(36 nodes) Positive regulation of intrinsic apoptotic signaling pathway network (Leptonychotes weddellii)

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Your Input:
	FBXW7	F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
	DNM1L	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	LOC102746429	Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (222 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	DFNA5	Non-syndromic hearing impairment protein 5. (214 aa)
	NKX3-1	Homeobox protein Nkx-3.1 isoform X1. (231 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	NUPR1	Nuclear protein 1 isoform X1. (82 aa)
	IL19	Interleukin-19. (177 aa)
	SERINC3	Serine incorporator 3. (473 aa)
	FBXO18	F-box only protein 18. (972 aa)
	IL20RA	Interleukin-20 receptor subunit alpha. (502 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (503 aa)
	BCLAF1	Bcl-2-associated transcription factor 1 isoform X1. (921 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	PLEKHF1	Pleckstrin homology domain-containing family F member 1. (277 aa)
	PLAGL2	Zinc finger protein PLAGL2. (496 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	NOX1	NADPH oxidase 1 isoform X1. (564 aa)
	NACC2	Nucleus accumbens-associated protein 2. (586 aa)
	FLCN	Folliculin. (579 aa)
	GNB2L1	Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
	PARK7	Protein DJ-1 isoform X1. (189 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (140 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
	LOC102729504	Apoptosis regulator BAX-like. (212 aa)
	FBXW9	F-box/WD repeat-containing protein 9. (458 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	BOK	Bcl-2-related ovarian killer protein. (213 aa)
	LOC102741358	Protein S100; Belongs to the S-100 family. (89 aa)
	LOC102734861	BH3-interacting domain death agonist-like. (83 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOK	DNM1L	A0A2U3Z482	A0A2U3X8D8	Bcl-2-related ovarian killer protein.	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.532
BOK	LOC102734861	A0A2U3Z482	A0A2U3Z8M2	Bcl-2-related ovarian killer protein.	BH3-interacting domain death agonist-like.	0.807
BOK	PARK7	A0A2U3Z482	A0A2U3YTX8	Bcl-2-related ovarian killer protein.	Protein DJ-1 isoform X1.	0.462
BOK	PMAIP1	A0A2U3Z482	A0A2U3XJD5	Bcl-2-related ovarian killer protein.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.656
CAV1	DNM1L	A0A2U3XCN0	A0A2U3X8D8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.461
DFNA5	FLCN	A0A2U3XDR5	A0A2U3YLS2	Non-syndromic hearing impairment protein 5.	Folliculin.	0.545
DNM1L	BOK	A0A2U3X8D8	A0A2U3Z482	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Bcl-2-related ovarian killer protein.	0.532
DNM1L	CAV1	A0A2U3X8D8	A0A2U3XCN0	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.461
DNM1L	FIS1	A0A2U3X8D8	A0A2U3XQQ5	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.858
FBXW7	TP53	A0A2U3X751	A0A2U3Y5G3	F-box/WD repeat-containing protein 7 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.674
FIS1	DNM1L	A0A2U3XQQ5	A0A2U3X8D8	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.858
FLCN	DFNA5	A0A2U3YLS2	A0A2U3XDR5	Folliculin.	Non-syndromic hearing impairment protein 5.	0.545
IL19	IL20RA	A0A2U3XRN1	A0A2U3XU39	Interleukin-19.	Interleukin-20 receptor subunit alpha.	0.948
IL20RA	IL19	A0A2U3XU39	A0A2U3XRN1	Interleukin-20 receptor subunit alpha.	Interleukin-19.	0.948
LOC102729504	LOC102734861	A0A2U3Z356	A0A2U3Z8M2	Apoptosis regulator BAX-like.	BH3-interacting domain death agonist-like.	0.996
LOC102729504	PMAIP1	A0A2U3Z356	A0A2U3XJD5	Apoptosis regulator BAX-like.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.616
LOC102729504	TP53	A0A2U3Z356	A0A2U3Y5G3	Apoptosis regulator BAX-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.931
LOC102734861	BOK	A0A2U3Z8M2	A0A2U3Z482	BH3-interacting domain death agonist-like.	Bcl-2-related ovarian killer protein.	0.807
LOC102734861	LOC102729504	A0A2U3Z8M2	A0A2U3Z356	BH3-interacting domain death agonist-like.	Apoptosis regulator BAX-like.	0.996
LOC102734861	PMAIP1	A0A2U3Z8M2	A0A2U3XJD5	BH3-interacting domain death agonist-like.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.911