(35 nodes) G-protein mediated events network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	LOC102734249	Serine/threonine-protein kinase DCLK1-like. (296 aa)
	CAMK4	Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
	LOC102734642	Guanine nucleotide-binding protein G(Olf) subunit alpha-like. (209 aa)
	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (578 aa)
	PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit. (145 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	LOC102730715	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
	LOC102734033	Guanine nucleotide-binding protein G(T) subunit alpha-3-like. (163 aa)
	GNAL	Guanine nucleotide-binding protein G(Olf) subunit alpha. (174 aa)
	CAMKK1	Calcium/calmodulin-dependent protein kinase kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	LOC102733606	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
	CALM3	Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
	GNA15	Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
	GNA11	Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
	THAP7	THAP domain-containing protein 7. (313 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	ADRBK1	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	LOC102735500	Cyclic nucleotide-binding domain-containing protein 2-like. (147 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit. (391 aa)
	LOC102726697	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
	LOC102738071	Calmodulin-like; Belongs to the calmodulin family. (113 aa)
	PRKAR2B	cAMP-dependent protein kinase type II-beta regulatory subunit. (417 aa)
	GNA14	Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	LRBA	Lipopolysaccharide-responsive and beige-like anchor protein. (1862 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	CALM3	A0A2U3XDB9	A0A2U3YN48	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.826
ADCY6	CAMK4	A0A2U3XDB9	A0A2U3Z2E8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type IV.	0.884
ADCY6	GNAI2	A0A2U3XDB9	A0A2U3Y188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.826
ADCY6	GNAL	A0A2U3XDB9	A0A2U3YZE7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(Olf) subunit alpha.	0.842
ADCY6	LOC102726697	A0A2U3XDB9	A0A2U3XNG2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.826
ADCY6	LOC102731038	A0A2U3XDB9	A0A2U3Z797	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.842
ADCY6	LOC102734033	A0A2U3XDB9	A0A2U3YZT3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(T) subunit alpha-3-like.	0.593
ADCY6	LOC102734642	A0A2U3XDB9	A0A2U3Z237	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(Olf) subunit alpha-like.	0.842
ADCY6	LOC102738071	A0A2U3XDB9	A0A2U3XLG6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like; Belongs to the calmodulin family.	0.826
ADCY6	LOC102746012	A0A2U3XDB9	A0A2U3YPK1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.895
ADCY6	PDE1B	A0A2U3XDB9	A0A2U3XBC0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.967
ADCY6	PLCB3	A0A2U3XDB9	A0A2U3YRT9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.500
ADCY6	PRKACA	A0A2U3XDB9	A0A2U3Z6A9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.919
ADCY6	PRKACB	A0A2U3XDB9	A0A2U3XZU0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.928
ADCY6	PRKAR1A	A0A2U3XDB9	A0A2U3YDZ5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.513
ADCY6	PRKAR2A	A0A2U3XDB9	A0A2U3XNY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase type II-alpha regulatory subunit.	0.407
ADCY6	PRKX	A0A2U3XDB9	A0A2U3Y2H1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily.	0.447
ADCY6	PTRHD1	A0A2U3XDB9	A0A2U3YCC1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.797
ADCY6	THAP7	A0A2U3XDB9	A0A2U3YLU4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	THAP domain-containing protein 7.	0.443