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RASA4 RASA4 LOC102727193 LOC102727193 LOC102738669 LOC102738669 EXOC8 EXOC8 SPTBN1 SPTBN1 LOC102731954 LOC102731954 LOC102728301 LOC102728301 PLEKHG3 PLEKHG3 LOC102742564 LOC102742564 ARHGAP25 ARHGAP25 ARAP3 ARAP3 PLCL2 PLCL2 LOC102736541 LOC102736541 AGAP1 AGAP1 LOC102727172 LOC102727172 FERMT1 FERMT1 GAB2 GAB2 PLEKHM2 PLEKHM2 STAP2 STAP2 OSBP OSBP ARHGEF16 ARHGEF16 DOK4 DOK4 DGKH DGKH PSD4 PSD4 ARHGEF39 ARHGEF39 PLEKHA4 PLEKHA4 LOC102730084 LOC102730084 LOC102727869 LOC102727869 CYTH3 CYTH3 GRB7 GRB7 PLEKHH2 PLEKHH2 KIF1B KIF1B KIF1A KIF1A CNKSR1 CNKSR1 VAV2 VAV2 RASGRF1 RASGRF1 LOC102742229 LOC102742229 SPTBN4 SPTBN4 TTC9B TTC9B CYTH2 CYTH2 LOC102742125 LOC102742125 ARHGEF6 ARHGEF6 DOK2 DOK2 ITSN2 ITSN2 LOC102735415 LOC102735415 DNM1 DNM1 TIAM1 TIAM1 ADRBK1 ADRBK1 PLD2 PLD2 RTKN2 RTKN2 PLEKHA7 PLEKHA7 CYTH4 CYTH4 PHLDA3 PHLDA3 PLD1 PLD1 RASAL2 RASAL2 FGD6 FGD6 PHLDB1 PHLDB1 ELMO3 ELMO3 LOC102740305 LOC102740305 TEC TEC ARHGEF7 ARHGEF7 ARHGAP20 ARHGAP20 AGAP2 AGAP2 ARHGAP9 ARHGAP9 AKT3 AKT3 ELMO2 ELMO2 PLEKHF1 PLEKHF1 ADAP2 ADAP2 ACAP1 ACAP1 RASA3 RASA3 PLEKHH1 PLEKHH1 PLEKHH3 PLEKHH3 OSBPL11 OSBPL11 AKT1 AKT1 LOC102750823 LOC102750823 SYNGAP1 SYNGAP1 LOC102737498 LOC102737498 ARHGEF9 ARHGEF9 PLEKHA5 PLEKHA5 PHLDA1 PHLDA1 OSBPL8 OSBPL8 BTK BTK ASAP3 ASAP3 DNM3 DNM3 PRKD3 PRKD3 CDC42BPG CDC42BPG LOC102735275 LOC102735275 RALGPS1 RALGPS1 GAB3 GAB3 PLEKHA8 PLEKHA8 ARHGEF28 ARHGEF28 VAV3 VAV3 LOC102750052 LOC102750052 LOC102732879 LOC102732879 OSBPL5 OSBPL5 PHLDA2 PHLDA2 DOK1 DOK1 GRB10 GRB10 AFAP1 AFAP1 LOC102737884 LOC102737884 PLEKHG6 PLEKHG6 PLCD3 PLCD3 PLEKHD1 PLEKHD1 IRS1 IRS1 FERMT2 FERMT2 PREX1 PREX1 LOC102750621 LOC102750621 RTKN RTKN COL4A3BP COL4A3BP GAB1 GAB1 PLEKHO2 PLEKHO2 NET1 NET1 ABR ABR LOC102735079 LOC102735079 PLEKHA1 PLEKHA1 SH2B1 SH2B1 PSD3 PSD3 LOC102728010 LOC102728010 OSBPL6 OSBPL6 PLEKHA3 PLEKHA3 ANLN ANLN DOK3 DOK3 LOC102734862 LOC102734862 ACAP3 ACAP3 PHLDB3 PHLDB3 ARHGEF1 ARHGEF1 SKAP2 SKAP2 PSD2 PSD2 ARHGAP42 ARHGAP42 ITK ITK PLEKHB1 PLEKHB1 ARAP1 ARAP1 FGD1 FGD1 PLEK PLEK PLEKHF2 PLEKHF2 ARHGAP24 ARHGAP24 STAP1 STAP1 PLCH1 PLCH1 LOC102744083 LOC102744083 SWAP70 SWAP70 PLCL1 PLCL1 RASA1 RASA1 FGD4 FGD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASA4Ras GTPase-activating protein 4 isoform X1. (801 aa)
LOC102727193Pleckstrin homology domain-containing family A member 2-like. (196 aa)
LOC102738669Sesquipedalian-1-like. (141 aa)
EXOC8Exocyst complex component 8. (725 aa)
SPTBN1Spectrin beta chain, non-erythrocytic 1-like. (780 aa)
LOC102731954Rho guanine nucleotide exchange factor 19-like. (423 aa)
LOC102728301PH and SEC7 domain-containing protein 1-like. (393 aa)
PLEKHG3Pleckstrin homology domain-containing family G member 3. (1216 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
ARHGAP25Rho GTPase-activating protein 25-like. (557 aa)
ARAP3arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3. (1542 aa)
PLCL2Phosphoinositide phospholipase C. (909 aa)
LOC102736541Cytohesin-1-like. (251 aa)
AGAP1arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1. (248 aa)
LOC102727172Engulfment and cell motility protein 1-like. (247 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
PLEKHM2Pleckstrin homology domain-containing family M member 2. (1010 aa)
STAP2Signal-transducing adaptor protein 2. (411 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (491 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (709 aa)
DOK4Docking protein 4. (326 aa)
