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PTCH1 PTCH1 GNG2 GNG2 SFRP1 SFRP1 SCNN1G SCNN1G P2RY6 P2RY6 LOC102728392 LOC102728392 AHR AHR ADCY6 ADCY6 CFTR CFTR RECQL5 RECQL5 PTGFR PTGFR LRP6 LRP6 PTGER4 PTGER4 PRKAA1 PRKAA1 CREB1 CREB1 ADAM15 ADAM15 TNFSF4 TNFSF4 PTGER2 PTGER2 LOC102746012 LOC102746012 SPHK2 SPHK2 LOC102735509 LOC102735509 JUP JUP RAD51 RAD51 PTRHD1 PTRHD1 MAP4K1 MAP4K1 GPLD1 GPLD1 MLC1 MLC1 LOC102729506 LOC102729506 NPAS4 NPAS4 GLRA4 GLRA4 P2RY4 P2RY4 LOC102750159 LOC102750159 LOC102730564 LOC102730564 LOC102745156 LOC102745156 NFE2L1 NFE2L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Protein patched homolog 1. (1301 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
SCNN1GAmiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
P2RY6P2Y purinoceptor 6. (328 aa)
LOC102728392ephrin-A5-like; Belongs to the ephrin family. (191 aa)
AHRAryl hydrocarbon receptor. (843 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
RECQL5ATP-dependent DNA helicase Q5. (408 aa)
PTGFRProstaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (867 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
LOC102735509Oxysterol-binding protein-related protein 7-like. (241 aa)
JUPJunction plakoglobin. (307 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (267 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
MAP4K1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
MLC1Membrane protein MLC1. (373 aa)
LOC102729506GRAM domain-containing protein 1B-like. (248 aa)
NPAS4Neuronal PAS domain-containing protein 4. (800 aa)
GLRA4Glycine receptor subunit alpha-4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
P2RY4P2Y purinoceptor 4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
LOC102750159Junction plakoglobin-like. (503 aa)
LOC102730564Golgi phosphoprotein 3-like. (300 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
NFE2L1Nuclear factor erythroid 2-related factor 1 isoform X3. (622 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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