STRINGSTRING
ANKRD66 ANKRD66 TNNI3K TNNI3K ASB15 ASB15 PDE4D PDE4D LOC102738933 LOC102738933 LOC102734924 LOC102734924 TACR2 TACR2 CAV1 CAV1 SRI SRI FOXO3 FOXO3 GJA5 GJA5 TWF1 TWF1 ARHGAP42 ARHGAP42 ADRA2B ADRA2B IGF1 IGF1 MYOG MYOG TNNC1 TNNC1 KCNJ2 KCNJ2 TMEM38B TMEM38B LOC102734862 LOC102734862 LOC102741278 LOC102741278 CAMK2G CAMK2G DLG2 DLG2 LOC102735672 LOC102735672 SMAD4 SMAD4 KBTBD13 KBTBD13 PAWR PAWR LOC102735676 LOC102735676 F2R F2R ADRA2A ADRA2A PDE4B PDE4B KCNQ1 KCNQ1 LOC102751226 LOC102751226 LOC102726900 LOC102726900 LOC102739889 LOC102739889 CAV3 CAV3 LMCD1 LMCD1 LOC102738191 LOC102738191 SRF SRF CTTN CTTN ADRA1A ADRA1A LOC102750159 LOC102750159 P2RX4 P2RX4 LOC102732685 LOC102732685 TNFRSF1A TNFRSF1A LOC102744643 LOC102744643 TBXA2R TBXA2R LOC102746494 LOC102746494 SLC9A1 SLC9A1 PROK2 PROK2 TRPC3 TRPC3 SGCA SGCA ANKRD52 ANKRD52 HDAC4 HDAC4 PRKG1 PRKG1 PLN PLN NOL3 NOL3 TNNI3 TNNI3 CASQ1 CASQ1 UCN UCN ADRBK1 ADRBK1 TMEM8C TMEM8C PARP1 PARP1 ZDHHC21 ZDHHC21 JUP JUP FKBP1B FKBP1B ANKRD28 ANKRD28 CHRM2 CHRM2 LOC102745190 LOC102745190 MEF2A MEF2A ADRA1B ADRA1B LOC102749794 LOC102749794 TIFAB TIFAB LOC102744274 LOC102744274 TNNT3 TNNT3 LOC102743456 LOC102743456 GPER1 GPER1 LOC102731337 LOC102731337 LOC102743250 LOC102743250 ANXA6 ANXA6 GSK3A GSK3A TMEM38A TMEM38A DMPK DMPK LOC102727186 LOC102727186 TNNC2 TNNC2 LOC102730732 LOC102730732 LOC102732556 LOC102732556 LOC102733954 LOC102733954 LMNA LMNA LOC102745857 LOC102745857 LOC102750433 LOC102750433 LOC102734167 LOC102734167 LOC102730020 LOC102730020 LOC102735756 LOC102735756
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANKRD66Ankyrin repeat domain-containing protein 66. (197 aa)
TNNI3KSerine/threonine-protein kinase TNNI3K. (435 aa)
ASB15Ankyrin repeat and SOCS box protein 15. (588 aa)
PDE4DPhosphodiesterase. (811 aa)
LOC102738933Catenin alpha-3-like. (530 aa)
LOC102734924Spexin. (115 aa)
TACR2substance-K receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SRISorcin. (198 aa)
FOXO3Forkhead box protein O3. (672 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TWF1Twinfilin-1 isoform X2. (357 aa)
ARHGAP42Rho GTPase-activating protein 42. (874 aa)
ADRA2Balpha-2B adrenergic receptor. (444 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
MYOGMyogenin. (224 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
KCNJ2Inward rectifier potassium channel 2 isoform X1. (427 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
LOC102735672Myotrophin-like. (118 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
KBTBD13Kelch repeat and BTB domain-containing protein 13. (459 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
LOC102735676substance-P receptor-like. (212 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADRA2Aalpha-2A adrenergic receptor. (350 aa)
PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4B. (284 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
LOC102751226Peptidase inhibitor 16-like. (304 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
LOC102739889Dedicator of cytokinesis protein 4-like. (137 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LMCD1LIM and cysteine-rich domains protein 1. (290 aa)
LOC102738191Dedicator of cytokinesis protein 4-like isoform X1; Belongs to the DOCK family. (846 aa)
SRFSerum response factor. (508 aa)
CTTNSrc substrate cortactin. (545 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
LOC102750159Junction plakoglobin-like. (503 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
LOC102732685Glutaredoxin-3-like; Belongs to the universal ribosomal protein uL11 family. (355 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
LOC102744643Short transient receptor potential channel 3-like. (453 aa)
TBXA2RThromboxane A2 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (343 aa)
LOC102746494Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (226 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
PROK2Prokineticin-2 isoform X2. (108 aa)
TRPC3Short transient receptor potential channel 3-like. (592 aa)
SGCAAlpha-sarcoglycan. (386 aa)
ANKRD52Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C. (1076 aa)
HDAC4Histone deacetylase 4-like. (667 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
NOL3Nucleolar protein 3. (212 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (211 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (393 aa)
UCNUrocortin. (126 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
TMEM8CProtein myomaker. (221 aa)
PARP1Poly [ADP-ribose] polymerase. (686 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
JUPJunction plakoglobin. (307 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ANKRD28Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3. (899 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
LOC102745190Dystrophin-like. (642 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (487 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
LOC102749794Glutaredoxin-3-like. (288 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (166 aa)
LOC102744274Dystrophin-like. (456 aa)
TNNT3Troponin T, fast skeletal muscle. (230 aa)
LOC102743456Serine/threonine-protein kinase TNNI3K-like. (440 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC102731337Protein-histidine N-methyltransferase. (244 aa)
LOC102743250Transcription factor GATA-5-like. (300 aa)
ANXA6Annexin. (673 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
TMEM38ATrimeric intracellular cation channel type A. (252 aa)
DMPKMyotonin-protein kinase. (543 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
TNNC2Troponin C, skeletal muscle. (160 aa)
LOC102730732Sarcalumenin-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (379 aa)
LOC102732556Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
LOC102745857Phosphodiesterase. (503 aa)
LOC102750433Histone-lysine N-methyltransferase setd3-like. (117 aa)
LOC102734167Neurogenin-1-like. (250 aa)
LOC102730020Myosin-7-like. (703 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.