(47 nodes) Negative regulation of chromosome organization network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC102730711	DNA replication licensing factor MCM2-like. (149 aa)
	ATRX	Transcriptional regulator ATRX isoform X1. (2489 aa)
	LOC102746922	Mitotic checkpoint protein BUB3-like. (142 aa)
	LOC102727565	Galactokinase-like. (208 aa)
	TEN1	CST complex subunit TEN1. (136 aa)
	ERCC4	DNA repair endonuclease XPF. (916 aa)
	KHDC3L	KHDC3-like protein. (235 aa)
	POT1	Protection of telomeres protein 1-like. (516 aa)
	ZWILCH	Protein zwilch homolog. (344 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	TERF2	Telomeric repeat-binding factor 2. (542 aa)
	PTTG1	Securin isoform X1. (201 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	TPR	Nucleoprotein TPR-like isoform X1. (2439 aa)
	LOC102731039	Histone H3.3-like. (128 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	LOC102731771	Telomeric repeat-binding factor 2-interacting protein 1-like. (122 aa)
	LOC102739980	F-box only protein 5-like. (228 aa)
	RAD21	Double-strand-break repair protein rad21 homolog. (631 aa)
	RAD50	DNA repair protein RAD50. (973 aa)
	SMARCA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa)
	ZW10	Centromere/kinetochore protein zw10 homolog. (779 aa)
	EXOSC10	Exosome component 10 isoform X1. (887 aa)
	AURKB	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (344 aa)
	CTC1	CST complex subunit CTC1. (1218 aa)
	ERCC1	DNA excision repair protein ERCC-1. (293 aa)
	TINF2	LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (481 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1328 aa)
	WAPAL	Wings apart-like protein homolog. (1154 aa)
	KNTC1	Kinetochore-associated protein 1. (2219 aa)
	LOC102738505	Inactive serine/threonine-protein kinase TEX14-like. (347 aa)
	PSMG2	Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (266 aa)
	BAZ1B	Tyrosine-protein kinase BAZ1B. (1443 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
	TRIP13	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (460 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1514 aa)
	GSG2	Serine/threonine-protein kinase haspin. (770 aa)
	LOC102732330	Histone H3; Belongs to the histone H3 family. (136 aa)
	DCP2	m7GpppN-mRNA hydrolase isoform X1. (422 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa)
	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (986 aa)
	LOC102730819	Histone H3; Belongs to the histone H3 family. (136 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	SMG6	Telomerase-binding protein EST1A. (711 aa)
	BIRC5	Baculoviral IAP repeat-containing protein 5. (74 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (265 aa)
	ACD	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse). (494 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	CTC1	A0A2U3ZA08	A0A2U3Y3T5	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	CST complex subunit CTC1.	0.575
ACD	LOC102731771	A0A2U3ZA08	A0A2U3XQK9	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	Telomeric repeat-binding factor 2-interacting protein 1-like.	0.993
ACD	POT1	A0A2U3ZA08	A0A2U3XCB6	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	Protection of telomeres protein 1-like.	0.999
ACD	TEN1	A0A2U3ZA08	A0A2U3X9F3	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	CST complex subunit TEN1.	0.682
ACD	TERF2	A0A2U3ZA08	A0A2U3XF72	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	Telomeric repeat-binding factor 2.	0.991
ACD	TINF2	A0A2U3ZA08	A0A2U3Y7P9	LOW QUALITY PROTEIN: adrenocortical dysplasia homolog (Mouse).	LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2.	0.999
AFMID	BIRC5	A0A2U3Z7X0	A0A2U3Z724	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Baculoviral IAP repeat-containing protein 5.	0.441
ATM	ATRX	A0A2U3YJR1	A0A2U3X662	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transcriptional regulator ATRX isoform X1.	0.640
ATM	ERCC1	A0A2U3YJR1	A0A2U3Y4P3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA excision repair protein ERCC-1.	0.632
ATM	ERCC4	A0A2U3YJR1	A0A2U3XB34	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair endonuclease XPF.	0.542
ATM	LOC102730819	A0A2U3YJR1	A0A2U3Z299	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.550
ATM	LOC102731039	A0A2U3YJR1	A0A2U3XLF3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3.3-like.	0.550
ATM	LOC102732330	A0A2U3YJR1	A0A2U3YTU8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.550
ATM	PLK1	A0A2U3YJR1	A0A2U3XHB0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase PLK.	0.491
ATM	RAD50	A0A2U3YJR1	A0A2U3XTH3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein RAD50.	0.989
ATM	TERF2	A0A2U3YJR1	A0A2U3XF72	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomeric repeat-binding factor 2.	0.428
ATM	TRIP13	A0A2U3YJR1	A0A2U3YNC0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.481
ATRX	ATM	A0A2U3X662	A0A2U3YJR1	Transcriptional regulator ATRX isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.640
ATRX	HNRNPU	A0A2U3X662	A0A2U3Z434	Transcriptional regulator ATRX isoform X1.	Heterogeneous nuclear ribonucleoprotein U isoform X1.	0.405
ATRX	LOC102730819	A0A2U3X662	A0A2U3Z299	Transcriptional regulator ATRX isoform X1.	Histone H3; Belongs to the histone H3 family.	0.553