STRINGSTRING
YAP1 YAP1 INHBA INHBA TGFB1 TGFB1 DEDD DEDD IL18 IL18 DDX47 DDX47 LOC102743896 LOC102743896 PARP2 PARP2 STK3 STK3 FGF10 FGF10 FOXO3 FOXO3 COL2A1 COL2A1 ERBB3 ERBB3 LOC102745146 LOC102745146 HIPK1 HIPK1 MLLT11 MLLT11 MCL1 MCL1 BCL2L1 BCL2L1 LOC102733223 LOC102733223 IL7 IL7 RB1CC1 RB1CC1 G0S2 G0S2 GSK3A GSK3A BCL2A1 BCL2A1 IFNG IFNG RAF1 RAF1 PML PML TRADD TRADD KRT18 KRT18 PIDD PIDD GSK3B GSK3B LOC102746004 LOC102746004 EYA1 EYA1 ITPRIPL2 ITPRIPL2 EYA2 EYA2 YJEFN3 YJEFN3 NDUFA13 NDUFA13 SFRP1 SFRP1 LOC102736516 LOC102736516 LOC102730318 LOC102730318 NF1 NF1 BCL2L2 BCL2L2 CASP8 CASP8 LOC102743045 LOC102743045 CASP8AP2 CASP8AP2 DEDD2 DEDD2 CASP2 CASP2 LOC102751021 LOC102751021 LOC102732459 LOC102732459 LOC102736146 LOC102736146 LOC102744407 LOC102744407 LOC102745948 LOC102745948 BOK BOK LOC102729504 LOC102729504 KIAA0141 KIAA0141 NGF NGF KITLG KITLG TNF TNF SIVA1 SIVA1 TGFB2 TGFB2 DDX3X DDX3X IL2 IL2 BAK1 BAK1 FASLG FASLG P2RX7 P2RX7 FADD FADD CTTN CTTN FGFR3 FGFR3 LOC102732879 LOC102732879 STK4 STK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YAP1Yorkie homolog. (326 aa)
INHBAInhibin beta A chain. (424 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
DEDDDeath effector domain-containing protein isoform X1. (318 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
DDX47Probable ATP-dependent RNA helicase DDX47 isoform X1; Belongs to the DEAD box helicase family. (455 aa)
LOC102743896Thioredoxin; Belongs to the thioredoxin family. (121 aa)
PARP2Poly [ADP-ribose] polymerase. (567 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FOXO3Forkhead box protein O3. (672 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X2. (1080 aa)
MLLT11Protein AF1q. (89 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1. (350 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC102733223Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family. (294 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
G0S2G0/G1 switch protein 2. (103 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
BCL2A1Bcl-2-related protein A1. (174 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PMLProtein PML. (880 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
KRT18Keratin, type I cytoskeletal 18 isoform X1; Belongs to the intermediate filament family. (430 aa)
PIDDP53-induced protein with a death domain. (916 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (251 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
NF1Neurofibromin-like. (1269 aa)
BCL2L2Bcl-2-like protein 2 isoform X1. (193 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
CASP8AP2CASP8-associated protein 2. (1969 aa)
DEDD2DNA-binding death effector domain-containing protein 2-like. (328 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (312 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102732459E3 ubiquitin-protein ligase NRDP1-like. (317 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102744407Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (184 aa)
LOC102745948CD27 antigen-like. (261 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
KIAA0141Death ligand signal enhancer. (522 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
CTTNSrc substrate cortactin. (545 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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