(13 nodes) Nephron tubule formation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (302 aa)
	LOC102737253	Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
	LOC102726488	Iroquois-class homeodomain protein IRX-2-like. (414 aa)
	SOX8	Transcription factor SOX-8. (412 aa)
	IRX1	Iroquois-class homeodomain protein IRX-1-like. (391 aa)
	OSR1	Protein odd-skipped-related 1 isoform X1. (267 aa)
	IRX3	Iroquois-class homeodomain protein IRX-3. (538 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	GREM1	Gremlin. (184 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRX1	LOC102726488	A0A2U3Y5N5	A0A2U3Z891	Iroquois-class homeodomain protein IRX-1-like.	Iroquois-class homeodomain protein IRX-2-like.	0.537
IRX1	LOC102727345	A0A2U3Y5N5	A0A2U3YND0	Iroquois-class homeodomain protein IRX-1-like.	Transcription factor SOX-9-like.	0.487
IRX3	LOC102726488	A0A2U3XMF0	A0A2U3Z891	Iroquois-class homeodomain protein IRX-3.	Iroquois-class homeodomain protein IRX-2-like.	0.535
LOC102726488	IRX1	A0A2U3Z891	A0A2U3Y5N5	Iroquois-class homeodomain protein IRX-2-like.	Iroquois-class homeodomain protein IRX-1-like.	0.537
LOC102726488	IRX3	A0A2U3Z891	A0A2U3XMF0	Iroquois-class homeodomain protein IRX-2-like.	Iroquois-class homeodomain protein IRX-3.	0.535
LOC102727345	IRX1	A0A2U3YND0	A0A2U3Y5N5	Transcription factor SOX-9-like.	Iroquois-class homeodomain protein IRX-1-like.	0.487
LOC102727345	NOG	A0A2U3YND0	A0A2U3XEL8	Transcription factor SOX-9-like.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.650
LOC102737253	NOG	A0A2U3Z218	A0A2U3XEL8	Glial cell line-derived neurotrophic factor-like isoform X1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.638
LOC102737253	WNT9B	A0A2U3Z218	A0A2U3YJ26	Glial cell line-derived neurotrophic factor-like isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.525
NOG	LOC102727345	A0A2U3XEL8	A0A2U3YND0	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Transcription factor SOX-9-like.	0.650
NOG	LOC102737253	A0A2U3XEL8	A0A2U3Z218	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Glial cell line-derived neurotrophic factor-like isoform X1.	0.638
WNT6	WNT9B	A0A2U3YGW7	A0A2U3YJ26	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.576
WNT9B	LOC102737253	A0A2U3YJ26	A0A2U3Z218	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Glial cell line-derived neurotrophic factor-like isoform X1.	0.525
WNT9B	WNT6	A0A2U3YJ26	A0A2U3YGW7	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.576