(43 nodes) Stem cell proliferation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC102750604	E3 ubiquitin-protein ligase TRIM71-like. (536 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CD109	CD109 antigen. (1322 aa)
	BRCA2	Breast cancer type 2 susceptibility protein homolog. (2818 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	OSR2	Protein odd-skipped-related 2 isoform X1. (312 aa)
	CDKN2C	Cyclin-dependent kinase 4 inhibitor C. (168 aa)
	HOXA3	Homeobox protein Hox-A3. (440 aa)
	HMX2	Homeobox protein HMX2. (273 aa)
	GBA	Glucosylceramidase. (536 aa)
	RNF43	E3 ubiquitin-protein ligase RNF43 isoform X1. (781 aa)
	TRIM71	E3 ubiquitin-protein ligase TRIM71. (369 aa)
	RARB	Retinoic acid receptor beta. (172 aa)
	PTCH1	Protein patched homolog 1. (1301 aa)
	CTC1	CST complex subunit CTC1. (1218 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (661 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	LOC102735189	Intraflagellar transport protein 20 homolog. (115 aa)
	HOXB4	Homeobox protein Hox-B4. (107 aa)
	TBX3	T-box transcription factor TBX3. (675 aa)
	LOC102739902	Uncharacterized protein C1orf172 homolog. (397 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
	OVOL1	Putative transcription factor Ovo-like 1. (267 aa)
	LIG4	DNA ligase. (911 aa)
	LOC102737096	Retinoic acid receptor beta-like. (262 aa)
	RARG	Retinoic acid receptor gamma isoform X1. (486 aa)
	CEP120	Centrosomal protein of 120 kDa. (910 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	LOC102749599	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	YAP1	Yorkie homolog. (326 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	BABAM1	BRISC and BRCA1-A complex member 1. (336 aa)
	NF1	Neurofibromin-like. (1269 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC102744116	Interferon regulatory factor 6-like. (227 aa)
	LOC102733867	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (385 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH2	NR2E1	A0A2U3Z5Z0	A0A2U3XDI7	RBR-type E3 ubiquitin transferase.	Nuclear receptor subfamily 2 group E member 1.	0.477
BABAM1	BRCA2	A0A2U3Z1D6	A0A2U3XC46	BRISC and BRCA1-A complex member 1.	Breast cancer type 2 susceptibility protein homolog.	0.414
BRCA2	BABAM1	A0A2U3XC46	A0A2U3Z1D6	Breast cancer type 2 susceptibility protein homolog.	BRISC and BRCA1-A complex member 1.	0.414
BRCA2	ERCC2	A0A2U3XC46	A0A2U3Y4Q8	Breast cancer type 2 susceptibility protein homolog.	TFIIH basal transcription factor complex helicase XPD subunit.	0.741
BRCA2	LIG4	A0A2U3XC46	A0A2U3YB17	Breast cancer type 2 susceptibility protein homolog.	DNA ligase.	0.622
BRCA2	LOC102733867	A0A2U3XC46	A0A2U3Z7B1	Breast cancer type 2 susceptibility protein homolog.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.414
BRCA2	NF1	A0A2U3XC46	A0A2U3Z255	Breast cancer type 2 susceptibility protein homolog.	Neurofibromin-like.	0.473
BRCA2	TP53	A0A2U3XC46	A0A2U3Y5G3	Breast cancer type 2 susceptibility protein homolog.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.879
CDKN2C	TP53	A0A2U3XKW5	A0A2U3Y5G3	Cyclin-dependent kinase 4 inhibitor C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.928
ERCC2	BRCA2	A0A2U3Y4Q8	A0A2U3XC46	TFIIH basal transcription factor complex helicase XPD subunit.	Breast cancer type 2 susceptibility protein homolog.	0.741
ERCC2	LIG4	A0A2U3Y4Q8	A0A2U3YB17	TFIIH basal transcription factor complex helicase XPD subunit.	DNA ligase.	0.753
FGF10	FGF2	A0A2U3XE64	A0A2U3Z312	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
FGF10	FGF4	A0A2U3XE64	A0A2U3YP27	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.525
FGF10	LOC102727345	A0A2U3XE64	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.509
FGF2	FGF10	A0A2U3Z312	A0A2U3XE64	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
FGF2	LOC102727345	A0A2U3Z312	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.582
FGF2	TP53	A0A2U3Z312	A0A2U3Y5G3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.443
FGF2	WNT1	A0A2U3Z312	A0A2U3XCV6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.453
FGF4	FGF10	A0A2U3YP27	A0A2U3XE64	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.525
FGF4	LOC102727345	A0A2U3YP27	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.488