(115 nodes) EGF-like domain network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HYAL3	Hyaluronidase. (419 aa)
	TLL1	Metalloendopeptidase. (935 aa)
	MEP1A	Meprin A subunit. (720 aa)
	TMEFF1	Tomoregulin-1. (230 aa)
	TMEFF2	Tomoregulin-2-like isoform X1. (374 aa)
	FBN2	Fibrillin-2. (2952 aa)
	TGFA	Protransforming growth factor alpha. (160 aa)
	LAMC1	Laminin subunit gamma-1. (1608 aa)
	EREG	Proepiregulin. (292 aa)
	EPGN	Epigen isoform X1. (153 aa)
	LOC102741253	Amphiregulin-like. (253 aa)
	VWCE	Von Willebrand factor C and EGF domain-containing protein. (498 aa)
	NELL2	Protein kinase C-binding protein NELL2. (376 aa)
	HMCN1	Hemicentin-1-like. (5165 aa)
	PTGS2	Prostaglandin G/H synthase 2. (470 aa)
	OIT3	Oncoprotein-induced transcript 3 protein. (546 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	ADAM2	Disintegrin and metalloproteinase domain-containing protein 2. (731 aa)
	ADAM32	Disintegrin and metalloproteinase domain-containing protein 32. (721 aa)
	LOC102740164	Disintegrin and metalloproteinase domain-containing protein 18-like. (761 aa)
	ADAM18	Disintegrin and metalloproteinase domain-containing protein 18-like. (838 aa)
	WIF1	Wnt inhibitory factor 1. (379 aa)
	TMEM8A	Transmembrane protein 8A. (746 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	MFGE8	Lactadherin. (430 aa)
	LOC102731770	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like. (3146 aa)
	ZAN	Zonadhesin. (2627 aa)
	CUBN	Cubilin. (3065 aa)
	CRB1	Protein crumbs homolog 1 isoform X1. (1406 aa)
	EDIL3	EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1. (480 aa)
	LOC102735080	Disintegrin and metalloproteinase domain-containing protein 20-like. (662 aa)
	LOC102734779	Disintegrin and metalloproteinase domain-containing protein 20-like. (724 aa)
	NRG1	Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (694 aa)
	ADAM21	Disintegrin and metalloproteinase domain-containing protein 21. (720 aa)
	THBS3	Thrombospondin-3 isoform X1. (956 aa)
	ADAM15	Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (867 aa)
	MATN4	Matrilin-4 isoform X2. (583 aa)
	CRELD2	Cysteine-rich with EGF-like domain protein 2. (310 aa)
	MASP2	LOW QUALITY PROTEIN: mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family. (722 aa)
	TLL2	Metalloendopeptidase. (1182 aa)
	LOC102747961	Disintegrin and metalloproteinase domain-containing protein 1a-like. (758 aa)
	LOC102747671	Disintegrin and metalloproteinase domain-containing protein 1a-like. (741 aa)
	LOC102748855	Delta and Notch-like epidermal growth factor-related receptor-like. (297 aa)
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1 isoform X1. (502 aa)
	NOTCH4	Neurogenic locus notch homolog protein 4 isoform X1. (1996 aa)
	ATRNL1	Attractin-like protein 1-like. (1312 aa)
	DLK2	Protein delta homolog 2 isoform X1. (383 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	TEK	Angiopoietin-1 receptor isoform X1. (1125 aa)
	PYGM	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (625 aa)
	LOC102729648	Teratocarcinoma-derived growth factor 1-like. (184 aa)
	FBLN7	Fibulin-7. (384 aa)
	C1R	Complement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (705 aa)
