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HCN4 HCN4 TRPC1 TRPC1 GRIK5 GRIK5 ATP1A3 ATP1A3 NDUFB11 NDUFB11 CPXM1 CPXM1 BEST3 BEST3 UBAC1 UBAC1 OSTM1 OSTM1 ATP1A4 ATP1A4 ATP1A2 ATP1A2 CACNA2D4 CACNA2D4 TRPC6 TRPC6 LOC102741857 LOC102741857 LOC102748316 LOC102748316 CHRNB4 CHRNB4 CATSPER4 CATSPER4 S100A12 S100A12 CHRNA2 CHRNA2 FXYD1 FXYD1 S100A9 S100A9 LOC102728180 LOC102728180 ABHD6 ABHD6 CNGA4 CNGA4 MPI MPI KCNQ4 KCNQ4 CHRNA10 CHRNA10 CNIH3 CNIH3 CACNG2 CACNG2 KCNMB3 KCNMB3 KCNMB2 KCNMB2 NDUFB5 NDUFB5 VWC2L VWC2L ABCD4 ABCD4 GRIN2D GRIN2D NIPAL3 NIPAL3 SCN4B SCN4B LRRIQ4 LRRIQ4 KCNH1 KCNH1 LRRC8E LRRC8E TRPC4 TRPC4 GRIK4 GRIK4 GRIN2A GRIN2A CHRNA9 CHRNA9 HCN3 HCN3 GABRG1 GABRG1 CATSPER2 CATSPER2 FKBP1A FKBP1A GRIK2 GRIK2 GRIN3A GRIN3A MICU2 MICU2 GABRB3 GABRB3 ABCC9 ABCC9 BEST4 BEST4 KCNA4 KCNA4 EN2 EN2 CACNB3 CACNB3 CACNG5 CACNG5 CACNG1 CACNG1 CACNG4 CACNG4 ATP7A ATP7A CNGB3 CNGB3 LOC102747789 LOC102747789 CLCN7 CLCN7 LRRC52 LRRC52 LOC102731583 LOC102731583 SCN2B SCN2B SLC43A2 SLC43A2 LOC102727336 LOC102727336 KCNH6 KCNH6 HCN2 HCN2 LRRC8D LRRC8D CACNA1G CACNA1G CHRNA7 CHRNA7 TRPC3 TRPC3 CNGA1 CNGA1 LOC102736905 LOC102736905 KCNG4 KCNG4 ATP1B1 ATP1B1 NDUFA9 NDUFA9 KCNA5 KCNA5 CATSPERB CATSPERB CHRNB1 CHRNB1 ATP4B ATP4B HSPA2 HSPA2 CLIC1 CLIC1 CACNA1F CACNA1F KCNH5 KCNH5 LOC102744643 LOC102744643 HTR3C HTR3C NDUFC1 NDUFC1 ATP1B3 ATP1B3 DLG3 DLG3 CLIC3 CLIC3 GRIN1 GRIN1 LRRC26 LRRC26 CACNG6 CACNG6 KCNE1L KCNE1L CACNG7 CACNG7 TMEM262 TMEM262 CLIC4 CLIC4 ATOX1 ATOX1 LOC102745974 LOC102745974 MCUR1 MCUR1 PDE4B PDE4B SCN9A SCN9A LOC102728737 LOC102728737 SCN2A SCN2A KCNIP1 KCNIP1 KCNH2 KCNH2 LOC102729172 LOC102729172 CACNA2D1 CACNA2D1 CCDC109B CCDC109B GABRA4 GABRA4 KCNIP4 KCNIP4 LOC102741278 LOC102741278 KCNJ5 KCNJ5 FOXRED1 FOXRED1 SCN10A SCN10A GLRB GLRB CCDC51 CCDC51 LOC102736350 LOC102736350 GRIA2 GRIA2 CARKD CARKD CHRNA6 CHRNA6 HTR3A HTR3A CHRNB3 CHRNB3 SLC31A1 SLC31A1 CHRNB2 CHRNB2 KCNMB4 KCNMB4 PDF PDF BEST2 BEST2 GABRG2 GABRG2 KCNJ11 KCNJ11 KCNA1 KCNA1 KCNK6 KCNK6 LOC102746549 LOC102746549 TTYH2 TTYH2 CNGA2 CNGA2 LOC102745857 LOC102745857 LOC102729628 LOC102729628 LRRC55 LRRC55 ABCG8 ABCG8 SCNN1B SCNN1B KCNG3 KCNG3 ABCB8 ABCB8 KCNIP2 KCNIP2 CATSPER3 CATSPER3 LRRC38 LRRC38
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (1039 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
GRIK5Glutamate receptor ionotropic, kainate 5. (624 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
NDUFB11NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial. (153 aa)
CPXM1Probable carboxypeptidase X1 isoform X1. (736 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (679 aa)
UBAC1Ubiquitin-associated domain-containing protein 1. (407 aa)
OSTM1Osteopetrosis-associated transmembrane protein 1. (334 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1102 aa)
TRPC6Short transient receptor potential channel 6-like isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
LOC102741857Chloride channel protein 1-like. (467 aa)
LOC102748316Cation channel sperm-associated protein subunit delta-like. (479 aa)
CHRNB4Neuronal acetylcholine receptor subunit beta-4. (498 aa)
CATSPER4Cation channel sperm-associated protein 4. (337 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
CHRNA2Neuronal acetylcholine receptor subunit alpha-2 isoform X1. (495 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
S100A9Protein S100; Belongs to the S-100 family. (140 aa)
LOC102728180Chloride channel protein. (524 aa)
ABHD6Monoacylglycerol lipase ABHD6. (337 aa)
CNGA4Cyclic nucleotide-gated cation channel alpha-4. (575 aa)
MPIMannose-6-phosphate isomerase. (421 aa)
KCNQ4Potassium voltage-gated channel subfamily KQT member 4; Belongs to the potassium channel family. (644 aa)
