(32 nodes) Formation of the Early Elongation Complex network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	KHDC3L	KHDC3-like protein. (235 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	POLR2G	DNA-directed RNA polymerase II subunit RPB7. (172 aa)
	POLR2B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	POLR2I	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	LOC102725801	Uroplakin-3b-like protein-like. (252 aa)
	LOC102726582	DNA-directed RNA polymerase II subunit RPB11-like isoform X1. (117 aa)
	LOC102743390	Transcription elongation factor SPT4-like. (59 aa)
	GTF2F2	General transcription factor IIF subunit 2. (239 aa)
	NELFE	Negative elongation factor E isoform X1. (382 aa)
	NELFA	Negative elongation factor A. (532 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1. (114 aa)
	LOC102745267	LOW QUALITY PROTEIN: uncharacterized protein C6orf15 homolog. (307 aa)
	CCNH	cyclin-H-like; Belongs to the cyclin family. (344 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (661 aa)
	GTF2H2	General transcription factor IIH subunit. (395 aa)
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	POLR2K	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
	GTF2H3	General transcription factor IIH subunit 3. (162 aa)
	POLR2E	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1. (210 aa)
	POLR2D	DNA-directed RNA polymerase II subunit RPB4. (142 aa)
	POLR2L	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	LOC102743422	Negative elongation factor D-like. (572 aa)
	NCBP2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
	SUPT5H	Transcription elongation factor SPT5. (1087 aa)
	GTF2H1	General transcription factor IIH subunit 1. (441 aa)
	ERCC3	TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
	POLR2F	DNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
	POLR2C	DNA-directed RNA polymerase II subunit RPB3. (98 aa)
	LOC102733739	DNA-directed RNA polymerase II subunit RPB3-like. (189 aa)
	LOC102737270	Negative elongation factor B-like. (199 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNH	ERCC2	A0A2U3X8Q5	A0A2U3Y4Q8	cyclin-H-like; Belongs to the cyclin family.	TFIIH basal transcription factor complex helicase XPD subunit.	0.992
CCNH	ERCC3	A0A2U3X8Q5	A0A2U3YTS7	cyclin-H-like; Belongs to the cyclin family.	TFIIH basal transcription factor complex helicase XPB subunit.	0.985
CCNH	GTF2F2	A0A2U3X8Q5	A0A2U3XXU2	cyclin-H-like; Belongs to the cyclin family.	General transcription factor IIF subunit 2.	0.883
CCNH	GTF2H1	A0A2U3X8Q5	A0A2U3YSU7	cyclin-H-like; Belongs to the cyclin family.	General transcription factor IIH subunit 1.	0.988
CCNH	GTF2H2	A0A2U3X8Q5	A0A2U3Y5C4	cyclin-H-like; Belongs to the cyclin family.	General transcription factor IIH subunit.	0.983
CCNH	GTF2H3	A0A2U3X8Q5	A0A2U3Y9S3	cyclin-H-like; Belongs to the cyclin family.	General transcription factor IIH subunit 3.	0.996
CCNH	GTF2H5	A0A2U3X8Q5	A0A2U3Y694	cyclin-H-like; Belongs to the cyclin family.	General transcription factor IIH subunit 5.	0.969
CCNH	KHDC3L	A0A2U3X8Q5	A0A2U3XB81	cyclin-H-like; Belongs to the cyclin family.	KHDC3-like protein.	0.626
CCNH	LOC102725801	A0A2U3X8Q5	A0A2U3XR89	cyclin-H-like; Belongs to the cyclin family.	Uroplakin-3b-like protein-like.	0.787
CCNH	LOC102726582	A0A2U3X8Q5	A0A2U3XRA2	cyclin-H-like; Belongs to the cyclin family.	DNA-directed RNA polymerase II subunit RPB11-like isoform X1.	0.863
CCNH	LOC102733739	A0A2U3X8Q5	A0A2U3Z209	cyclin-H-like; Belongs to the cyclin family.	DNA-directed RNA polymerase II subunit RPB3-like.	0.820
CCNH	LOC102737270	A0A2U3X8Q5	A0A2U3Z8R4	cyclin-H-like; Belongs to the cyclin family.	Negative elongation factor B-like.	0.537
CCNH	LOC102743390	A0A2U3X8Q5	A0A2U3XUH9	cyclin-H-like; Belongs to the cyclin family.	Transcription elongation factor SPT4-like.	0.633
CCNH	LOC102745267	A0A2U3X8Q5	A0A2U3Y498	cyclin-H-like; Belongs to the cyclin family.	LOW QUALITY PROTEIN: uncharacterized protein C6orf15 homolog.	0.626
CCNH	MNAT1	A0A2U3X8Q5	A0A2U3XF64	cyclin-H-like; Belongs to the cyclin family.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.999
CCNH	NCBP2	A0A2U3X8Q5	A0A2U3YGT0	cyclin-H-like; Belongs to the cyclin family.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.614
CCNH	NELFE	A0A2U3X8Q5	A0A2U3XXV3	cyclin-H-like; Belongs to the cyclin family.	Negative elongation factor E isoform X1.	0.571
CCNH	POLR2A	A0A2U3X8Q5	A0A2U3Y5R9	cyclin-H-like; Belongs to the cyclin family.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.964
CCNH	POLR2B	A0A2U3X8Q5	A0A2U3XHG9	cyclin-H-like; Belongs to the cyclin family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.927
CCNH	POLR2C	A0A2U3X8Q5	A0A2U3YY28	cyclin-H-like; Belongs to the cyclin family.	DNA-directed RNA polymerase II subunit RPB3.	0.820