(33 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	TBX3	T-box transcription factor TBX3. (675 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	MGA	MAX gene-associated protein isoform X1. (3064 aa)
	TBR1	T-box brain protein 1. (682 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (517 aa)
	TBX20	T-box transcription factor TBX20. (447 aa)
	TBX6	T-box transcription factor TBX6. (436 aa)
	REL	Proto-oncogene c-Rel. (594 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	MYRFL	Myelin regulatory factor-like protein. (909 aa)
	T	Brachyury protein isoform X1. (435 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
	NFAT5	Nuclear factor of activated T-cells 5 isoform X1. (1545 aa)
	TBX18	T-box transcription factor TBX18. (612 aa)
	TBX22	T-box transcription factor TBX22. (523 aa)
	STAT2	Signal transducer and activator of transcription. (854 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	TBX4	T-box transcription factor TBX4. (413 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	LOC102726972	T-box transcription factor TBX19-like. (173 aa)
	LOC102742062	T-box transcription factor TBX5-like. (308 aa)
	EOMES	Eomesodermin homolog isoform X2. (571 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	RUNX3	Runt-related transcription factor 3-like. (283 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	LOC102733867	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	TBX1	T-box transcription factor TBX1-like. (392 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EOMES	LOC102726972	A0A2U3YA50	A0A2U3YYV4	Eomesodermin homolog isoform X2.	T-box transcription factor TBX19-like.	0.496
EOMES	RUNX3	A0A2U3YA50	A0A2U3Z4P2	Eomesodermin homolog isoform X2.	Runt-related transcription factor 3-like.	0.612
EOMES	T	A0A2U3YA50	A0A2U3XGU5	Eomesodermin homolog isoform X2.	Brachyury protein isoform X1.	0.531
EOMES	TBX21	A0A2U3YA50	A0A2U3YMK5	Eomesodermin homolog isoform X2.	T-box transcription factor TBX21.	0.476
LOC102725943	NFATC1	A0A2U3YQY8	A0A2U3YQR5	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Nuclear factor of activated T-cells, cytoplasmic 1.	0.923
LOC102725943	NFATC3	A0A2U3YQY8	A0A2U3XF88	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.915
LOC102726972	EOMES	A0A2U3YYV4	A0A2U3YA50	T-box transcription factor TBX19-like.	Eomesodermin homolog isoform X2.	0.496
LOC102726972	RUNX3	A0A2U3YYV4	A0A2U3Z4P2	T-box transcription factor TBX19-like.	Runt-related transcription factor 3-like.	0.450
LOC102731864	LOC102745161	A0A2U3Z7Y1	A0A2U3Y4I5	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 3-like.	0.869
LOC102731864	STAT2	A0A2U3Z7Y1	A0A2U3YBI2	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription.	0.892
LOC102731864	STAT3	A0A2U3Z7Y1	A0A2U3Z463	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 3-like.	0.852
LOC102731864	STAT5A	A0A2U3Z7Y1	A0A2U3Z446	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5A.	0.948
LOC102731864	STAT5B	A0A2U3Z7Y1	A0A2U3Y4J7	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5B.	0.947
LOC102733867	RUNX3	A0A2U3Z7B1	A0A2U3Z4P2	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Runt-related transcription factor 3-like.	0.444
LOC102733867	TP53	A0A2U3Z7B1	A0A2U3Y5G3	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.819
LOC102733867	TP73	A0A2U3Z7B1	A0A2U3YWX9	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.986
LOC102745161	LOC102731864	A0A2U3Y4I5	A0A2U3Z7Y1	Signal transducer and activator of transcription 3-like.	Signal transducer and activator of transcription 5B-like.	0.869
LOC102745161	NFKB1	A0A2U3Y4I5	A0A2U3XMD9	Signal transducer and activator of transcription 3-like.	Nuclear factor NF-kappa-B p105 subunit.	0.454
LOC102745161	STAT2	A0A2U3Y4I5	A0A2U3YBI2	Signal transducer and activator of transcription 3-like.	Signal transducer and activator of transcription.	0.904
LOC102745161	STAT3	A0A2U3Y4I5	A0A2U3Z463	Signal transducer and activator of transcription 3-like.	Signal transducer and activator of transcription 3-like.	0.950