CHRNA10Neuronal acetylcholine receptor subunit alpha-10; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (286 aa)
CNIH3Protein cornichon homolog 3. (104 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (252 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (281 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
NDUFB5NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1. (189 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
ABCD4ATP-binding cassette sub-family D member 4. (606 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (840 aa)
NIPAL3NIPA-like protein 3. (407 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
LRRIQ4Leucine-rich repeat and IQ domain-containing protein 4. (553 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1-like. (638 aa)
LRRC8ELeucine-rich repeat-containing protein 8E. (793 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
GRIK4Glutamate receptor ionotropic, kainate 4. (956 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1308 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9. (479 aa)
HCN3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3. (782 aa)
GABRG1Gamma-aminobutyric acid receptor subunit gamma-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (472 aa)
CATSPER2Cation channel sperm-associated protein 2-like. (420 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
GRIK2Glutamate receptor ionotropic, kainate 2-like. (841 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A. (1115 aa)
MICU2Calcium uptake protein 2, mitochondrial isoform X1. (433 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (388 aa)
ABCC9ATP-binding cassette sub-family C member 9. (1461 aa)
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (473 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
EN2Homeobox protein engrailed-like. (224 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ATP7ACopper-transporting ATPase 1 isoform X1. (1498 aa)
CNGB3Cyclic nucleotide-gated cation channel beta-3. (780 aa)
LOC102747789NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like. (107 aa)
CLCN7Chloride channel protein. (809 aa)
LRRC52Leucine-rich repeat-containing protein 52. (315 aa)
LOC102731583Voltage-dependent calcium channel gamma-3 subunit-like. (315 aa)
SCN2BSodium channel subunit beta-2. (215 aa)
SLC43A2Large neutral amino acids transporter small subunit 4 isoform X1. (575 aa)
LOC102727336Voltage-dependent calcium channel subunit alpha-2/delta-3-like. (239 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6 isoform X1. (998 aa)
HCN2Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. (597 aa)
LRRC8DLeucine-rich repeat-containing protein 8D. (858 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7-like isoform X2. (499 aa)
TRPC3Short transient receptor potential channel 3-like. (592 aa)
CNGA1cGMP-gated cation channel alpha-1. (694 aa)
LOC102736905Glutamate receptor 3-like. (89 aa)
KCNG4Potassium voltage-gated channel subfamily G member 4; Belongs to the potassium channel family. (506 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (377 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
CATSPERBLOW QUALITY PROTEIN: cation channel sperm-associated protein subunit beta. (1066 aa)
CHRNB1Acetylcholine receptor subunit beta. (504 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
KCNH5Potassium voltage-gated channel subfamily H member 5-like. (921 aa)
LOC102744643Short transient receptor potential channel 3-like. (453 aa)
HTR3C5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
NDUFC1NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. (76 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (512 aa)
