STRINGSTRING
SIAH2 SIAH2 DDIT3 DDIT3 EMD EMD TLE3 TLE3 LOC102727190 LOC102727190 FRZB FRZB FRMD8 FRMD8 LOC102732879 LOC102732879 SOSTDC1 SOSTDC1 LATS1 LATS1 DKK4 DKK4 STK4 STK4 PTPRO PTPRO ANKRD6 ANKRD6 WWTR1 WWTR1 LOC102732067 LOC102732067 AXIN1 AXIN1 LOC102731342 LOC102731342 LOC102732739 LOC102732739 NKD1 NKD1 SDHAF2 SDHAF2 GREM1 GREM1 STK3 STK3 NOG NOG FOXO3 FOXO3 CAV1 CAV1 CTNND1 CTNND1 LOC102746429 LOC102746429 LATS2 LATS2 SNAI2 SNAI2 JADE1 JADE1 SHISA3 SHISA3 SFRP2 SFRP2 KIAA0922 KIAA0922 DKK2 DKK2 AMFR AMFR SOX10 SOX10 LOC102736223 LOC102736223 LOC102743045 LOC102743045 DKKL1 DKKL1 LOC102744093 LOC102744093 CTHRC1 CTHRC1 FERMT1 FERMT1 GSK3A GSK3A RUVBL2 RUVBL2 BMP2 BMP2 EGR1 EGR1 AMER1 AMER1 TMEM170B TMEM170B AMER2 AMER2 SFRP5 SFRP5 OTUD5 OTUD5 SFRP4 SFRP4 SOST SOST TMEM88 TMEM88 CCDC88C CCDC88C GLI1 GLI1 CSNK1A1 CSNK1A1 PFDN5 PFDN5 LOC102730272 LOC102730272 SOX17 SOX17 GSK3B GSK3B LOC102747987 LOC102747987 WNT11 WNT11 DACT1 DACT1 TLE2 TLE2 LOC102727345 LOC102727345 CTNNBIP1 CTNNBIP1 SFRP1 SFRP1 FZD4 FZD4 DKK3 DKK3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
EMDEmerin. (260 aa)
TLE3Transducin-like enhancer protein 3-like isoform X5. (726 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
FRMD8FERM domain-containing protein 8. (457 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
DKK4Dickkopf-related protein 4. (221 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
ANKRD6Ankyrin repeat domain-containing protein 6-like. (420 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
AXIN1Axin-1 isoform X1. (867 aa)
LOC102731342Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
LOC102732739Dickkopf-related protein 1-like. (268 aa)
NKD1Protein naked cuticle homolog 1. (363 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
GREM1Gremlin. (184 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXO3Forkhead box protein O3. (672 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CTNND1Catenin delta-1 isoform X2. (1022 aa)
LOC102746429Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (222 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
JADE1Protein Jade-1 isoform X1. (843 aa)
SHISA3Protein shisa-3 homolog. (238 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
KIAA0922Transmembrane protein 131-like. (1601 aa)
DKK2Dickkopf-related protein 2. (259 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (643 aa)
SOX10Transcription factor SOX-10. (469 aa)
LOC102736223Ankyrin repeat domain-containing protein 6-like. (284 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
DKKL1Dickkopf-like protein 1 isoform X3. (237 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (418 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
AMER1APC membrane recruitment protein 1. (1131 aa)
TMEM170BTransmembrane protein 170B. (121 aa)
AMER2APC membrane recruitment protein 2 isoform X1. (688 aa)
SFRP5Secreted frizzled-related protein 5. (289 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (376 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
SOSTSclerostin. (213 aa)
TMEM88Transmembrane protein 88. (159 aa)
CCDC88CProtein Daple. (2021 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
PFDN5Prefoldin subunit 5 isoform X1. (154 aa)
LOC102730272Transducin-like enhancer protein 4-like. (704 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC102747987Nephrocystin-4-like. (369 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DACT1Dapper homolog 1. (523 aa)
TLE2Transducin-like enhancer protein 2 isoform X1. (743 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DKK3Dickkopf-related protein 3. (286 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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