(19 nodes) Cellular senescence network (Leptonychotes weddellii)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
	BRCA2	Breast cancer type 2 susceptibility protein homolog. (2818 aa)
	SMC5	Structural maintenance of chromosomes protein 5-like isoform X2. (1091 aa)
	HMGA2	High mobility group protein HMGI-C. (109 aa)
	SMC6	Structural maintenance of chromosomes protein 6. (1097 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1. (957 aa)
	SRF	Serum response factor. (508 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	TBX3	T-box transcription factor TBX3. (675 aa)
	PML	Protein PML. (880 aa)
	NUP62	Nuclear pore glycoprotein p62. (525 aa)
	HMGA1	High mobility group protein HMG-I/HMG-Y isoform X1. (107 aa)
	LOC102748904	Augurin. (147 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (271 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
	LMNA	prelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
	LOC102726484	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
	LOC102733867	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDKN1A	A0A2U3YZ15	A0A2U3Z5P5	Tyrosine-protein kinase ABL1-like.	Cyclin-dependent kinase inhibitor 1 isoform X1.	0.585
ABL1	TP53	A0A2U3YZ15	A0A2U3Y5G3	Tyrosine-protein kinase ABL1-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.503
BRCA2	LOC102733867	A0A2U3XC46	A0A2U3Z7B1	Breast cancer type 2 susceptibility protein homolog.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.414
BRCA2	TP53	A0A2U3XC46	A0A2U3Y5G3	Breast cancer type 2 susceptibility protein homolog.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.879
CDKN1A	ABL1	A0A2U3Z5P5	A0A2U3YZ15	Cyclin-dependent kinase inhibitor 1 isoform X1.	Tyrosine-protein kinase ABL1-like.	0.585
CDKN1A	LOC102733867	A0A2U3Z5P5	A0A2U3Z7B1	Cyclin-dependent kinase inhibitor 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.548
CDKN1A	TP53	A0A2U3Z5P5	A0A2U3Y5G3	Cyclin-dependent kinase inhibitor 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.993
HMGA1	HMGA2	A0A2U3YMX6	A0A2U3XIU9	High mobility group protein HMG-I/HMG-Y isoform X1.	High mobility group protein HMGI-C.	0.831
HMGA2	HMGA1	A0A2U3XIU9	A0A2U3YMX6	High mobility group protein HMGI-C.	High mobility group protein HMG-I/HMG-Y isoform X1.	0.831
HMGA2	TP53	A0A2U3XIU9	A0A2U3Y5G3	High mobility group protein HMGI-C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.400
LMNA	TP53	A0A2U3Z6T9	A0A2U3Y5G3	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.512
LOC102726484	WNT16	A0A2U3Z6V5	A0A2U3X969	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.914
LOC102733867	BRCA2	A0A2U3Z7B1	A0A2U3XC46	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Breast cancer type 2 susceptibility protein homolog.	0.414
LOC102733867	CDKN1A	A0A2U3Z7B1	A0A2U3Z5P5	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cyclin-dependent kinase inhibitor 1 isoform X1.	0.548
LOC102733867	TP53	A0A2U3Z7B1	A0A2U3Y5G3	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.819
PML	TP53	A0A2U3YBC0	A0A2U3Y5G3	Protein PML.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.814
SMC5	SMC6	A0A2U3XDM8	A0A2U3XNI3	Structural maintenance of chromosomes protein 5-like isoform X2.	Structural maintenance of chromosomes protein 6.	0.998
SMC6	SMC5	A0A2U3XNI3	A0A2U3XDM8	Structural maintenance of chromosomes protein 6.	Structural maintenance of chromosomes protein 5-like isoform X2.	0.998
TP53	ABL1	A0A2U3Y5G3	A0A2U3YZ15	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tyrosine-protein kinase ABL1-like.	0.503
TP53	BRCA2	A0A2U3Y5G3	A0A2U3XC46	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Breast cancer type 2 susceptibility protein homolog.	0.879