	TENM1	Teneurin-1-like. (2582 aa)
	EGFL8	Epidermal growth factor-like protein 8. (304 aa)
	GAS6	Growth arrest-specific protein 6. (646 aa)
	SELE	E-selectin. (609 aa)
	LOC102728750	L-selectin-like. (166 aa)
	EFEMP2	EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
	LTBP3	Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
	CD248	Endosialin. (774 aa)
	STAB2	Stabilin-2. (335 aa)
	DNER	Delta and Notch-like epidermal growth factor-related receptor. (448 aa)
	THBD	Thrombomodulin. (577 aa)
	CD93	Complement component C1q receptor. (655 aa)
	LOC102738003	Protein kinase C-binding protein NELL2-like. (354 aa)
	MASP1	Mannan-binding lectin serine protease 1 isoform X1; Belongs to the peptidase S1 family. (728 aa)
	FAT1	Protocadherin Fat 1. (4345 aa)
	THBS1	Thrombospondin-1 isoform X1. (1170 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	F9	Coagulation factor IX isoform X1. (459 aa)
	LOC102750957	Cadherin EGF LAG seven-pass G-type receptor 2-like. (2324 aa)
	LOC102733601	Protein kinase C-binding protein NELL1-like. (424 aa)
	VWA2	Von Willebrand factor A domain-containing protein 2. (804 aa)
	LOC102749183	Fibulin-1-like. (624 aa)
	ATRAID	All-trans retinoic acid-induced differentiation factor. (229 aa)
	TMEM8B	Transmembrane protein 8B. (472 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (560 aa)
	HHIP	Hedgehog-interacting protein-like. (662 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (418 aa)
	LOC102733506	Latent-transforming growth factor beta-binding protein 1-like. (975 aa)
	BCAN	Brevican core protein. (912 aa)
	LDLR	Low-density lipoprotein receptor. (861 aa)
	PEAR1	Platelet endothelial aggregation receptor 1-like. (389 aa)
	HABP2	Hyaluronan-binding protein 2. (558 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	SUSD1	Sushi domain-containing protein 1. (716 aa)
	EGFL7	Epidermal growth factor-like protein 7. (274 aa)
	LTBP4	Latent-transforming growth factor beta-binding protein 4. (1519 aa)
	NRXN2	Neurexin-2. (1027 aa)
	LOC102737025	Signal peptide, CUB and EGF-like domain-containing protein 1-like. (182 aa)
	NID1	Nidogen-1. (1241 aa)
	LOC102742539	Sushi, nidogen and EGF-like domain-containing protein 1-like. (377 aa)
	LOC102742627	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like. (319 aa)
	MEGF9	Multiple epidermal growth factor-like domains protein 9. (610 aa)
	CLEC18A	C-type lectin domain family 18 member A-like isoform X1. (451 aa)
	EGFL6	Epidermal growth factor-like protein 6. (554 aa)
	ADAM30	Disintegrin and metalloproteinase domain-containing protein 30. (734 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (1238 aa)
	MEGF8	Multiple epidermal growth factor-like domains protein 8. (2068 aa)
	COMP	Cartilage oligomeric matrix protein. (728 aa)
	FBLN2	Fibulin-2 isoform X1. (1228 aa)
	LOC102727365	Platelet endothelial aggregation receptor 1-like. (677 aa)
	SNED1	Sushi, nidogen and EGF-like domain-containing protein 1. (959 aa)
	LOC102726566	Fibrillin-1-like. (1491 aa)
	LAMB2	Laminin subunit beta-2 isoform X1. (1801 aa)
	LAMA5	Laminin subunit alpha-5-like. (1341 aa)
	LOC102736544	Thrombospondin-4-like. (685 aa)
