STRINGSTRING
HGF HGF LOC102735317 LOC102735317 JADE1 JADE1 TEN1 TEN1 PARN PARN RFC3 RFC3 POT1 POT1 NEK7 NEK7 TERF2 TERF2 GREM1 GREM1 PARP3 PARP3 JADE3 JADE3 CCT2 CCT2 GINS3 GINS3 FGFR4 FGFR4 LOC102729635 LOC102729635 LOC102729936 LOC102729936 SRC SRC LOC102746870 LOC102746870 SH2B1 SH2B1 MAP3K4 MAP3K4 BMPR2 BMPR2 PRKCQ PRKCQ LOC102740480 LOC102740480 EXOSC10 EXOSC10 PCNA PCNA CCT3 CCT3 FBXO4 FBXO4 DKC1 DKC1 LOC102727215 LOC102727215 HMBOX1 HMBOX1 POLG2 POLG2 ING4 ING4 ANKRD1 ANKRD1 CTC1 CTC1 TFDP1 TFDP1 TP53 TP53 WRAP53 WRAP53 TINF2 TINF2 TNKS TNKS RFC4 RFC4 CCDC174 CCDC174 ACVRL1 ACVRL1 MAPK1 MAPK1 ATM ATM DSCC1 DSCC1 RFC2 RFC2 LOC102737831 LOC102737831 GINS4 GINS4 PDGFB PDGFB DCP2 DCP2 LOC102730087 LOC102730087 LOC102744478 LOC102744478 LOC102735621 LOC102735621 KAT7 KAT7 NEK2 NEK2 LOC102749531 LOC102749531 LOC102747042 LOC102747042 LOC102730835 LOC102730835 FGF2 FGF2 HNRNPU HNRNPU CDKN1A CDKN1A ACD ACD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
LOC102735317Dachshund homolog 1-like. (666 aa)
JADE1Protein Jade-1 isoform X1. (843 aa)
TEN1CST complex subunit TEN1. (136 aa)
PARNpoly(A)-specific ribonuclease PARN isoform X1. (638 aa)
RFC3Replication factor C subunit 3. (356 aa)
POT1Protection of telomeres protein 1-like. (516 aa)
NEK7Serine/threonine-protein kinase Nek7; Belongs to the protein kinase superfamily. (285 aa)
TERF2Telomeric repeat-binding factor 2. (542 aa)
GREM1Gremlin. (184 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
JADE3Protein Jade-3. (823 aa)
CCT2T-complex protein 1 subunit beta. (543 aa)
GINS3DNA replication complex GINS protein PSF3 isoform X1. (216 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
LOC102729635Coiled-coil domain-containing protein 174-like. (465 aa)
LOC102729936T-complex protein 1 subunit alpha-like. (556 aa)
SRCTyrosine-protein kinase. (536 aa)
LOC102746870Chromosome transmission fidelity protein 8 homolog. (117 aa)
SH2B1SH2B adapter protein 1 isoform X3. (688 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1605 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC102740480DNA replication complex GINS protein PSF2-like. (114 aa)
EXOSC10Exosome component 10 isoform X1. (887 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
FBXO4F-box only protein 4. (387 aa)
DKC1H/ACA ribonucleoprotein complex subunit 4 isoform X1. (517 aa)
LOC102727215Niban-like protein 1-like. (398 aa)
HMBOX1Homeobox-containing protein 1 isoform X1. (443 aa)
POLG2DNA polymerase subunit gamma-2, mitochondrial. (266 aa)
ING4Inhibitor of growth protein. (249 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
CTC1CST complex subunit CTC1. (1218 aa)
TFDP1Transcription factor. (290 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (481 aa)
TNKSPoly [ADP-ribose] polymerase. (1328 aa)
RFC4Replication factor C subunit 4. (363 aa)
CCDC174Coiled-coil domain-containing protein 174. (349 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
DSCC1Sister chromatid cohesion protein DCC1. (392 aa)
RFC2Replication factor C subunit 2 isoform X1. (368 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
GINS4DNA replication complex GINS protein SLD5. (162 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DCP2m7GpppN-mRNA hydrolase isoform X1. (422 aa)
LOC102730087Ceramide synthase 1-like. (99 aa)
LOC102744478Niban-like protein 1-like. (374 aa)
LOC102735621Cyclin-dependent kinase 1-like. (387 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
NEK2Serine/threonine-protein kinase Nek2. (259 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102747042DNA polymerase subunit gamma-2, mitochondrial-like. (220 aa)
LOC102730835T-complex protein 1 subunit beta-like. (535 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
ACDLOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse). (494 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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