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LOC102744822 LOC102744822 LOC102745703 LOC102745703 LOC102726446 LOC102726446 ALOX5 ALOX5 ITGA5 ITGA5 BMPER BMPER GLUL GLUL IL10 IL10 SYNJ2BP SYNJ2BP E2F2 E2F2 THBS1 THBS1 SMAD1 SMAD1 DLL1 DLL1 RHOJ RHOJ SEMA6A SEMA6A FUT1 FUT1 CREB3L1 CREB3L1 S100A1 S100A1 KIAA1462 KIAA1462 FGF2 FGF2 JMJD8 JMJD8 LOC102736146 LOC102736146 LOC102749847 LOC102749847
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
LOC102745703Pyruvate kinase; Belongs to the pyruvate kinase family. (610 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
GLULGlutamine synthetase. (413 aa)
IL10Interleukin-10. (178 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
E2F2Transcription factor E2F2. (440 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (408 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
KIAA1462Junctional protein associated with coronary artery disease-like. (1360 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
JMJD8jmjC domain-containing protein 8. (296 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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