DGKHDiacylglycerol kinase. (1084 aa)
PSD4PH and SEC7 domain-containing protein 4. (1012 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
PLEKHA4Pleckstrin homology domain-containing family A member 4. (777 aa)
LOC102730084Growth factor receptor-bound protein 14-like. (226 aa)
LOC102727869Ras-associated and pleckstrin homology domains-containing protein 1-like isoform X1. (600 aa)
CYTH3Cytohesin-3. (270 aa)
GRB7Growth factor receptor-bound protein 7. (403 aa)
PLEKHH2Pleckstrin homology domain-containing family H member 2. (1493 aa)
KIF1BKinesin-like protein KIF1B. (593 aa)
KIF1AKinesin-like protein KIF1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1785 aa)
CNKSR1Connector enhancer of kinase suppressor of ras 1. (714 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1. (1165 aa)
LOC102742229Connector enhancer of kinase suppressor of ras 2-like. (576 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2419 aa)
TTC9BTetratricopeptide repeat protein 9B. (312 aa)
CYTH2Cytohesin-2 isoform X1. (399 aa)
LOC102742125TBC1 domain family member 2A-like. (698 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (508 aa)
DOK2Docking protein 2. (412 aa)
ITSN2Intersectin-2. (357 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
DNM1Dynamin-1 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
PLD2Phospholipase. (933 aa)
RTKN2Rhotekin-2. (608 aa)
PLEKHA7Pleckstrin homology domain-containing family A member 7. (701 aa)
CYTH4Cytohesin-4. (394 aa)
PHLDA3Pleckstrin homology-like domain family A member 3. (125 aa)
PLD1Phospholipase. (1074 aa)
RASAL2Ras GTPase-activating protein nGAP isoform X1. (1287 aa)
FGD6FYVE, RhoGEF and PH domain-containing protein 6. (1424 aa)
PHLDB1Pleckstrin homology-like domain family B member 1. (1381 aa)
ELMO3Engulfment and cell motility protein 3. (720 aa)
LOC1027403051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like. (211 aa)
TECTyrosine-protein kinase. (630 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (625 aa)
ARHGAP20Rho GTPase-activating protein 20-like. (1109 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1189 aa)
ARHGAP9Rho GTPase-activating protein 9. (741 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
ELMO2Engulfment and cell motility protein 2. (377 aa)
PLEKHF1Pleckstrin homology domain-containing family F member 1. (277 aa)
ADAP2arf-GAP with dual PH domain-containing protein 2. (385 aa)
ACAP1arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1. (740 aa)
RASA3Ras GTPase-activating protein 3. (834 aa)
PLEKHH1Pleckstrin homology domain-containing family H member 1. (1365 aa)
PLEKHH3Pleckstrin homology domain-containing family H member 3. (728 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (758 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
LOC102750823Spermatogenesis-associated protein 13-like. (1246 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP. (1228 aa)
LOC102737498Sesquipedalian-1-like. (205 aa)
ARHGEF9Rho guanine nucleotide exchange factor 9 isoform X1. (516 aa)
PLEKHA5Pleckstrin homology domain-containing family A member 5 isoform X2. (1118 aa)
PHLDA1Pleckstrin homology-like domain family A member 1. (385 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
BTKTyrosine-protein kinase. (659 aa)
ASAP3LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3. (902 aa)
DNM3Dynamin-3 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (865 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
CDC42BPGSerine/threonine-protein kinase MRCK gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
