(75 nodes) Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway network (Leptonychotes weddellii)

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Predicted Interactions

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Your Input:
	LOC102736146	3-phosphoinositide-dependent protein kinase 1-like. (216 aa)
	VASN	Vasorin. (676 aa)
	PBLD	Phenazine biosynthesis-like domain-containing protein. (255 aa)
	LOC102744304	EP300-interacting inhibitor of differentiation 2-like. (122 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	DKK2	Dickkopf-related protein 2. (259 aa)
	LOC102740025	Protein sprouty homolog 2-like isoform X1. (315 aa)
	NRROS	Negative regulator of reactive oxygen species. (691 aa)
	TWSG1	Twisted gastrulation protein homolog 1. (223 aa)
	STRAP	Serine-threonine kinase receptor-associated protein isoform X1. (350 aa)
	PMEPA1	Transmembrane prostate androgen-induced protein. (237 aa)
	EMILIN1	EMILIN-1-like. (1013 aa)
	ADAMTSL2	ADAMTS-like protein 2. (955 aa)
	MECOM	MDS1 and EVI1 complex locus protein MDS1. (125 aa)
	HSPA5	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
	LOC102733506	Latent-transforming growth factor beta-binding protein 1-like. (975 aa)
	CER1	Cerberus. (274 aa)
	GLG1	LOW QUALITY PROTEIN: Golgi apparatus protein 1. (641 aa)
	CILP2	Cartilage intermediate layer protein 2. (1157 aa)
	GREM2	Gremlin. (168 aa)
	LDLRAD4	Low-density lipoprotein receptor class A domain-containing protein 4 isoform X1. (269 aa)
	VWC2L	Von Willebrand factor C domain-containing protein 2-like. (222 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	HFE2	Hemojuvelin-like isoform X1. (428 aa)
	SKOR2	SKI family transcriptional corepressor 2. (296 aa)
	LOC102750402	E3 ubiquitin-protein ligase SMURF1-like. (321 aa)
	PRDM16	PR domain zinc finger protein 16-like. (712 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	BCL9L	B-cell CLL/lymphoma 9-like protein isoform X1. (1495 aa)
	LOC102726566	Fibrillin-1-like. (1491 aa)
	LOC102750017	Mothers against decapentaplegic homolog 6-like. (181 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	CILP	LOW QUALITY PROTEIN: cartilage intermediate layer protein 1. (1160 aa)
	FSTL3	Follistatin-related protein 3. (202 aa)
	LOC102740569	Transmembrane protease serine 6-like. (215 aa)
	CHRDL2	Chordin-like protein 2-like. (333 aa)
	LOC102732364	Brorin-like. (133 aa)
	LOC102737090	Sortilin-related receptor-like. (446 aa)
	NANOG	Homeobox protein NANOG. (226 aa)
	FAM89B	Protein FAM89B isoform X1. (192 aa)
	ONECUT2	One cut domain family member. (430 aa)
	LINGO3	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3. (408 aa)
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)
	ZNF451	Probable GPI-anchored adhesin-like protein PGA55 isoform X1. (1063 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (208 aa)
	HIPK2	Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
	SNX25	Sorting nexin-25 isoform X1. (854 aa)
	LOC102731774	Leucine-rich repeat-containing protein 70-like. (510 aa)
	RASL11B	Ras-like protein family member 11B. (248 aa)
	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein. (277 aa)
	TBX20	T-box transcription factor TBX20. (447 aa)
	LEMD3	Inner nuclear membrane protein Man1 isoform X1. (914 aa)
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	SPG20	Spartin isoform X1. (691 aa)
