STRINGSTRING
FBXW7 FBXW7 LRRK2 LRRK2 CLUL1 CLUL1 CAV1 CAV1 SH3RF1 SH3RF1 NDNL2 NDNL2 RFWD2 RFWD2 RAD23A RAD23A ZYG11A ZYG11A PLK1 PLK1 AGBL4 AGBL4 AXIN1 AXIN1 DDRGK1 DDRGK1 DVL1 DVL1 CDC20B CDC20B PTEN PTEN DET1 DET1 LOC102732067 LOC102732067 SH3RF3 SH3RF3 GBA GBA FBXO22 FBXO22 SOCS4 SOCS4 LOC102726900 LOC102726900 USP5 USP5 HSPA1L HSPA1L LOC102734190 LOC102734190 FZR1 FZR1 SIRT6 SIRT6 SIRT2 SIRT2 TRIB1 TRIB1 DNAJB2 DNAJB2 CDC20 CDC20 MDM2 MDM2 RCHY1 RCHY1 MKRN2 MKRN2 BBS7 BBS7 CSNK1D CSNK1D TRIM67 TRIM67 LOC102731085 LOC102731085 GSK3B GSK3B RNF139 RNF139 NUB1 NUB1 CCDC22 CCDC22 LOC102744361 LOC102744361 HERPUD1 HERPUD1 GNB2L1 GNB2L1 SOCS5 SOCS5 CSNK1E CSNK1E LOC102743039 LOC102743039 HSPBP1 HSPBP1 LOC102750402 LOC102750402 ZER1 ZER1 PSMD10 PSMD10 PIAS1 PIAS1 DDA1 DDA1 LOC102742052 LOC102742052 LOC102730319 LOC102730319 GSK3A GSK3A FBXW9 FBXW9 SH3RF2 SH3RF2 LOC102734159 LOC102734159 LOC102735556 LOC102735556 LOC102733647 LOC102733647 ARIH2 ARIH2 CBFA2T3 CBFA2T3 LOC102750518 LOC102750518 LOC102727706 LOC102727706 LOC102750030 LOC102750030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
CLUL1Clusterin-like protein 1. (288 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (872 aa)
NDNL2Melanoma-associated antigen G1. (284 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2-like isoform X1. (570 aa)
RAD23AUV excision repair protein RAD23 homolog A isoform X1. (363 aa)
ZYG11ALOW QUALITY PROTEIN: protein zyg-11 homolog A. (784 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
AGBL4Cytosolic carboxypeptidase 6. (204 aa)
AXIN1Axin-1 isoform X1. (867 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
CDC20BCell division cycle protein 20 homolog B. (454 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DET1DET1 homolog. (550 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
SH3RF3SH3 domain-containing RING finger protein 3. (599 aa)
GBAGlucosylceramidase. (536 aa)
FBXO22F-box only protein 22. (408 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC102734190Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
FZR1Fizzy-related protein homolog isoform X1. (496 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
TRIB1Tribbles homolog 1. (292 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X2. (278 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
CSNK1DCasein kinase I isoform delta isoform X2. (399 aa)
TRIM67Tripartite motif-containing protein 67. (656 aa)
LOC102731085RBR-type E3 ubiquitin transferase. (856 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RNF139E3 ubiquitin-protein ligase RNF139. (664 aa)
NUB1NEDD8 ultimate buster 1. (561 aa)
CCDC22Coiled-coil domain-containing protein 22-like. (627 aa)
LOC102744361Small glutamine-rich tetratricopeptide repeat-containing protein alpha-like. (76 aa)
HERPUD1annotation not available (367 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2. (359 aa)
LOC102743039Protein FAM122A-like. (287 aa)
HSPBP1Hsp70-binding protein 1 isoform X1. (421 aa)
LOC102750402E3 ubiquitin-protein ligase SMURF1-like. (321 aa)
ZER1Protein zer-1 homolog. (467 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (653 aa)
DDA1DET1- and DDB1-associated protein 1 isoform X2. (102 aa)
LOC102742052Protein zer-1 homolog. (176 aa)
LOC102730319Melanoma-associated antigen F1-like. (323 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2-like. (521 aa)
LOC102734159Small glutamine-rich tetratricopeptide repeat-containing protein alpha-like. (266 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102733647Tribbles homolog 2-like. (188 aa)
ARIH2RBR-type E3 ubiquitin transferase. (385 aa)
CBFA2T3Protein CBFA2T3-like. (343 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102727706Protein zer-1 homolog. (208 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.