STRINGSTRING
PARK7 PARK7 TGFB1 TGFB1 LOC102744478 LOC102744478 ZNF593 ZNF593 HEY2 HEY2 LOC102750316 LOC102750316 FBXW9 FBXW9 DDIT3 DDIT3 LOC102727186 LOC102727186 FBXW7 FBXW7 PAX6 PAX6 RNF220 RNF220 SRI SRI EP300 EP300 IGF1 IGF1 DDRGK1 DDRGK1 TRAF6 TRAF6 LOC102727212 LOC102727212 LOC102727215 LOC102727215 ZMPSTE24 ZMPSTE24 LOC102726510 LOC102726510 GATA1 GATA1 GTF2B GTF2B IFNG IFNG RB1 RB1 LOC102734590 LOC102734590 GATA3 GATA3 MSX1 MSX1 HAND1 HAND1 LHX2 LHX2 HEYL HEYL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARK7Protein DJ-1 isoform X1. (189 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102744478Niban-like protein 1-like. (374 aa)
ZNF593Zinc finger protein 593. (134 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2-like. (337 aa)
LOC102750316Hairy/enhancer-of-split related with YRPW motif protein 1-like isoform X2. (304 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
PAX6Paired box protein Pax-6. (221 aa)
RNF220E3 ubiquitin-protein ligase RNF220 isoform X1. (566 aa)
SRISorcin. (198 aa)
EP300Histone acetyltransferase p300. (2425 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC102727212Ankyrin repeat domain-containing protein 33B-like. (178 aa)
LOC102727215Niban-like protein 1-like. (398 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
LOC102726510Zinc finger C4H2 domain-containing protein-like isoform X1. (224 aa)
GATA1Erythroid transcription factor. (413 aa)
GTF2BTranscription initiation factor IIB. (316 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RB1Retinoblastoma-associated protein. (846 aa)
LOC102734590Ankyrin repeat domain-containing protein 33B-like. (378 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
MSX1Homeobox protein MSX-1. (303 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
LHX2LIM/homeobox protein Lhx2-like isoform X1. (406 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (328 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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