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RARS2 RARS2 GCAT GCAT ACSS1 ACSS1 LARS2 LARS2 ACSL3 ACSL3 RARS RARS PIAS2 PIAS2 MDM2 MDM2 MTHFS MTHFS SARS2 SARS2 PIAS4 PIAS4 VARS VARS MUL1 MUL1 SUCLA2 SUCLA2 TTL TTL ACSL4 ACSL4 RTCB RTCB LOC102746877 LOC102746877 EGR2 EGR2 LOC102741787 LOC102741787 RLIM RLIM TARS TARS LARS LARS LOC102747174 LOC102747174 LOC102739874 LOC102739874 TTLL12 TTLL12 WARS2 WARS2 UBA1 UBA1 PCCA PCCA HLCS HLCS ACSL5 ACSL5 SARS SARS PPCS PPCS KARS KARS FPGS FPGS ACSL1 ACSL1 EPRS EPRS IARS2 IARS2 GCLC GCLC GATC GATC VARS2 VARS2 NAPRT1 NAPRT1 ADSS ADSS HARS HARS HARS2 HARS2 EARS2 EARS2 UBE3C UBE3C FARSA FARSA LOC102729201 LOC102729201 UFL1 UFL1 YARS2 YARS2 MARS2 MARS2 TARS2 TARS2 RANBP2 RANBP2 RNF220 RNF220 GLUL GLUL PIAS3 PIAS3 UBE3A UBE3A LIG4 LIG4 TTLL10 TTLL10 LOC102748344 LOC102748344 LOC102732165 LOC102732165 MARS MARS QARS QARS RNF6 RNF6 ACSBG2 ACSBG2 PIAS1 PIAS1 LOC102737445 LOC102737445 LOC102748619 LOC102748619 AARS2 AARS2 NARS2 NARS2 TRIM32 TRIM32 PET112 PET112 LOC102730690 LOC102730690
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RARS2Probable arginine--tRNA ligase, mitochondrial isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (578 aa)
GCAT2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial. (419 aa)
ACSS1Acetyl-coenzyme A synthetase. (614 aa)
LARS2Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (664 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
RARSarginine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (667 aa)
PIAS2E3 SUMO-protein ligase PIAS2-like. (612 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (202 aa)
SARS2serine--tRNA ligase, mitochondrial. (518 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (503 aa)
VARSvaline--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1264 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
TTLTubulin--tyrosine ligase. (377 aa)
ACSL4long-chain-fatty-acid--CoA ligase 4. (711 aa)
RTCBtRNA-splicing ligase RtcB homolog. (436 aa)
LOC102746877prolyl-tRNA synthetase associated domain-containing protein 1-like isoform X1. (172 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
LOC102741787aspartate--tRNA ligase, mitochondrial-like. (401 aa)
RLIME3 ubiquitin-protein ligase RLIM isoform X3. (625 aa)
TARSthreonine--tRNA ligase, cytoplasmic isoform X1. (723 aa)
LARSleucine--tRNA ligase, cytoplasmic isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa)
LOC102747174aspartate--tRNA ligase, mitochondrial-like. (278 aa)
LOC102739874cysteine--tRNA ligase, mitochondrial-like. (559 aa)
TTLL12Tubulin--tyrosine ligase-like protein 12. (645 aa)
WARS2tryptophan--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1 isoform X1; Belongs to the ubiquitin-activating E1 family. (1058 aa)
PCCApropionyl-CoA carboxylase alpha chain, mitochondrial. (674 aa)
HLCSBiotin--protein ligase. (678 aa)
ACSL5long-chain-fatty-acid--CoA ligase 5 isoform X2. (683 aa)
SARSserine--tRNA ligase, cytoplasmic. (265 aa)
PPCSPhosphopantothenate--cysteine ligase isoform X1. (310 aa)
KARSLysine--tRNA ligase. (625 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
ACSL1long-chain-fatty-acid--CoA ligase 1 isoform X1. (686 aa)
EPRSBifunctional glutamate/proline--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (974 aa)
IARS2isoleucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1012 aa)
GCLCGlutamate--cysteine ligase catalytic subunit-like isoform X1. (637 aa)
GATCGlutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (136 aa)
VARS2valine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1062 aa)
NAPRT1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (538 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
HARShistidine--tRNA ligase, cytoplasmic isoform X1. (509 aa)
HARS2Probable histidine--tRNA ligase, mitochondrial isoform X2. (505 aa)
EARS2Probable glutamate--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (523 aa)
UBE3CUbiquitin-protein ligase E3C. (1058 aa)
FARSAphenylalanine--tRNA ligase alpha subunit. (508 aa)
LOC102729201Diphthine--ammonia ligase-like isoform X1. (170 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
YARS2Tyrosine--tRNA ligase. (477 aa)
MARS2methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (593 aa)
TARS2threonine--tRNA ligase, mitochondrial. (594 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (3100 aa)
RNF220E3 ubiquitin-protein ligase RNF220 isoform X1. (566 aa)
GLULGlutamine synthetase. (413 aa)
PIAS3E3 SUMO-protein ligase PIAS3. (628 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
LIG4DNA ligase. (911 aa)
TTLL10LOW QUALITY PROTEIN: tubulin tyrosine ligase-like family, member 10. (798 aa)
LOC102748344asparagine--tRNA ligase, cytoplasmic-like. (348 aa)
LOC102732165threonine--tRNA ligase, mitochondrial-like. (129 aa)
MARSmethionine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa)
QARSglutamine--tRNA ligase isoform X2; Belongs to the class-I aminoacyl-tRNA synthetase family. (775 aa)
RNF6E3 ubiquitin-protein ligase RNF6 isoform X1. (683 aa)
ACSBG2long-chain-fatty-acid--CoA ligase ACSBG2-like. (653 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (653 aa)
LOC102737445E3 ubiquitin/ISG15 ligase TRIM25-like. (275 aa)
LOC102748619aspartate--tRNA ligase, cytoplasmic-like isoform X1. (501 aa)
AARS2alanine--tRNA ligase, mitochondrial-like; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (882 aa)
NARS2Probable asparagine--tRNA ligase, mitochondrial. (438 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32-like isoform X1. (655 aa)
PET112Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (557 aa)
LOC102730690Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (384 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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