(16 nodes) Regulation of double-strand break repair via nonhomologous end joining network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARP3	Poly [ADP-ribose] polymerase. (532 aa)
	HMGA2	High mobility group protein HMGI-C. (109 aa)
	POT1	Protection of telomeres protein 1-like. (516 aa)
	ERCC6	DNA excision repair protein ERCC-6. (457 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa)
	DEK	Protein DEK. (314 aa)
	LOC102734598	Histone-lysine N-methyltransferase SUV420H1-like. (225 aa)
	NUDT16L1	Protein syndesmos isoform X2. (210 aa)
	SUV420H2	Histone-lysine N-methyltransferase SUV420H2. (461 aa)
	LOC102734738	Protein FAM35A-like. (222 aa)
	AUNIP	Aurora kinase A and ninein-interacting protein. (355 aa)
	HSF1	Heat shock factor protein 1. (527 aa)
	DTX3L	E3 ubiquitin-protein ligase DTX3L. (692 aa)
	SIRT7	NAD-dependent protein deacetylase sirtuin-7. (251 aa)
	LOC102735086	Uncharacterized protein C20orf196 homolog. (206 aa)
	WRAP53	Telomerase Cajal body protein 1. (532 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEK	ERCC6	A0A2U3X8H5	A0A2U3X9W2	Protein DEK.	DNA excision repair protein ERCC-6.	0.617
ERCC6	DEK	A0A2U3X9W2	A0A2U3X8H5	DNA excision repair protein ERCC-6.	Protein DEK.	0.617
LOC102734598	SUV420H2	A0A2U3YGA8	A0A2U3YY58	Histone-lysine N-methyltransferase SUV420H1-like.	Histone-lysine N-methyltransferase SUV420H2.	0.900
LOC102734738	LOC102735086	A0A2U3YXG3	A0A2U3XVR6	Protein FAM35A-like.	Uncharacterized protein C20orf196 homolog.	0.870
LOC102735086	LOC102734738	A0A2U3XVR6	A0A2U3YXG3	Uncharacterized protein C20orf196 homolog.	Protein FAM35A-like.	0.870
POT1	WRAP53	A0A2U3XCB6	A0A2U3Y5L0	Protection of telomeres protein 1-like.	Telomerase Cajal body protein 1.	0.695
SUV420H2	LOC102734598	A0A2U3YY58	A0A2U3YGA8	Histone-lysine N-methyltransferase SUV420H2.	Histone-lysine N-methyltransferase SUV420H1-like.	0.900
WRAP53	POT1	A0A2U3Y5L0	A0A2U3XCB6	Telomerase Cajal body protein 1.	Protection of telomeres protein 1-like.	0.695