(14 nodes) Metabolism of nitric oxide: NOS3 activation and regulation network (Leptonychotes weddellii)

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	LOC102737789	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1-like. (96 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	DDAH2	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. (285 aa)
	LYPLA1	Acyl-protein thioesterase 1 isoform X2. (172 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	CALM3	Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
	NOSIP	Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (301 aa)
	LOC102750414	Formin-2-like. (76 aa)
	LOC102740880	Nitric oxide synthase, endothelial-like. (619 aa)
	WASL	Neural Wiskott-Aldrich syndrome protein. (487 aa)
	SPR	Sepiapterin reductase. (267 aa)
	CYGB	Cytoglobin; Belongs to the globin family. (190 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LOC102738071	Calmodulin-like; Belongs to the calmodulin family. (113 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CALM3	A0A2U3Y3V3	A0A2U3YN48	Non-specific serine/threonine protein kinase.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.551
AKT1	LOC102738071	A0A2U3Y3V3	A0A2U3XLG6	Non-specific serine/threonine protein kinase.	Calmodulin-like; Belongs to the calmodulin family.	0.551
AKT1	LOC102740880	A0A2U3Y3V3	A0A2U3Z7M4	Non-specific serine/threonine protein kinase.	Nitric oxide synthase, endothelial-like.	0.873
AKT1	SPR	A0A2U3Y3V3	A0A2U3X9D0	Non-specific serine/threonine protein kinase.	Sepiapterin reductase.	0.539
CALM3	AKT1	A0A2U3YN48	A0A2U3Y3V3	Calmodulin isoform X1; Belongs to the calmodulin family.	Non-specific serine/threonine protein kinase.	0.551
CALM3	CAV1	A0A2U3YN48	A0A2U3XCN0	Calmodulin isoform X1; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.869
CALM3	LOC102740880	A0A2U3YN48	A0A2U3Z7M4	Calmodulin isoform X1; Belongs to the calmodulin family.	Nitric oxide synthase, endothelial-like.	0.934
CAV1	CALM3	A0A2U3XCN0	A0A2U3YN48	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.869
CAV1	LOC102738071	A0A2U3XCN0	A0A2U3XLG6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Calmodulin-like; Belongs to the calmodulin family.	0.842
CAV1	LOC102740880	A0A2U3XCN0	A0A2U3Z7M4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase, endothelial-like.	0.908
CAV1	WASL	A0A2U3XCN0	A0A2U3X8S1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Neural Wiskott-Aldrich syndrome protein.	0.967
LOC102738071	AKT1	A0A2U3XLG6	A0A2U3Y3V3	Calmodulin-like; Belongs to the calmodulin family.	Non-specific serine/threonine protein kinase.	0.551
LOC102738071	CAV1	A0A2U3XLG6	A0A2U3XCN0	Calmodulin-like; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.842
LOC102738071	LOC102740880	A0A2U3XLG6	A0A2U3Z7M4	Calmodulin-like; Belongs to the calmodulin family.	Nitric oxide synthase, endothelial-like.	0.934
LOC102740880	AKT1	A0A2U3Z7M4	A0A2U3Y3V3	Nitric oxide synthase, endothelial-like.	Non-specific serine/threonine protein kinase.	0.873
LOC102740880	CALM3	A0A2U3Z7M4	A0A2U3YN48	Nitric oxide synthase, endothelial-like.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.934
LOC102740880	CAV1	A0A2U3Z7M4	A0A2U3XCN0	Nitric oxide synthase, endothelial-like.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.908
LOC102740880	LOC102738071	A0A2U3Z7M4	A0A2U3XLG6	Nitric oxide synthase, endothelial-like.	Calmodulin-like; Belongs to the calmodulin family.	0.934
LOC102740880	NOSIP	A0A2U3Z7M4	A0A2U3Z0Q7	Nitric oxide synthase, endothelial-like.	Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family.	0.903
NOSIP	LOC102740880	A0A2U3Z0Q7	A0A2U3Z7M4	Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family.	Nitric oxide synthase, endothelial-like.	0.903