	CNTNAP1	Contactin-associated protein 1. (1385 aa)
	LOC102750700	Disintegrin and metalloproteinase domain-containing protein 21-like. (745 aa)
	LOC102736444	Uromodulin-like. (600 aa)
	LOC102747049	Signal peptide, CUB and EGF-like domain-containing protein 3-like. (624 aa)
	TIE1	Tyrosine-protein kinase receptor Tie-1. (1015 aa)
	VASN	Vasorin. (676 aa)
	LOC102733272	Cartilage matrix protein-like. (279 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM2	ADAM21	A0A2U3XK69	A0A2U3XSY8	Disintegrin and metalloproteinase domain-containing protein 2.	Disintegrin and metalloproteinase domain-containing protein 21.	0.866
ADAM2	ADAM30	A0A2U3XK69	A0A2U3YXQ4	Disintegrin and metalloproteinase domain-containing protein 2.	Disintegrin and metalloproteinase domain-containing protein 30.	0.964
ADAM2	LOC102734779	A0A2U3XK69	A0A2U3XSV3	Disintegrin and metalloproteinase domain-containing protein 2.	Disintegrin and metalloproteinase domain-containing protein 20-like.	0.869
ADAM21	ADAM2	A0A2U3XSY8	A0A2U3XK69	Disintegrin and metalloproteinase domain-containing protein 21.	Disintegrin and metalloproteinase domain-containing protein 2.	0.866
ADAM21	ADAM30	A0A2U3XSY8	A0A2U3YXQ4	Disintegrin and metalloproteinase domain-containing protein 21.	Disintegrin and metalloproteinase domain-containing protein 30.	0.847
ADAM21	LOC102734779	A0A2U3XSY8	A0A2U3XSV3	Disintegrin and metalloproteinase domain-containing protein 21.	Disintegrin and metalloproteinase domain-containing protein 20-like.	0.819
ADAM30	ADAM2	A0A2U3YXQ4	A0A2U3XK69	Disintegrin and metalloproteinase domain-containing protein 30.	Disintegrin and metalloproteinase domain-containing protein 2.	0.964
ADAM30	ADAM21	A0A2U3YXQ4	A0A2U3XSY8	Disintegrin and metalloproteinase domain-containing protein 30.	Disintegrin and metalloproteinase domain-containing protein 21.	0.847
ADAM30	LOC102734779	A0A2U3YXQ4	A0A2U3XSV3	Disintegrin and metalloproteinase domain-containing protein 30.	Disintegrin and metalloproteinase domain-containing protein 20-like.	0.848
ADAM30	NOTCH2	A0A2U3YXQ4	A0A2U3YXQ8	Disintegrin and metalloproteinase domain-containing protein 30.	Neurogenic locus notch homolog protein 2.	0.553
BCAN	FBN2	A0A2U3YKR2	A0A2U3X8X9	Brevican core protein.	Fibrillin-2.	0.408
BCAN	LOC102749183	A0A2U3YKR2	A0A2U3YIL9	Brevican core protein.	Fibulin-1-like.	0.447
COMP	LOC102733272	A0A2U3YXU5	A0A2U3Z766	Cartilage oligomeric matrix protein.	Cartilage matrix protein-like.	0.451
COMP	MATN4	A0A2U3YXU5	A0A2U3XV51	Cartilage oligomeric matrix protein.	Matrilin-4 isoform X2.	0.829
COMP	THBS1	A0A2U3YXU5	A0A2U3YEE5	Cartilage oligomeric matrix protein.	Thrombospondin-1 isoform X1.	0.563
COMP	THBS3	A0A2U3YXU5	A0A2U3XTR7	Cartilage oligomeric matrix protein.	Thrombospondin-3 isoform X1.	0.840
CUBN	LOC102736444	A0A2U3XRG8	A0A2U3Z597	Cubilin.	Uromodulin-like.	0.466
CUBN	LRP6	A0A2U3XRG8	A0A2U3XNU0	Cubilin.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.406
DLK2	EGFL6	A0A2U3XZ44	A0A2U3YVX2	Protein delta homolog 2 isoform X1.	Epidermal growth factor-like protein 6.	0.439
DLK2	EGFL8	A0A2U3XZ44	A0A2U3Y441	Protein delta homolog 2 isoform X1.	Epidermal growth factor-like protein 8.	0.451