(20 nodes) Metanephric nephron development network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102737253	Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
	LAMB2	Laminin subunit beta-2 isoform X1. (1801 aa)
	WT1	Wilms tumor protein-like. (413 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	AQP1	Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	SALL1	Sal-like protein 1-like. (1314 aa)
	LOC102726488	Iroquois-class homeodomain protein IRX-2-like. (414 aa)
	KIF26B	Kinesin-like protein KIF26B-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	TCF21	Transcription factor 21. (179 aa)
	SOX8	Transcription factor SOX-8. (412 aa)
	IRX1	Iroquois-class homeodomain protein IRX-1-like. (391 aa)
	OSR1	Protein odd-skipped-related 1 isoform X1. (267 aa)
	NPHS2	Podocin. (377 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	GREM1	Gremlin. (184 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	PKD2	Polycystin-2. (935 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP1	NPHS2	A0A2U3YWJ5	A0A2U3XS05	Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Podocin.	0.451
GREM1	LOC102740547	A0A2U3XFV2	A0A2U3Z034	Gremlin.	Bone morphogenetic protein 4-like isoform X1.	0.820
IRX1	LOC102726488	A0A2U3Y5N5	A0A2U3Z891	Iroquois-class homeodomain protein IRX-1-like.	Iroquois-class homeodomain protein IRX-2-like.	0.537
IRX1	LOC102727345	A0A2U3Y5N5	A0A2U3YND0	Iroquois-class homeodomain protein IRX-1-like.	Transcription factor SOX-9-like.	0.487
LHX1	LOC102737253	A0A2U3XMR7	A0A2U3Z218	LIM/homeobox protein Lhx1.	Glial cell line-derived neurotrophic factor-like isoform X1.	0.406
LHX1	SALL1	A0A2U3XMR7	A0A2U3YRN3	LIM/homeobox protein Lhx1.	Sal-like protein 1-like.	0.623
LHX1	WT1	A0A2U3XMR7	A0A2U3Z0G8	LIM/homeobox protein Lhx1.	Wilms tumor protein-like.	0.697
LOC102726488	IRX1	A0A2U3Z891	A0A2U3Y5N5	Iroquois-class homeodomain protein IRX-2-like.	Iroquois-class homeodomain protein IRX-1-like.	0.537
LOC102727345	IRX1	A0A2U3YND0	A0A2U3Y5N5	Transcription factor SOX-9-like.	Iroquois-class homeodomain protein IRX-1-like.	0.487
LOC102727345	LOC102740547	A0A2U3YND0	A0A2U3Z034	Transcription factor SOX-9-like.	Bone morphogenetic protein 4-like isoform X1.	0.577
LOC102727345	PDGFRA	A0A2U3YND0	A0A2U3YV07	Transcription factor SOX-9-like.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.551
LOC102727345	WT1	A0A2U3YND0	A0A2U3Z0G8	Transcription factor SOX-9-like.	Wilms tumor protein-like.	0.705
LOC102737253	LHX1	A0A2U3Z218	A0A2U3XMR7	Glial cell line-derived neurotrophic factor-like isoform X1.	LIM/homeobox protein Lhx1.	0.406
LOC102737253	LOC102740547	A0A2U3Z218	A0A2U3Z034	Glial cell line-derived neurotrophic factor-like isoform X1.	Bone morphogenetic protein 4-like isoform X1.	0.474
LOC102737253	PDGFRA	A0A2U3Z218	A0A2U3YV07	Glial cell line-derived neurotrophic factor-like isoform X1.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.471
LOC102737253	SALL1	A0A2U3Z218	A0A2U3YRN3	Glial cell line-derived neurotrophic factor-like isoform X1.	Sal-like protein 1-like.	0.475
LOC102740547	GREM1	A0A2U3Z034	A0A2U3XFV2	Bone morphogenetic protein 4-like isoform X1.	Gremlin.	0.820
LOC102740547	LOC102727345	A0A2U3Z034	A0A2U3YND0	Bone morphogenetic protein 4-like isoform X1.	Transcription factor SOX-9-like.	0.577
LOC102740547	LOC102737253	A0A2U3Z034	A0A2U3Z218	Bone morphogenetic protein 4-like isoform X1.	Glial cell line-derived neurotrophic factor-like isoform X1.	0.474
LOC102740547	PDGFRA	A0A2U3Z034	A0A2U3YV07	Bone morphogenetic protein 4-like isoform X1.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.528