LOC102735275FYVE, RhoGEF and PH domain-containing protein 5-like. (596 aa)
RALGPS1Ras-specific guanine nucleotide-releasing factor RalGPS1. (426 aa)
GAB3GRB2-associated-binding protein 3. (507 aa)
PLEKHA8Pleckstrin homology domain-containing family A member 8. (520 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1389 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
LOC102750052SH3 domain-binding protein 2-like. (220 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
OSBPL5Oxysterol-binding protein; Belongs to the OSBP family. (891 aa)
PHLDA2Pleckstrin homology-like domain family A member 2. (138 aa)
DOK1Docking protein 1 isoform X1. (483 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
AFAP1Actin filament-associated protein 1 isoform X2. (729 aa)
LOC102737884Tyrosine-protein kinase. (539 aa)
PLEKHG6Pleckstrin homology domain-containing family G member 6. (790 aa)
PLCD3Phosphoinositide phospholipase C. (778 aa)
PLEKHD1Pleckstrin homology domain-containing family D member 1. (506 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
FERMT2Fermitin family homolog 2 isoform X1. (687 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1642 aa)
LOC102750621Oligophrenin-1-like. (685 aa)
RTKNRhotekin isoform X1. (564 aa)
COL4A3BPCollagen type IV alpha-3-binding protein. (405 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
PLEKHO2Pleckstrin homology domain-containing family O member 2. (498 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X1. (596 aa)
ABRActive breakpoint cluster region-related protein isoform X1. (871 aa)
LOC102735079Rho guanine nucleotide exchange factor 12-like. (163 aa)
PLEKHA1Pleckstrin homology domain-containing family A member 1 isoform X2. (335 aa)
SH2B1SH2B adapter protein 1 isoform X3. (688 aa)
PSD3PH and SEC7 domain-containing protein 3. (974 aa)
LOC102728010LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 3-like. (525 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (959 aa)
PLEKHA3Pleckstrin homology domain-containing family A member 3. (300 aa)
ANLNActin-binding protein anillin isoform X1. (1087 aa)
DOK3Docking protein 3. (447 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ACAP3arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3. (833 aa)
PHLDB3Pleckstrin homology-like domain family B member 3. (659 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (912 aa)
SKAP2Src kinase-associated phosphoprotein 2. (359 aa)
PSD2PH and SEC7 domain-containing protein 2-like. (350 aa)
ARHGAP42Rho GTPase-activating protein 42. (874 aa)
ITKTyrosine-protein kinase. (486 aa)
PLEKHB1Pleckstrin homology domain-containing family B member 1 isoform X1. (243 aa)
ARAP1arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1. (1459 aa)
FGD1FYVE, RhoGEF and PH domain-containing protein 1. (960 aa)
PLEKPleckstrin isoform X1. (350 aa)
PLEKHF2Pleckstrin homology domain-containing family F member 2-like. (249 aa)
ARHGAP24Rho GTPase-activating protein 24 isoform X1. (750 aa)
STAP1Signal-transducing adaptor protein 1. (332 aa)
PLCH1Phosphoinositide phospholipase C. (1675 aa)
LOC102744083Pleckstrin homology domain-containing family B member 2-like isoform X4. (222 aa)
SWAP70Switch-associated protein 70 isoform X1. (585 aa)
PLCL1Phosphoinositide phospholipase C. (1096 aa)
RASA1Ras GTPase-activating protein 1. (1039 aa)
FGD4FYVE, RhoGEF and PH domain-containing protein 4. (723 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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