STRINGSTRING
LOC102740025 LOC102740025 FGF16 FGF16 DKK2 DKK2 LRIT3 LRIT3 SFRP2 SFRP2 CTDSPL2 CTDSPL2 FGF9 FGF9 LATS2 LATS2 LOC102726446 LOC102726446 UBL3 UBL3 CD109 CD109 CD63 CD63 LOX LOX BMPER BMPER CAV1 CAV1 WNT1 WNT1 WASF1 WASF1 KIAA1324L KIAA1324L FGF10 FGF10 NOG NOG EP300 EP300 GREM1 GREM1 LOC102737759 LOC102737759 DAND5 DAND5 FBXL15 FBXL15 SPG20 SPG20 PELO PELO SULF1 SULF1 DLX1 DLX1 PRDM14 PRDM14 LEMD3 LEMD3 AXIN1 AXIN1 GIPC2 GIPC2 ILK ILK LOC102732067 LOC102732067 TGFBR3L TGFBR3L TBX20 TBX20 TNFAIP6 TNFAIP6 RASL11B RASL11B CYR61 CYR61 BMPR2 BMPR2 LOC102731774 LOC102731774 MPP5 MPP5 SMAD4 SMAD4 SNX25 SNX25 HIPK2 HIPK2 LATS1 LATS1 RNF111 RNF111 GRB10 GRB10 SOSTDC1 SOSTDC1 ZNF451 ZNF451 LOC102732879 LOC102732879 LOC102726900 LOC102726900 CAV3 CAV3 SPRY3 SPRY3 ONECUT2 ONECUT2 FAM89B FAM89B ZDHHC17 ZDHHC17 GIPC1 GIPC1 SFRP5 SFRP5 NANOG NANOG HIF1A HIF1A LOC102737090 LOC102737090 STRAP STRAP GIPC3 GIPC3 SOST SOST TP53 TP53 WFIKKN1 WFIKKN1 FST FST PTP4A3 PTP4A3 SPRY4 SPRY4 SDCBP SDCBP PIN1 PIN1 BAMBI BAMBI CITED1 CITED1 WFIKKN2 WFIKKN2 ADAMTS3 ADAMTS3 LOC102734294 LOC102734294 NKX2-1 NKX2-1 GATA3 GATA3 SPRY1 SPRY1 GPR124 GPR124 MYO1C MYO1C NRROS NRROS LOC102748382 LOC102748382 THBS1 THBS1 FSTL1 FSTL1 TWSG1 TWSG1 LOC102728249 LOC102728249 PMEPA1 PMEPA1 PDCD6 PDCD6 HGS HGS EMILIN1 EMILIN1 CXCL13 CXCL13 ACVRL1 ACVRL1 MSX1 MSX1 HHIP HHIP ADAMTSL2 ADAMTSL2 LOC102733211 LOC102733211 MECOM MECOM HSPA5 HSPA5 LOC102733506 LOC102733506 CER1 CER1 SULF2 SULF2 GLG1 GLG1 FLCN FLCN DLL1 DLL1 GREM2 GREM2 LDLRAD4 LDLRAD4 LOC102742614 LOC102742614 SEMA6A SEMA6A FGF4 FGF4 FGF18 FGF18 LRG1 LRG1 CDKN2B CDKN2B CDKN2A CDKN2A VWC2L VWC2L SHISA2 SHISA2 LOC102737831 LOC102737831 SFRP1 SFRP1 CREBBP CREBBP TMEM108 TMEM108 GDF5 GDF5 FZD4 FZD4 FGFBP3 FGFBP3 HFE2 HFE2 SKOR2 SKOR2 TGFB1 TGFB1 CREB3L1 CREB3L1 MMRN2 MMRN2 NOTCH2 NOTCH2 LOC102750402 LOC102750402 PRDM16 PRDM16 IL17F IL17F LOC102743151 LOC102743151 ABL1 ABL1 CITED2 CITED2 LOC102749531 LOC102749531 LOC102743045 LOC102743045 BCL9L BCL9L LOC102740547 LOC102740547 LOC102727675 LOC102727675 KIAA1462 KIAA1462 ING2 ING2 FERMT1 FERMT1 LOC102726566 LOC102726566 LOC102740157 LOC102740157 LOC102750017 LOC102750017 LOC102730318 LOC102730318 LOC102731237 LOC102731237 LOC102730108 LOC102730108 FGF2 FGF2 ZNF423 ZNF423 AGT AGT BMP2 BMP2 GPC1 GPC1 TMEM204 TMEM204 ZNF703 ZNF703 FSTL3 FSTL3 LOC102744822 LOC102744822 LOC102747049 LOC102747049 LOC102740569 LOC102740569 CHRDL2 CHRDL2 LOC102732364 LOC102732364 LINGO3 LINGO3 LOC102736146 LOC102736146 VASN VASN LOC102727190 LOC102727190 PBLD PBLD LOC102731463 LOC102731463 LOC102744304 LOC102744304
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DKK2Dickkopf-related protein 2. (259 aa)
LRIT3Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3. (681 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (466 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
UBL3Ubiquitin-like protein. (117 aa)
CD109CD109 antigen. (1322 aa)
CD63Tetraspanin. (238 aa)
LOXProtein-lysine 6-oxidase isoform X1. (415 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
KIAA1324LUPF0577 protein KIAA1324-like homolog isoform X1. (915 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EP300Histone acetyltransferase p300. (2425 aa)
GREM1Gremlin. (184 aa)
LOC102737759Cytoplasmic FMR1-interacting protein 2-like. (113 aa)
DAND5DAN domain family member 5. (190 aa)
FBXL15F-box/LRR-repeat protein 15. (300 aa)
SPG20Spartin isoform X1. (691 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
LEMD3Inner nuclear membrane protein Man1 isoform X1. (914 aa)
AXIN1Axin-1 isoform X1. (867 aa)
GIPC2PDZ domain-containing protein GIPC2. (312 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (292 aa)
TBX20T-box transcription factor TBX20. (447 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
RASL11BRas-like protein family member 11B. (248 aa)
CYR61Protein CYR61. (382 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
LOC102731774Leucine-rich repeat-containing protein 70-like. (510 aa)
MPP5MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SNX25Sorting nexin-25 isoform X1. (854 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X1. (994 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
ZNF451Probable GPI-anchored adhesin-like protein PGA55 isoform X1. (1063 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
ONECUT2One cut domain family member. (430 aa)
FAM89BProtein FAM89B isoform X1. (192 aa)
ZDHHC17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa)
GIPC1PDZ domain-containing protein GIPC1. (333 aa)
SFRP5Secreted frizzled-related protein 5. (289 aa)
NANOGHomeobox protein NANOG. (226 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC102737090Sortilin-related receptor-like. (446 aa)
STRAPSerine-threonine kinase receptor-associated protein isoform X1. (350 aa)
