG2Arginase. (354 aa)
PTCH1Protein patched homolog 1. (1301 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SIX2Homeobox protein SIX2. (294 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
RARBRetinoic acid receptor beta. (172 aa)
OSR1Protein odd-skipped-related 1 isoform X1. (267 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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