(95 nodes) External encapsulating structure network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTHRC1	Collagen triple helix repeat-containing protein 1. (244 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	ST8SIA4	CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase; Belongs to the glycosyltransferase 29 family. (359 aa)
	TINAG	Tubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa)
	UCMA	Unique cartilage matrix-associated protein. (138 aa)
	LAMC1	Laminin subunit gamma-1. (1608 aa)
	ZPLD1	Zona pellucida-like domain-containing protein 1. (415 aa)
	COCH	Cochlin. (550 aa)
	IMPG1	LOW QUALITY PROTEIN: interphotoreceptor matrix proteoglycan 1. (785 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	PAPLN	Papilin. (1268 aa)
	SPOCK2	Testican-2 isoform X1. (424 aa)
	OPTC	Opticin. (327 aa)
	MFAP4	Microfibril-associated glycoprotein 4. (255 aa)
	CLEC7A	C-type lectin domain family 7 member A. (248 aa)
	ANXA2	Annexin. (339 aa)
	VWA1	Von Willebrand factor A domain-containing protein 1. (367 aa)
	COL4A1	Collagen alpha-1(IV) chain. (321 aa)
	LOC102728725	Glucose-fructose oxidoreductase domain-containing protein 1-like. (287 aa)
	ZP4	Zona pellucida sperm-binding protein 4 isoform X1. (574 aa)
	LOC102750614	Uncharacterized protein C2orf80 homolog. (197 aa)
	HPSE2	Inactive heparanase-2 isoform X1. (592 aa)
	COL26A1	Collagen alpha-1(XXVI) chain. (147 aa)
	PGM3	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (551 aa)
	RWDD2A	RWD domain-containing protein. (292 aa)
	CTXN1	Cortexin-1. (82 aa)
	TGFBR3L	LOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (292 aa)
	LOC102738390	Amelogenin, Y isoform-like. (317 aa)
	ZP3	Zona pellucida sperm-binding protein 3. (427 aa)
	POSTN	Periostin isoform X1. (836 aa)
	TECTA	Alpha-tectorin. (2155 aa)
	SMOC1	SPARC-related modular calcium-binding protein 1. (410 aa)
	BAG1	BAG family molecular chaperone regulator 1. (395 aa)
	FN1	Fibronectin isoform X1. (2476 aa)
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1 isoform X1. (502 aa)
	LTK	LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (841 aa)
	LOC102735869	Collagen alpha-5(IV) chain-like. (245 aa)
	MFAP2	Microfibrillar-associated protein 2. (183 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ZP2	Zona pellucida sperm-binding protein 2. (715 aa)
	ADAP2	arf-GAP with dual PH domain-containing protein 2. (385 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
	LTBP3	Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
	LEPREL1	Prolyl 3-hydroxylase 2. (533 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (369 aa)
	ALG11	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase. (492 aa)
	LOC102743414	Thrombospondin-2-like. (463 aa)
	LOC102750752	Lysyl oxidase homolog 2-like. (126 aa)
	ANGPT2	Angiopoietin-2 isoform X1. (495 aa)
	PMP22	Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
	COL4A4	Collagen alpha-4(IV) chain-like. (1589 aa)
	THBS1	Thrombospondin-1 isoform X1. (1170 aa)
	COL8A1	Collagen alpha-1(VIII) chain isoform X1. (744 aa)
	HSPA12B	Heat shock 70 kDa protein 12B isoform X1. (680 aa)
	CASC5	Protein CASC5. (2136 aa)
	ADNP2	ADNP homeobox protein 2-like. (1134 aa)
	TECTB	Beta-tectorin. (329 aa)
	PAQR4	Progestin and adipoQ receptor family member 4 isoform X1. (273 aa)
	ADAMTSL2	ADAMTS-like protein 2. (955 aa)
	LOC102733506	Latent-transforming growth factor beta-binding protein 1-like. (975 aa)
	OLFML2A	Olfactomedin-like protein 2A. (262 aa)
	TGFBI	Transforming growth factor-beta-induced protein ig-h3. (683 aa)
	SPARC	SPARC isoform X2. (304 aa)
	LTBP4	Latent-transforming growth factor beta-binding protein 4. (1519 aa)
	SERPINB12	Serpin B12 isoform X1; Belongs to the serpin family. (425 aa)
	COL6A2	Collagen alpha-2(VI) chain. (1021 aa)
	COL6A1	Collagen alpha-1(VI) chain. (1027 aa)
	NID1	Nidogen-1. (1241 aa)
	MMP11	Stromelysin-3. (489 aa)
	LOC102742539	Sushi, nidogen and EGF-like domain-containing protein 1-like. (377 aa)
	KERA	Keratocan. (350 aa)
	EPYC	Epiphycan. (321 aa)