GIPC3PDZ domain-containing protein GIPC3. (312 aa)
SOSTSclerostin. (213 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WFIKKN1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (548 aa)
FSTFollistatin isoform X1. (344 aa)
PTP4A3Protein tyrosine phosphatase type IVA 3 isoform X1. (173 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
SDCBPSyntenin-1 isoform X1. (298 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (237 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (573 aa)
ADAMTS3A disintegrin and metalloproteinase with thrombospondin motifs 3. (1202 aa)
LOC102734294Protein Tob1-like isoform X1. (336 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
GPR124G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1332 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
LOC102748382Docking protein 5-like. (203 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
FSTL1Follistatin-related protein 1 isoform X1. (307 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
LOC102728249UPF0687 protein C20orf27 homolog isoform X1. (174 aa)
PMEPA1Transmembrane prostate androgen-induced protein. (237 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (781 aa)
EMILIN1EMILIN-1-like. (1013 aa)
CXCL13c-X-C motif chemokine 13. (110 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MSX1Homeobox protein MSX-1. (303 aa)
HHIPHedgehog-interacting protein-like. (662 aa)
ADAMTSL2ADAMTS-like protein 2. (955 aa)
LOC102733211Neuronal regeneration-related protein-like. (68 aa)
MECOMMDS1 and EVI1 complex locus protein MDS1. (125 aa)
HSPA578 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
LOC102733506Latent-transforming growth factor beta-binding protein 1-like. (975 aa)
CER1Cerberus. (274 aa)
SULF2N-acetylglucosamine-6-sulfatase. (412 aa)
GLG1LOW QUALITY PROTEIN: Golgi apparatus protein 1. (641 aa)
FLCNFolliculin. (579 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
GREM2Gremlin. (168 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform X1. (269 aa)
LOC102742614Peripheral plasma membrane protein CASK-like. (818 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
FGF18Fibroblast growth factor 18. (116 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (354 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
SHISA2Protein shisa-2 homolog. (295 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
CREBBPCREB-binding protein-like. (1411 aa)
TMEM108Transmembrane protein 108. (581 aa)
GDF5Growth/differentiation factor 5. (499 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FGFBP3Fibroblast growth factor-binding protein 3. (255 aa)
HFE2Hemojuvelin-like isoform X1. (428 aa)
SKOR2SKI family transcriptional corepressor 2. (296 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
MMRN2Multimerin-2-like. (799 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
LOC102750402E3 ubiquitin-protein ligase SMURF1-like. (321 aa)
PRDM16PR domain zinc finger protein 16-like. (712 aa)
IL17Finterleukin-17F. (157 aa)
LOC102743151RING finger protein 165-like. (326 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X1. (1495 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102727675Decorin; May affect the rate of fibrils formation. (360 aa)
KIAA1462Junctional protein associated with coronary artery disease-like. (1360 aa)
ING2Inhibitor of growth protein. (280 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
LOC102726566Fibrillin-1-like. (1491 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
LOC102750017Mothers against decapentaplegic homolog 6-like. (181 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102731237SNW domain-containing protein 1-like. (340 aa)
LOC102730108Neuropilin-1-like. (465 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
ZNF423Zinc finger protein 423-like. (1075 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
GPC1Glypican-1-like; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
TMEM204Transmembrane protein 204. (226 aa)
ZNF703Zinc finger protein 703-like. (591 aa)
FSTL3Follistatin-related protein 3. (202 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
LOC102747049Signal peptide, CUB and EGF-like domain-containing protein 3-like. (624 aa)
LOC102740569Transmembrane protease serine 6-like. (215 aa)
CHRDL2Chordin-like protein 2-like. (333 aa)
LOC102732364Brorin-like. (133 aa)
LINGO3Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3. (408 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
VASNVasorin. (676 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
PBLDPhenazine biosynthesis-like domain-containing protein. (255 aa)
LOC102731463Transcription factor AP-2-beta-like. (180 aa)
LOC102744304EP300-interacting inhibitor of differentiation 2-like. (122 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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