CLIC3Chloride intracellular channel protein 3. (237 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
LRRC26Leucine-rich repeat-containing protein 26. (304 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
KCNE1LPotassium voltage-gated channel subfamily E member 1-like protein. (141 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
TMEM262Transmembrane protein 262. (116 aa)
CLIC4Chloride intracellular channel protein 4. (135 aa)
ATOX1Copper transport protein ATOX1. (68 aa)
LOC102745974Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (239 aa)
MCUR1Mitochondrial calcium uniporter regulator 1. (172 aa)
PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4B. (284 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
LOC102728737Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1509 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
KCNIP1Kv channel-interacting protein 1 isoform X1. (227 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (819 aa)
LOC102729172NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like. (106 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1091 aa)
CCDC109BMitochondrial calcium uniporter regulatory subunit MCUb. (84 aa)
GABRA4Gamma-aminobutyric acid receptor subunit alpha-4 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (555 aa)
KCNIP4Kv channel-interacting protein 4. (186 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (430 aa)
FOXRED1FAD-dependent oxidoreductase domain-containing protein 1. (486 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
GLRBGlycine receptor subunit beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (305 aa)
CCDC51Coiled-coil domain-containing protein 51. (410 aa)
LOC102736350Potassium voltage-gated channel subfamily S member 3-like; Belongs to the potassium channel family. (491 aa)
GRIA2Glutamate receptor 2 isoform X1. (940 aa)
CARKDATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (346 aa)
CHRNA6Neuronal acetylcholine receptor subunit alpha-6 isoform X1. (493 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
CHRNB3Neuronal acetylcholine receptor subunit beta-3. (477 aa)
SLC31A1High affinity copper uptake protein 1. (178 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (510 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
PDFPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family. (182 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (508 aa)
GABRG2Gamma-aminobutyric acid receptor subunit gamma-2 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (390 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1-like; Belongs to the potassium channel family. (495 aa)
KCNK6Potassium channel subfamily K member. (313 aa)
LOC102746549Glutamate receptor ionotropic, NMDA 2C-like. (348 aa)
TTYH2Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (534 aa)
CNGA2Cyclic nucleotide-gated olfactory channel. (659 aa)
LOC102745857Phosphodiesterase. (503 aa)
LOC102729628Leucine-rich repeat-containing protein 8C-like. (756 aa)
LRRC55LOW QUALITY PROTEIN: leucine rich repeat containing 55. (268 aa)
ABCG8LOW QUALITY PROTEIN: ATP-binding cassette, sub-family G (WHITE), member 8. (519 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
KCNG3Potassium voltage-gated channel subfamily G member 3 isoform X1; Belongs to the potassium channel family. (436 aa)
ABCB8ATP-binding cassette sub-family B member 8, mitochondrial isoform X1. (713 aa)
KCNIP2Kv channel-interacting protein 2 isoform X2. (270 aa)
CATSPER3Cation channel sperm-associated protein 3. (415 aa)
LRRC38Leucine-rich repeat-containing protein 38. (216 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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