	ADAMTS4	A disintegrin and metalloproteinase with thrombospondin motifs 4. (840 aa)
	LOC102748304	Splicing factor, suppressor of white-apricot homolog. (277 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SLC27A5	Bile acyl-CoA synthetase. (687 aa)
	MMRN2	Multimerin-2-like. (799 aa)
	COMP	Cartilage oligomeric matrix protein. (728 aa)
	EMID1	EMI domain-containing protein 1 isoform X1. (445 aa)
	FBLN2	Fibulin-2 isoform X1. (1228 aa)
	GFOD2	Glucose-fructose oxidoreductase domain-containing protein 2. (385 aa)
	SNED1	Sushi, nidogen and EGF-like domain-containing protein 1. (959 aa)
	LOC102729200	Collagen alpha-1(IV) chain-like. (863 aa)
	LOC102726566	Fibrillin-1-like. (1491 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (307 aa)
	MPV17	Protein Mpv17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
	LAMB2	Laminin subunit beta-2 isoform X1. (1801 aa)
	LOC102736544	Thrombospondin-4-like. (685 aa)
	GPC1	Glypican-1-like; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
	LOC102733453	A disintegrin and metalloproteinase with thrombospondin motifs 9-like. (231 aa)
	CILP	LOW QUALITY PROTEIN: cartilage intermediate layer protein 1. (1160 aa)
	LOC102732059	zf-CCHC_6 domain-containing protein. (462 aa)
	ADAMTS10	A disintegrin and metalloproteinase with thrombospondin motifs 10. (1103 aa)
	SHH	Sonic hedgehog protein-like. (286 aa)
	LOC102748835	Glucagon-like peptide 1 receptor-like; Belongs to the G-protein coupled receptor 2 family. (368 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS10	ADAMTSL2	A0A2U3Z547	A0A2U3YK08	A disintegrin and metalloproteinase with thrombospondin motifs 10.	ADAMTS-like protein 2.	0.422
ADAMTS10	LOC102726566	A0A2U3Z547	A0A2U3Z1B4	A disintegrin and metalloproteinase with thrombospondin motifs 10.	Fibrillin-1-like.	0.634
ADAMTS4	BGN	A0A2U3YUP3	A0A2U3Y9V6	A disintegrin and metalloproteinase with thrombospondin motifs 4.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.479
ADAMTS4	COMP	A0A2U3YUP3	A0A2U3YXU5	A disintegrin and metalloproteinase with thrombospondin motifs 4.	Cartilage oligomeric matrix protein.	0.506
ADAMTS4	LOC102733453	A0A2U3YUP3	A0A2U3Z4G1	A disintegrin and metalloproteinase with thrombospondin motifs 4.	A disintegrin and metalloproteinase with thrombospondin motifs 9-like.	0.898
ADAMTS4	LOC102736544	A0A2U3YUP3	A0A2U3Z3F7	A disintegrin and metalloproteinase with thrombospondin motifs 4.	Thrombospondin-4-like.	0.413
ADAMTSL2	ADAMTS10	A0A2U3YK08	A0A2U3Z547	ADAMTS-like protein 2.	A disintegrin and metalloproteinase with thrombospondin motifs 10.	0.422
ADAMTSL2	COL6A1	A0A2U3YK08	A0A2U3YQN6	ADAMTS-like protein 2.	Collagen alpha-1(VI) chain.	0.403
ADAMTSL2	LOC102726566	A0A2U3YK08	A0A2U3Z1B4	ADAMTS-like protein 2.	Fibrillin-1-like.	0.666
ADAMTSL2	LOC102733506	A0A2U3YK08	A0A2U3YKP7	ADAMTS-like protein 2.	Latent-transforming growth factor beta-binding protein 1-like.	0.683
ADAMTSL2	LTBP3	A0A2U3YK08	A0A2U3Y946	ADAMTS-like protein 2.	Latent-transforming growth factor beta-binding protein 3-like.	0.416
ALG11	PGM3	A0A2U3Y9Z9	A0A2U3XQY4	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase.	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.	0.798
ANGPT2	THBS1	A0A2U3YC09	A0A2U3YEE5	Angiopoietin-2 isoform X1.	Thrombospondin-1 isoform X1.	0.480
ANXA2	SPARC	A0A2U3XLQ6	A0A2U3YNL5	Annexin.	SPARC isoform X2.	0.437
BAG1	HSPA12B	A0A2U3XT89	A0A2U3YG02	BAG family molecular chaperone regulator 1.	Heat shock 70 kDa protein 12B isoform X1.	0.624
BGN	ADAMTS4	A0A2U3Y9V6	A0A2U3YUP3	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	A disintegrin and metalloproteinase with thrombospondin motifs 4.	0.479
BGN	COL6A1	A0A2U3Y9V6	A0A2U3YQN6	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-1(VI) chain.	0.603
BGN	COL6A2	A0A2U3Y9V6	A0A2U3YQ91	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-2(VI) chain.	0.681
BGN	COMP	A0A2U3Y9V6	A0A2U3YXU5	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Cartilage oligomeric matrix protein.	0.620
BGN	EPYC	A0A2U3Y9V6	A0A2U3YSY2	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Epiphycan.	0.478