	DAND5	DAN domain family member 5. (190 aa)
	GREM1	Gremlin. (184 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	UCMA	Unique cartilage matrix-associated protein. (138 aa)
	BMPER	BMP-binding endothelial regulator protein-like. (446 aa)
	NOMO1	Nodal modulator 1-like isoform X1. (1222 aa)
	CD109	CD109 antigen. (1322 aa)
	UBL3	Ubiquitin-like protein. (117 aa)
	CTDSPL2	CTD small phosphatase-like protein 2 isoform X1. (466 aa)
	SOST	Sclerostin. (213 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	WFIKKN1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (548 aa)
	FST	Follistatin isoform X1. (344 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog. (237 aa)
	WFIKKN2	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (573 aa)
	LOC102734294	Protein Tob1-like isoform X1. (336 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (252 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (319 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	TP53	A0A2U3YZ15	A0A2U3Y5G3	Tyrosine-protein kinase ABL1-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.503
ADAMTSL2	LOC102726566	A0A2U3YK08	A0A2U3Z1B4	ADAMTS-like protein 2.	Fibrillin-1-like.	0.666
ADAMTSL2	LOC102733506	A0A2U3YK08	A0A2U3YKP7	ADAMTS-like protein 2.	Latent-transforming growth factor beta-binding protein 1-like.	0.683
BAMBI	BMP2	A0A2U3YAH6	A0A2U3Z3S1	BMP and activin membrane-bound inhibitor homolog.	Bone morphogenetic protein 2-like.	0.526
BAMBI	LOC102726900	A0A2U3YAH6	A0A2U3XYM0	BMP and activin membrane-bound inhibitor homolog.	Mothers against decapentaplegic homolog 7-like.	0.983
BAMBI	LOC102750017	A0A2U3YAH6	A0A2U3Z1Z6	BMP and activin membrane-bound inhibitor homolog.	Mothers against decapentaplegic homolog 6-like.	0.766
BAMBI	NOG	A0A2U3YAH6	A0A2U3XEL8	BMP and activin membrane-bound inhibitor homolog.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.400
BAMBI	SFRP2	A0A2U3YAH6	A0A2U3X789	BMP and activin membrane-bound inhibitor homolog.	Secreted frizzled-related protein 2.	0.629
BMP2	BAMBI	A0A2U3Z3S1	A0A2U3YAH6	Bone morphogenetic protein 2-like.	BMP and activin membrane-bound inhibitor homolog.	0.526
BMP2	BMPER	A0A2U3Z3S1	A0A2U3XBU2	Bone morphogenetic protein 2-like.	BMP-binding endothelial regulator protein-like.	0.415
BMP2	CER1	A0A2U3Z3S1	A0A2U3YL33	Bone morphogenetic protein 2-like.	Cerberus.	0.496
BMP2	CHRDL2	A0A2U3Z3S1	A0A2U3Z5T0	Bone morphogenetic protein 2-like.	Chordin-like protein 2-like.	0.457
BMP2	DAND5	A0A2U3Z3S1	A0A2U3XH14	Bone morphogenetic protein 2-like.	DAN domain family member 5.	0.475
BMP2	FST	A0A2U3Z3S1	A0A2U3Y6I2	Bone morphogenetic protein 2-like.	Follistatin isoform X1.	0.589
BMP2	GREM1	A0A2U3Z3S1	A0A2U3XFV2	Bone morphogenetic protein 2-like.	Gremlin.	0.820
BMP2	GREM2	A0A2U3Z3S1	A0A2U3YMC2	Bone morphogenetic protein 2-like.	Gremlin.	0.832
BMP2	HFE2	A0A2U3Z3S1	A0A2U3YU51	Bone morphogenetic protein 2-like.	Hemojuvelin-like isoform X1.	0.707
BMP2	LOC102726900	A0A2U3Z3S1	A0A2U3XYM0	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 7-like.	0.709
BMP2	LOC102750017	A0A2U3Z3S1	A0A2U3Z1Z6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog 6-like.	0.743
BMP2	LOC102750402	A0A2U3Z3S1	A0A2U3YYE4	Bone morphogenetic protein 2-like.	E3 ubiquitin-protein ligase SMURF1-like.	0.620