(34 nodes) PML body network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	SUMO2	Small ubiquitin-related modifier. (95 aa)
	MLIP	mucin-5AC-like isoform X1. (993 aa)
	TP53INP1	Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
	TRIM8	Probable E3 ubiquitin-protein ligase TRIM8. (551 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ISG20	Interferon-stimulated gene 20 kDa protein. (171 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	ELF4	ETS-related transcription factor Elf-4. (657 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
	LOC102741681	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
	HIPK2	Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
	ZCCHC12	Zinc finger CCHC domain-containing protein 12. (402 aa)
	RNF111	E3 ubiquitin-protein ligase Arkadia isoform X1. (994 aa)
	ANKRD2	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2. (362 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	TDP2	tyrosyl-DNA phosphodiesterase 2. (358 aa)
	LOC102737595	Small ubiquitin-related modifier. (95 aa)
	PML	Protein PML. (880 aa)
	CALCOCO2	Calcium-binding and coiled-coil domain-containing protein 2 isoform X2. (449 aa)
	CHEK2	Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
	LOC102748381	Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
	ZMYM2	Zinc finger MYM-type protein 2. (1303 aa)
	MORC3	MORC family CW-type zinc finger protein 3. (900 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
	HSF1	Heat shock factor protein 1. (527 aa)
	SUMO3	Small ubiquitin-related modifier. (111 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	CASP8AP2	CASP8-associated protein 2. (1969 aa)
	LOC102747537	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (549 aa)
	RNF6	E3 ubiquitin-protein ligase RNF6 isoform X1. (683 aa)
	ZCCHC18	Putative zinc finger CCHC domain-containing protein 18. (403 aa)
	LRCH4	Leucine-rich repeat and calponin homology domain-containing protein 4-like. (685 aa)
	LOC102733867	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALCOCO2	LOC102748381	A0A2U3YCR1	A0A2U3YDT3	Calcium-binding and coiled-coil domain-containing protein 2 isoform X2.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like.	0.739
CHEK2	LOC102733867	A0A2U3YD03	A0A2U3Z7B1	Serine/threonine-protein kinase Chk2 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.697
CHEK2	PTEN	A0A2U3YD03	A0A2U3XMX7	Serine/threonine-protein kinase Chk2 isoform X1.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.452
CHEK2	TP53	A0A2U3YD03	A0A2U3Y5G3	Serine/threonine-protein kinase Chk2 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980
CHEK2	TP73	A0A2U3YD03	A0A2U3YWX9	Serine/threonine-protein kinase Chk2 isoform X1.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.697
HIPK2	LOC102737595	A0A2U3XWK9	A0A2U3Y8B4	Homeodomain-interacting protein kinase 2-like isoform X1.	Small ubiquitin-related modifier.	0.603
HIPK2	PML	A0A2U3XWK9	A0A2U3YBC0	Homeodomain-interacting protein kinase 2-like isoform X1.	Protein PML.	0.470
HIPK2	SUMO1	A0A2U3XWK9	A0A2U3XT97	Homeodomain-interacting protein kinase 2-like isoform X1.	Small ubiquitin-related modifier.	0.793
HIPK2	SUMO2	A0A2U3XWK9	A0A2U3X9G7	Homeodomain-interacting protein kinase 2-like isoform X1.	Small ubiquitin-related modifier.	0.603
HIPK2	SUMO3	A0A2U3XWK9	A0A2U3YTI9	Homeodomain-interacting protein kinase 2-like isoform X1.	Small ubiquitin-related modifier.	0.603
HIPK2	TP53	A0A2U3XWK9	A0A2U3Y5G3	Homeodomain-interacting protein kinase 2-like isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.987
HSF1	MAPK7	A0A2U3YRZ7	A0A2U3XK88	Heat shock factor protein 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.575
LOC102733867	CHEK2	A0A2U3Z7B1	A0A2U3YD03	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Serine/threonine-protein kinase Chk2 isoform X1.	0.697
LOC102733867	LOC102737595	A0A2U3Z7B1	A0A2U3Y8B4	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Small ubiquitin-related modifier.	0.400
LOC102733867	PTEN	A0A2U3Z7B1	A0A2U3XMX7	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.484
LOC102733867	SUMO1	A0A2U3Z7B1	A0A2U3XT97	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Small ubiquitin-related modifier.	0.400
LOC102733867	SUMO2	A0A2U3Z7B1	A0A2U3X9G7	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Small ubiquitin-related modifier.	0.400
LOC102733867	SUMO3	A0A2U3Z7B1	A0A2U3YTI9	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Small ubiquitin-related modifier.	0.400
LOC102733867	TP53	A0A2U3Z7B1	A0A2U3Y5G3	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.819
LOC102733867	TP53INP1	A0A2U3Z7B1	A0A2U3XEC8	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.416